PMID- 29605646
OWN - NLM
STAT- MEDLINE
DCOM- 20180718
LR  - 20181202
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 157
DP  - 2018 Aug 15
TI  - Responses of Labeo rohita fingerlings to N-acetyl-p-aminophenol toxicity.
PG  - 73-80
LID - S0147-6513(18)30250-1 [pii]
LID - 10.1016/j.ecoenv.2018.03.058 [doi]
AB  - The short term (96 h) toxicity of N-acetyl-p-aminophenol (0.58 mg/L - Treatment I 
      and 0.29 mg/L - Treatment II) on certain health indicators (haematology, 
      biochemical, and enzymology) of an Indian major carp Labeo rohita was studied. 
      When compared to control, N-acetyl-p-aminophenol treated fish showed a 
      significant (P < 0.05) decrease in haemoglobin (Hb), haematocrit (Hct), and 
      erythrocyte (RBC) levels throughout the study period. Whereas, a significant 
      (P < 0.05) increase were noted in leucocyte (WBC) counts (except 48 h in 
      Treatment-I), mean corpuscular volume (MCV), and mean corpuscular haemoglobin 
      (MCH) values (except 24 h in Treatment-I). Mean corpuscular haemoglobin 
      concentration (MCHC) values were found to be decreased significantly (P < 0.05) 
      in fish exposed to 0.58 mg/L of N-acetyl-p-aminophenol, whereas in 0.29 mg/L 
      exposed fish the values were found to be increased significantly (P < 0.05) 
      (except 72 h). A significant (P < 0.05) increase in plasma glucose levels was 
      noticed in fish exposed to 0.58 mg/L of N-acetyl-p-aminophenol (except 96 h). 
      However, a biphasic trend in plasma glucose level was observed at 0.29 mg/L of 
      N-acetyl-p-aminophenol exposed fish. Protein levels were found to be increased in 
      both the treatments except at the end of 48 and 96 h in 0.58 and 0.29 mg/L, 
      respectively. In both the treatments fluctuations of enzyme (GOT, GPT, and LDH) 
      activities in gill and liver were also noted. However, these enzyme activities 
      found to be significantly (P < 0.05) decreased in kidney and plasma of fish. From 
      the result we conclude that the drug N-acetyl-p-aminophenol upon short term 
      exposure could pose a risk to fish and the alteration of these parameters can be 
      used to ecological risk assessment of pharmaceuticals in aquatic organisms.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Renuka, Sivashankar
AU  - Renuka S
AD  - Unit of Toxicology, Department of Zoology, School of Life Sciences, Bharathiar 
      University, Coimbatore 641046, TamilNadu, India.
FAU - Poopal, Rama Krishnan
AU  - Poopal RK
AD  - Ecotoxicology and Toxicogenomics Lab, Department of Environmental Biotechnology, 
      School of Environmental Sciences, Bharathidasan University, Tiruchirappalli 
      620024, TamilNadu, India. Electronic address: poopalramakrishanan@ymail.com.
FAU - Ramesh, Mathan
AU  - Ramesh M
AD  - Unit of Toxicology, Department of Zoology, School of Life Sciences, Bharathiar 
      University, Coimbatore 641046, TamilNadu, India. Electronic address: 
      mathanramesh@yahoo.com.
FAU - Clara-Bindu, Frederick
AU  - Clara-Bindu F
AD  - Unit of Toxicology, Department of Zoology, School of Life Sciences, Bharathiar 
      University, Coimbatore 641046, TamilNadu, India.
LA  - eng
PT  - Journal Article
DEP - 20180330
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Blood Glucose)
RN  - 0 (Fish Proteins)
RN  - 0 (Hemoglobins)
RN  - 362O9ITL9D (Acetaminophen)
SB  - IM
MH  - Acetaminophen/*toxicity
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Carps/blood/growth & development/*metabolism
MH  - Erythrocyte Count
MH  - Erythrocyte Indices
MH  - Fish Proteins/metabolism
MH  - Hematocrit
MH  - Hemoglobins/metabolism
MH  - Leukocyte Count
OTO - NOTNLM
OT  - Biochemical
OT  - Enzyme
OT  - Haematology
OT  - Labeo rohita
OT  - NSAIDs
OT  - Toxicity
EDAT- 2018/04/02 06:00
MHDA- 2018/07/19 06:00
CRDT- 2018/04/02 06:00
PHST- 2018/01/20 00:00 [received]
PHST- 2018/03/14 00:00 [revised]
PHST- 2018/03/23 00:00 [accepted]
PHST- 2018/04/02 06:00 [pubmed]
PHST- 2018/07/19 06:00 [medline]
PHST- 2018/04/02 06:00 [entrez]
AID - S0147-6513(18)30250-1 [pii]
AID - 10.1016/j.ecoenv.2018.03.058 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2018 Aug 15;157:73-80. doi: 10.1016/j.ecoenv.2018.03.058. 
      Epub 2018 Mar 30.