PMID- 29608979
OWN - NLM
STAT- MEDLINE
DCOM- 20180724
LR  - 20181202
IS  - 1872-8227 (Electronic)
IS  - 0168-8227 (Linking)
VI  - 140
DP  - 2018 Jun
TI  - A population-based study of epilepsy incidence in association with type 2 
      diabetes and severe hypoglycaemia.
PG  - 97-106
LID - S0168-8227(17)32033-8 [pii]
LID - 10.1016/j.diabres.2018.03.020 [doi]
AB  - AIMS: This study was conducted to investigate potential link between type 2 
      diabetes mellitus (T2DM) and epilepsy, and the role of severe hypoglycaemia (SH) 
      might play in the relationship. METHODS: This was a cohort study based on 
      Taiwan's National Health insurance claims. Totally 751,792 people with T2DM and 
      824,253 matched controls were identified in 2002-2003 and followed to incidence 
      of epilepsy or end of 2011. We used Cox proportional hazard model to relate 
      epilepsy incidence to separate and joint effects of T2DM and SH. A possible 
      mediation effect of SH on the association between T2DM and epilepsy was analyzed. 
      RESULTS: Over a 10-year follow-up, patients with T2DM had a higher incidence rate 
      of epilepsy than controls (35.0 vs 21.9 per 10,000 person-years). After 
      controlling for potential confounders including SH, T2DM increased the hazard of 
      epilepsy by some 50%. The stratified analysis further indicated that T2DM (hazard 
      ratio (HR)=1.44, 95% confidence interval (CI) = 1.40-1.47), and SH (HR = 2.22, 
      95% CI = 1.76-2.81) were both independent risk factors for epilepsy. SH did not 
      modify but mediated 12% of the association between T2DM and epilepsy. CONCLUSION: 
      Our findings supported that SH may increase the risk of epilepsy, and that T2DM 
      may increase risk of epilepsy independent of SH.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Lu, Chin-Li
AU  - Lu CL
AD  - Graduate Institute of Food Safety, College of Agriculture and Natural Resources, 
      National Chung Hsing University, Taichung, Taiwan.
FAU - Chang, Ya-Hui
AU  - Chang YH
AD  - Department of Public Health, College of Medicine, National Cheng Kung University, 
      Tainan, Taiwan.
FAU - Sun, Yu
AU  - Sun Y
AD  - Department of Neurology, En Chu Kong Hospital, Sanxia District, New Taipei City, 
      Taiwan.
FAU - Li, Chung-Yi
AU  - Li CY
AD  - Department of Public Health, College of Medicine, National Cheng Kung University, 
      Tainan, Taiwan; Department of Public Health, College of Public Health, China 
      Medical University, Taichung, Taiwan. Electronic address: 
      cyli99@mail.ncku.edu.tw.
LA  - eng
PT  - Journal Article
DEP - 20180331
PL  - Ireland
TA  - Diabetes Res Clin Pract
JT  - Diabetes research and clinical practice
JID - 8508335
SB  - IM
MH  - Aged
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Epilepsy/*etiology/pathology
MH  - Female
MH  - Humans
MH  - Hypoglycemia/*epidemiology
MH  - Incidence
MH  - Male
MH  - Middle Aged
MH  - Research Design
MH  - Risk Factors
OTO - NOTNLM
OT  - Cohort study
OT  - Epilepsy
OT  - Population-based study
OT  - Severe hypoglycaemia
OT  - Type 2 diabetes
EDAT- 2018/04/03 06:00
MHDA- 2018/07/25 06:00
CRDT- 2018/04/03 06:00
PHST- 2017/12/27 00:00 [received]
PHST- 2018/02/27 00:00 [revised]
PHST- 2018/03/15 00:00 [accepted]
PHST- 2018/04/03 06:00 [pubmed]
PHST- 2018/07/25 06:00 [medline]
PHST- 2018/04/03 06:00 [entrez]
AID - S0168-8227(17)32033-8 [pii]
AID - 10.1016/j.diabres.2018.03.020 [doi]
PST - ppublish
SO  - Diabetes Res Clin Pract. 2018 Jun;140:97-106. doi: 10.1016/j.diabres.2018.03.020. 
      Epub 2018 Mar 31.