PMID- 29608020
OWN - NLM
STAT- MEDLINE
DCOM- 20190418
LR  - 20190418
IS  - 1097-0045 (Electronic)
IS  - 0270-4137 (Linking)
VI  - 78
IP  - 10
DP  - 2018 Jul
TI  - Prostatic stromal inflammation is associated with bladder outlet obstruction in 
      patients with benign prostatic hyperplasia.
PG  - 743-752
LID - 10.1002/pros.23518 [doi]
AB  - BACKGROUND: Benign prostatic hyperplasia (BPH) is a common urologic disease in 
      older men. Prostatic inflammation research has focused on the magnitude of 
      inflammation; its location has received little attention. We investigated whether 
      the anatomic location of prostatic inflammation is related to the severity of 
      lower urinary tract symptoms (LUTS), measured subjectively and objectively. 
      METHODS: We retrospectively analyzed hematoxylin+eosin-stained tissue specimens 
      from 179 BPH patients who underwent transurethral resection of the prostate 
      (TURP) or holmium laser enucleation of the prostate (HoLEP). Chronic prostatic 
      inflammation was assessed by the grade (lymphocyte density), extent (lymphocyte 
      distribution), and location of inflammation. Each inflammation-finding type was 
      evaluated in relation to these clinical parameters: age, prostate volume, 
      prostate-specific antigen (PSA) value, body mass index (BMI), the frequency of 
      acute urinary retention (AUR) episodes, the international prostatic symptom score 
      (IPSS), and urodynamic study results. RESULTS: The magnitude and extent of 
      inflammation were not associated with any clinical parameters. We classified the 
      BPH patients into stromal (n = 72) versus non-stromal (n = 105) groups based on 
      their inflammation's dominant location. The stromal group's prostatic volume was 
      significantly larger than the non-stromal group's (63.8 vs 53.8 mL; P = 0.032). 
      AUR episodes were more significantly frequent in the stromal group (36.1% vs 
      11.4%; P = 0.006). Between-group differences in storage parameters (ie, maximum 
      cystometric capacity) in the urodynamic study were not significantly different. 
      Voiding parameters differed significantly between the stromal and non-stromal 
      groups: maximum detrusor pressure (maxPdet) (116.8 vs 94.5 cmH(2) O, P = 0.014), 
      Pdet at the maximum flow rate (Qmax) (95.8 vs 75.4 cmH(2) O, P = 0.014), and the 
      bladder outlet obstruction index (BOOI) (78.5 vs 56.3, P = 0.014). The stromal 
      group's Qmax was significantly lower than the non-stromal group's (7.3 vs 
      9.8 mL/s, P = 0.004). CONCLUSIONS: The location of inflammation in the prostate 
      might be an important factor affecting the severity of LUTS, especially voiding 
      dysfunction.
CI  - (c) 2018 Wiley Periodicals, Inc.
FAU - Inamura, So
AU  - Inamura S
AUID- ORCID: 0000-0002-1261-5059
AD  - Department of Urology, Faculty of Medical Sciences, University of Fukui, Eiheiji, 
      Japan.
AD  - Department of Tumor Pathology, Faculty of Medical Sciences, University of Fukui, 
      Eiheiji, Japan.
FAU - Ito, Hideaki
AU  - Ito H
AD  - Department of Urology, Faculty of Medical Sciences, University of Fukui, Eiheiji, 
      Japan.
FAU - Shinagawa, Tomochika
AU  - Shinagawa T
AD  - Department of Urology, Faculty of Medical Sciences, University of Fukui, Eiheiji, 
      Japan.
AD  - Department of Tumor Pathology, Faculty of Medical Sciences, University of Fukui, 
      Eiheiji, Japan.
FAU - Tsutsumiuchi, Manami
AU  - Tsutsumiuchi M
AD  - Department of Urology, Faculty of Medical Sciences, University of Fukui, Eiheiji, 
      Japan.
AD  - Department of Tumor Pathology, Faculty of Medical Sciences, University of Fukui, 
      Eiheiji, Japan.
FAU - Taga, Minekatsu
AU  - Taga M
AD  - Department of Urology, Faculty of Medical Sciences, University of Fukui, Eiheiji, 
      Japan.
AD  - Department of Tumor Pathology, Faculty of Medical Sciences, University of Fukui, 
      Eiheiji, Japan.
FAU - Kobayashi, Motohiro
AU  - Kobayashi M
AUID- ORCID: 0000-0002-7607-0801
AD  - Department of Tumor Pathology, Faculty of Medical Sciences, University of Fukui, 
      Eiheiji, Japan.
FAU - Yokoyama, Osamu
AU  - Yokoyama O
AD  - Department of Urology, Faculty of Medical Sciences, University of Fukui, Eiheiji, 
      Japan.
LA  - eng
PT  - Journal Article
DEP - 20180402
PL  - United States
TA  - Prostate
JT  - The Prostate
JID - 8101368
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Humans
MH  - Inflammation/etiology/*pathology/physiopathology
MH  - Lower Urinary Tract Symptoms/etiology/*pathology/physiopathology
MH  - Male
MH  - Middle Aged
MH  - Prostate/*pathology/physiopathology
MH  - Prostatic Hyperplasia/complications/*pathology/physiopathology
MH  - Retrospective Studies
MH  - Urinary Bladder Neck Obstruction/etiology/*pathology/physiopathology
MH  - Urodynamics
OTO - NOTNLM
OT  - bladder outlet obstruction
OT  - international prostatic symptom score
OT  - pressure flow study
OT  - prostatic stromal inflammation
OT  - urodynamic study
EDAT- 2018/04/03 06:00
MHDA- 2019/04/19 06:00
CRDT- 2018/04/03 06:00
PHST- 2018/01/31 00:00 [received]
PHST- 2018/03/13 00:00 [accepted]
PHST- 2018/04/03 06:00 [pubmed]
PHST- 2019/04/19 06:00 [medline]
PHST- 2018/04/03 06:00 [entrez]
AID - 10.1002/pros.23518 [doi]
PST - ppublish
SO  - Prostate. 2018 Jul;78(10):743-752. doi: 10.1002/pros.23518. Epub 2018 Apr 2.