PMID- 29604974
OWN - NLM
STAT- MEDLINE
DCOM- 20180904
LR  - 20180904
IS  - 0072-9752 (Print)
IS  - 0072-9752 (Linking)
VI  - 152
DP  - 2018
TI  - CNS immune reconstitution inflammatory syndrome.
PG  - 167-176
LID - B978-0-444-63849-6.00013-X [pii]
LID - 10.1016/B978-0-444-63849-6.00013-X [doi]
AB  - Immune reconstitution inflammatory syndrome (IRIS) describes a syndrome of 
      aberrant reconstituted immunity, often in association with HIV infection, 
      beginning with a normalization of CD4+ T-cell counts resulting in a dysregulated 
      immune response against an infecting opportunistic pathogen and the host. In this 
      chapter, we discuss the unique nature of IRIS when present in the central nervous 
      system (CNS IRIS) and the changes experienced with each host pathogen and its 
      unique influence on the immune system. Consensus on the mechanism of action of 
      the immune system in IRIS pathology is less clear and multiple theories have been 
      proposed. Here we explore the early history of the term IRIS, proposed mechanisms 
      and animal models, as well as common CNS pathogens associated with IRIS, and 
      management strategies.
CI  - (c) 2018 Elsevier B.V. All rights reserved.
FAU - Bowen, Lauren
AU  - Bowen L
AD  - Section of Infections of the Nervous System, National Institute for Neurologic 
      Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.
FAU - Nath, Avindra
AU  - Nath A
AD  - Section of Infections of the Nervous System, National Institute for Neurologic 
      Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States. 
      Electronic address: avindra.nath@nih.gov.
FAU - Smith, Bryan
AU  - Smith B
AD  - Section of Infections of the Nervous System, National Institute for Neurologic 
      Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States.
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Handb Clin Neurol
JT  - Handbook of clinical neurology
JID - 0166161
SB  - IM
MH  - Animals
MH  - Antiretroviral Therapy, Highly Active/methods
MH  - HIV Infections/*diagnosis/*immunology/therapy
MH  - Humans
MH  - Immune Reconstitution Inflammatory Syndrome/*diagnosis/*immunology/therapy
MH  - Leukoencephalopathy, Progressive Multifocal/diagnosis/immunology/therapy
OTO - NOTNLM
OT  - CNS immune reconstitution inflammatory syndrome (CNS IRIS)
OT  - Cryptococcus neoformans
OT  - HIV encephalitis
OT  - Toxoplasma gondii
OT  - progressive multifocal leukoencephalopathy (PML)
EDAT- 2018/04/02 06:00
MHDA- 2018/09/05 06:00
CRDT- 2018/04/02 06:00
PHST- 2018/04/02 06:00 [entrez]
PHST- 2018/04/02 06:00 [pubmed]
PHST- 2018/09/05 06:00 [medline]
AID - B978-0-444-63849-6.00013-X [pii]
AID - 10.1016/B978-0-444-63849-6.00013-X [doi]
PST - ppublish
SO  - Handb Clin Neurol. 2018;152:167-176. doi: 10.1016/B978-0-444-63849-6.00013-X.