PMID- 29607201
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210315
IS  - 2072-1439 (Print)
IS  - 2077-6624 (Electronic)
IS  - 2072-1439 (Linking)
VI  - 10
IP  - 2
DP  - 2018 Feb
TI  - Clinical implication of MEN1 mutation in surgically resected thymic carcinoid 
      patients.
PG  - E125-E129
LID - 10.21037/jtd.2018.01.127 [doi]
AB  - Thymic carcinoid is a rare but very aggressive neuroendocrine tumour derived from 
      the neuroendocrine system. Here we report a male patient with thymic atypical 
      carcinoid. Though thymic carcinoid is relatively common, the gene sequencing 
      profile was performed and the gene sequencing result indicated germline multiple 
      endocrine neoplasia type 1 (MEN1) mutation and two somatic mutations on MEN1 gene 
      and no copy number variation or fusion events were detected. It is well-known 
      that the mutation of MEN1 is the typical manifestation of MEN1 syndrome, which is 
      an autosome dominant disease that includes varying combinations of more than 20 
      endocrine and non-endocrine tumors. In the English literature, 7 cases of 
      solitary thymic carcinoid harboring somatic variants in MEN1 are reported in the 
      absence of other organs involvement as MEN1 syndrome presents. We summarized the 
      clinical features and prognosis of this rare thymic tumor.
FAU - Li, Xiongfei
AU  - Li X
AD  - Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical 
      University General Hospital, Tianjin 300052, China.
FAU - Li, Mingbiao
AU  - Li M
AD  - Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical 
      University General Hospital, Tianjin 300052, China.
FAU - Shi, Tao
AU  - Shi T
AD  - Department of Pathology, Lung Cancer Institute, Tianjin Medical University 
      General Hospital, Tianjin 300052, China.
FAU - Liu, Renwang
AU  - Liu R
AD  - Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical 
      University General Hospital, Tianjin 300052, China.
FAU - Ren, Dian
AU  - Ren D
AD  - Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical 
      University General Hospital, Tianjin 300052, China.
FAU - Yang, Fan
AU  - Yang F
AD  - Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical 
      University General Hospital, Tianjin 300052, China.
FAU - Wei, Sen
AU  - Wei S
AD  - Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical 
      University General Hospital, Tianjin 300052, China.
FAU - Chen, Gang
AU  - Chen G
AD  - Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical 
      University General Hospital, Tianjin 300052, China.
FAU - Chen, Jun
AU  - Chen J
AD  - Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical 
      University General Hospital, Tianjin 300052, China.
AD  - Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Lung 
      Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, 
      China.
FAU - Xu, Song
AU  - Xu S
AD  - Department of Lung Cancer Surgery, Lung Cancer Institute, Tianjin Medical 
      University General Hospital, Tianjin 300052, China.
AD  - Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Lung 
      Cancer Institute, Tianjin Medical University General Hospital, Tianjin 300052, 
      China.
LA  - eng
PT  - Case Reports
PL  - China
TA  - J Thorac Dis
JT  - Journal of thoracic disease
JID - 101533916
EIN - J Thorac Dis. 2021 Feb;13(2):1300-1301. PMID: 33717601
PMC - PMC5864637
OTO - NOTNLM
OT  - Multiple endocrine neoplasia type 1 (MEN1)
OT  - next generation sequencing (NGS)
OT  - prognosis
OT  - thymic carcinoid
COIS- Conflicts of Interests: The authors have no conflicts of interest to declare.
EDAT- 2018/04/03 06:00
MHDA- 2018/04/03 06:01
PMCR- 2018/02/01
CRDT- 2018/04/03 06:00
PHST- 2018/04/03 06:00 [entrez]
PHST- 2018/04/03 06:00 [pubmed]
PHST- 2018/04/03 06:01 [medline]
PHST- 2018/02/01 00:00 [pmc-release]
AID - jtd-10-02-E125 [pii]
AID - 10.21037/jtd.2018.01.127 [doi]
PST - ppublish
SO  - J Thorac Dis. 2018 Feb;10(2):E125-E129. doi: 10.21037/jtd.2018.01.127.