PMID- 29608677
OWN - NLM
STAT- MEDLINE
DCOM- 20200522
LR  - 20200522
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Print)
IS  - 1047-3211 (Linking)
VI  - 29
IP  - 4
DP  - 2019 Apr 1
TI  - Regional GABA Concentrations Modulate Inter-network Resting-state Functional 
      Connectivity.
PG  - 1607-1618
LID - 10.1093/cercor/bhy059 [doi]
AB  - Coordinated activity within and differential activity between large-scale 
      neuronal networks such as the default mode network (DMN) and the control network 
      (CN) is a critical feature of brain organization. The CN usually exhibits 
      activations in response to cognitive tasks while the DMN shows deactivations; in 
      addition, activity between the two networks is anti-correlated at rest. To 
      address this issue, we used functional MRI to measure whole-brain BOLD signal 
      during resting-state and task-evoked conditions, and MR spectroscopy (MRS) to 
      quantify GABA and glutamate concentrations, in nodes within the DMN and CN (MPFC 
      and DLPFC, respectively) in 19 healthy individuals at 3 Tesla. We found that GABA 
      concentrations in the MPFC were significantly associated with DMN deactivation 
      during a working memory task and with anti-correlation between DMN and CN at rest 
      and during task performance, while GABA concentrations in the DLPFC weakly 
      modulated DMN-CN anti-correlation in the opposite direction. Highlighting 
      specificity, glutamate played a less significant role related to brain activity. 
      These findings indicate that GABA in the MPFC is potentially involved in 
      orchestrating between-network brain activity at rest and during task performance.
CI  - (c) The Author(s) 2018. Published by Oxford University Press. All rights reserved. 
      For Permissions, please e-mail: journals.permissions@oup.com.
FAU - Chen, Xi
AU  - Chen X
AD  - McLean Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
AD  - Psychotic Disorders Division, McLean Hospital, Harvard Medical School, Belmont, 
      MA, USA.
FAU - Fan, Xiaoying
AU  - Fan X
AD  - Psychotic Disorders Division, McLean Hospital, Harvard Medical School, Belmont, 
      MA, USA.
FAU - Hu, Yuzheng
AU  - Hu Y
AD  - Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural 
      Research Programs, National Institute of Health, Baltimore, MD, USA.
FAU - Zuo, Chun
AU  - Zuo C
AD  - McLean Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
FAU - Whitfield-Gabrieli, Susan
AU  - Whitfield-Gabrieli S
AD  - McGovern Institute for Brain Research, Massachusetts Institute of Technology, 
      Cambridge, MA, USA.
FAU - Holt, Daphne
AU  - Holt D
AD  - Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, 
      Charlestown, MA, USA.
FAU - Gong, Qiyong
AU  - Gong Q
AD  - Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of 
      Sichuan University, Chengdu, China.
FAU - Yang, Yihong
AU  - Yang Y
AD  - Neuroimaging Research Branch, National Institute on Drug Abuse, Intramural 
      Research Programs, National Institute of Health, Baltimore, MD, USA.
FAU - Pizzagalli, Diego A
AU  - Pizzagalli DA
AD  - McLean Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
AD  - Center For Depression, Anxiety and Stress Research, McLean Hospital, Harvard 
      Medical School, Belmont, MA, USA.
FAU - Du, Fei
AU  - Du F
AD  - McLean Imaging Center, McLean Hospital, Harvard Medical School, Belmont, MA, USA.
AD  - Psychotic Disorders Division, McLean Hospital, Harvard Medical School, Belmont, 
      MA, USA.
FAU - Ongur, Dost
AU  - Ongur D
AD  - Psychotic Disorders Division, McLean Hospital, Harvard Medical School, Belmont, 
      MA, USA.
LA  - eng
GR  - K24 MH104449/MH/NIMH NIH HHS/United States
GR  - R01 MH094594/MH/NIMH NIH HHS/United States
GR  - R21 MH114020/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, N.I.H., Intramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 56-12-2 (gamma-Aminobutyric Acid)
SB  - IM
MH  - Adult
MH  - Brain/metabolism/*physiology
MH  - Brain Mapping
MH  - Female
MH  - Glutamic Acid/metabolism/physiology
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Magnetic Resonance Spectroscopy
MH  - Male
MH  - Memory, Short-Term/physiology
MH  - Neural Pathways/metabolism/*physiology
MH  - Young Adult
MH  - gamma-Aminobutyric Acid/metabolism/*physiology
PMC - PMC6418388
OTO - NOTNLM
OT  - GABA
OT  - anti-correlation
OT  - default mode network
OT  - fMRI
OT  - glutamate
EDAT- 2018/04/03 06:00
MHDA- 2020/05/23 06:00
PMCR- 2020/04/01
CRDT- 2018/04/03 06:00
PHST- 2017/09/07 00:00 [received]
PHST- 2018/01/30 00:00 [revised]
PHST- 2018/04/03 06:00 [pubmed]
PHST- 2020/05/23 06:00 [medline]
PHST- 2018/04/03 06:00 [entrez]
PHST- 2020/04/01 00:00 [pmc-release]
AID - 4955774 [pii]
AID - bhy059 [pii]
AID - 10.1093/cercor/bhy059 [doi]
PST - ppublish
SO  - Cereb Cortex. 2019 Apr 1;29(4):1607-1618. doi: 10.1093/cercor/bhy059.