PMID- 29607397
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220316
IS  - 2364-3722 (Print)
IS  - 2196-9736 (Electronic)
IS  - 2196-9736 (Linking)
VI  - 6
IP  - 4
DP  - 2018 Apr
TI  - Initial experience with a novel resection and plication (RAP) method for acid 
      reflux: a pilot study.
PG  - E443-E449
LID - 10.1055/s-0044-101453 [doi]
AB  - BACKGROUND AND STUDY AIMS:  Current endoscopic therapies for gastroesophageal 
      reflux disorder (GERD) are limited by technical complexity, and/or cost. We 
      sought to evaluate the success of a novel resection and plication (RAP) 
      anti-reflux procedure. PATIENTS AND METHODS:  RAP was performed on 10 patients 
      with GERD refractory to proton pump inhibitor (PPI) therapy. RAP consists of 
      semi-circumferential mucosectomy along with full-thickness plication of the lower 
      esophageal sphincter (LES) and cardia. We assessed the technical success and 
      safety as well as followed GERD-Health Related Quality of Life (GERD-HRQL) scores 
      and medication usage. RESULTS: All patients underwent RAP without adverse events 
      and were discharged on the same day. Only half of the patients required general 
      anesthesia. Follow-up ranged from 5 to 24 months (median 9 months) and all 
      patients had a significant improvement in their GERD-HRQL scores ( P  < 0.0001, 
      95 % CI 19.3 - 25.3). 8 of 10 eliminated their daily PPI dependence. CONCLUSIONS: 
       The RAP method has potential as an effective anti-reflux option. Its main 
      advantages include a short procedure time, simple approach using readily 
      available equipment, and possible avoidance of general anesthesia.
FAU - Benias, Petros C
AU  - Benias PC
AD  - Zucker School of Medicine at Hofstra/Northwell.
FAU - D'Souza, Lionel
AU  - D'Souza L
AD  - Mount Sinai Beth Israel, New York, New York.
FAU - Lan, Gloria
AU  - Lan G
AD  - Mount Sinai Beth Israel, New York, New York.
FAU - Gluckman, Craig
AU  - Gluckman C
AD  - Mount Sinai Beth Israel, New York, New York.
FAU - Inamdar, Sumant
AU  - Inamdar S
AD  - Zucker School of Medicine at Hofstra/Northwell.
FAU - Trindade, Arvind J
AU  - Trindade AJ
AD  - Zucker School of Medicine at Hofstra/Northwell.
FAU - Miller, Larry S
AU  - Miller LS
AD  - Zucker School of Medicine at Hofstra/Northwell.
FAU - Carr-Locke, David L
AU  - Carr-Locke DL
AD  - New York Presbyterian Cornell, New York, New York.
LA  - eng
PT  - Journal Article
DEP - 20180329
PL  - Germany
TA  - Endosc Int Open
JT  - Endoscopy international open
JID - 101639919
PMC - PMC5876037
COIS- Competing interests None
EDAT- 2018/04/03 06:00
MHDA- 2018/04/03 06:01
PMCR- 2018/04/01
CRDT- 2018/04/03 06:00
PHST- 2017/10/21 00:00 [received]
PHST- 2017/12/27 00:00 [accepted]
PHST- 2018/04/03 06:00 [entrez]
PHST- 2018/04/03 06:00 [pubmed]
PHST- 2018/04/03 06:01 [medline]
PHST- 2018/04/01 00:00 [pmc-release]
AID - 10.1055/s-0044-101453 [doi]
PST - ppublish
SO  - Endosc Int Open. 2018 Apr;6(4):E443-E449. doi: 10.1055/s-0044-101453. Epub 2018 
      Mar 29.