PMID- 29607694
OWN - NLM
STAT- Publisher
LR  - 20240227
IS  - 1477-0903 (Electronic)
IS  - 0960-3271 (Linking)
DP  - 2018 Jan 1
TI  - Taurine attenuates acrylamide-induced apoptosis via a PI3K/AKT-dependent manner.
PG  - 960327118765335
LID - 10.1177/0960327118765335 [doi]
AB  - As a potent neurotoxic agent, acrylamide (ACR) is formed in food processing at 
      higher temperature. Taurine (TAU), a nonessential amino acid, is used to cure 
      neurodegenerative disorders, followed by activation of the phosphatidylinositol 
      3-kinase/protein kinase B (PI3K/AKT) signaling pathway. In this article, we 
      certified that antiapoptotic efficacy of TAU in vivo and vitro. ACR-treated rats 
      received TAU by drinking water 2 weeks after ACR intoxication. The results showed 
      that in treated rats, TAU alleviated ACR-induced neuronal apoptosis, which was 
      associated with the activation of PI3K/AKT signaling pathway. TAU attenuated 
      apoptosis caused by ACR through observing terminal deoxynucleotidyl 
      transferase-mediated dUTP nick end labeling (TUNEL)-positive cells, measure of 
      protein expression of Bcl-2, Bax, and caspase 3 activity. TAU-induced 
      antiapoptotic effect is PI3K/AKT-dependent, which was proved in ACR-intoxicated 
      ventral spinal cord 4.1 cells in the presence of AKT inhibitor, MK-2206. 
      Therefore, our results demonstrated that TAU-attenuated ACR-induced apoptosis in 
      vivo through a PI3K/AKT-dependent manner provided new sights in the molecular 
      mechanism of TAU protection against ACR-induced neurotoxicity.
FAU - Sun, G
AU  - Sun G
AD  - 1 The First Affiliated Hospital of Dalian Medical University, Liaoning, China.
FAU - Wang, X
AU  - Wang X
AD  - 1 The First Affiliated Hospital of Dalian Medical University, Liaoning, China.
FAU - Li, T
AU  - Li T
AD  - 1 The First Affiliated Hospital of Dalian Medical University, Liaoning, China.
FAU - Qu, S
AU  - Qu S
AD  - 2 Institute of Cancer Stem Cell, Dalian Medical University, Dalian, Liaoning, 
      China.
FAU - Sun, J
AU  - Sun J
AD  - 1 The First Affiliated Hospital of Dalian Medical University, Liaoning, China.
LA  - eng
PT  - Journal Article
DEP - 20180101
PL  - England
TA  - Hum Exp Toxicol
JT  - Human & experimental toxicology
JID - 9004560
OTO - NOTNLM
OT  - PI3K/AKT-dependent manner
OT  - Taurine
OT  - acrylamide
OT  - apoptosis
EDAT- 2018/04/03 06:00
MHDA- 2018/04/03 06:00
CRDT- 2018/04/03 06:00
PHST- 2018/04/03 06:00 [entrez]
PHST- 2018/04/03 06:00 [pubmed]
PHST- 2018/04/03 06:00 [medline]
AID - 10.1177/0960327118765335 [doi]
PST - aheadofprint
SO  - Hum Exp Toxicol. 2018 Jan 1:960327118765335. doi: 10.1177/0960327118765335.