PMID- 29609220
OWN - NLM
STAT- MEDLINE
DCOM- 20190722
LR  - 20200306
IS  - 2151-4658 (Electronic)
IS  - 2151-464X (Print)
IS  - 2151-464X (Linking)
VI  - 70
IP  - 12
DP  - 2018 Dec
TI  - Burden of Psoriatic Arthritis According to Different Definitions of Disease 
      Activity: Comparing Minimal Disease Activity and the Disease Activity Index for 
      Psoriatic Arthritis.
PG  - 1764-1770
LID - 10.1002/acr.23571 [doi]
AB  - OBJECTIVE: Treat-to-target strategies have improved outcomes in rheumatic 
      diseases. In psoriatic arthritis (PsA), the proposed targets are the 
      multidimensional target minimal disease activity (MDA) and the articular target 
      Disease Activity index for PsA (DAPSA). The aim of this study was to compare the 
      disease burden of PsA in patients with low disease activity according to the 2 
      definitions, MDA and DAPSA low disease activity (DAPSA-LDA), 1 year after 
      diagnosis. METHODS: We obtained data on MDA, DAPSA-LDA and disease burden 1 year 
      after diagnosis for patients included in the Dutch southwest early PsA cohort. 
      Disease burden was assessed in 2 domains: "Body functions," including the Short 
      Form 36 bodily pain (SF-36 BP) measure, and "Activity," including the Health 
      Assessment Questionnaire (HAQ). RESULTS: Among the 292 patients included, 48% 
      achieved MDA and 74% achieved DAPSA-LDA. Average scores for Body functions and 
      Activity were better in patients who achieved MDA and those who achieved 
      DAPSA-LDA. The scores were significantly better in the 46% of patients who 
      achieved both MDA and DAPSA-LDA than in the 29% of patients who achieved only 
      DAPSA-LDA. The average SF-36 BP score was higher in patients achieving both 
      targets (73.8; 95% confidence interval [95% CI] 71.1-76.5) than in patients 
      achieving only DAPSA-LDA (57.6; 95% CI 54.5-60.8). Similarly, mean HAQ scores 
      measuring Activity were 0.21 (95% CI 0.15-0.26) and 0.63 (95% CI 0.53-0.72), 
      respectively. CONCLUSION: Among patients with newly diagnosed PsA, 48% achieved 
      MDA and 74% achieved DAPSA-LDA after 1 year of receiving usual care. The average 
      disease burden was better in patients who achieved MDA and those who achieved 
      DAPSA-LDA. Also, patients who achieved only DAPSA-LDA reported worse outcomes 
      than those who also achieved MDA.
CI  - (c) 2018 The Authors. Arthritis Care & Research published by Wiley Periodicals, 
      Inc. on behalf of American College of Rheumatology.
FAU - Wervers, Kim
AU  - Wervers K
AD  - Erasmus Medical Center, Rotterdam, The Netherlands.
FAU - Vis, Marijn
AU  - Vis M
AD  - Erasmus Medical Center, Rotterdam, The Netherlands.
FAU - Tchetveriko, Ilja
AU  - Tchetveriko I
AD  - Albert Schweitzer Hospital, Dordrecht, The Netherlands.
FAU - Gerards, Andreas H
AU  - Gerards AH
AD  - Vlietland Hospital, Schiedam, The Netherlands.
FAU - Kok, Marc R
AU  - Kok MR
AD  - Maasstad Hospital, Rotterdam, The Netherlands.
FAU - Appels, Cathelijne W Y
AU  - Appels CWY
AD  - Amphia Hospital, Breda, The Netherlands.
FAU - van der Graaff, Wiebo L
AU  - van der Graaff WL
AD  - Rivas Hospital, Gorinchem, The Netherlands.
FAU - van Groenendael, Johannes H L M
AU  - van Groenendael JHLM
AD  - Reumazorg Zuid West Nederland, Roosendaal, The Netherlands.
FAU - Korswagen, Lindy-Anne
AU  - Korswagen LA
AD  - Sint Franciscus Gasthuis, Rotterdam, The Netherlands, on behalf of Cicero.
FAU - Veris-van Dieren, Josien J
AU  - Veris-van Dieren JJ
AD  - Reumazorg Zuid West Nederland, Roosendaal, The Netherlands.
FAU - Hazes, Johanna M W
AU  - Hazes JMW
AD  - Erasmus Medical Center, Rotterdam, The Netherlands.
FAU - Luime, Jolanda J
AU  - Luime JJ
AD  - Erasmus Medical Center, Rotterdam, The Netherlands.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Arthritis Care Res (Hoboken)
JT  - Arthritis care & research
JID - 101518086
RN  - 0 (Antirheumatic Agents)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antirheumatic Agents/*therapeutic use
MH  - Arthritis, Psoriatic/*diagnosis/*drug therapy/physiopathology/psychology
MH  - Female
MH  - Health Status
MH  - *Health Status Indicators
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Pain Measurement
MH  - Predictive Value of Tests
MH  - Remission Induction
MH  - Self Report
MH  - Severity of Illness Index
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC6587485
EDAT- 2018/04/03 06:00
MHDA- 2019/07/23 06:00
PMCR- 2019/06/21
CRDT- 2018/04/03 06:00
PHST- 2017/12/13 00:00 [received]
PHST- 2018/03/27 00:00 [accepted]
PHST- 2018/04/03 06:00 [pubmed]
PHST- 2019/07/23 06:00 [medline]
PHST- 2018/04/03 06:00 [entrez]
PHST- 2019/06/21 00:00 [pmc-release]
AID - ACR23571 [pii]
AID - 10.1002/acr.23571 [doi]
PST - ppublish
SO  - Arthritis Care Res (Hoboken). 2018 Dec;70(12):1764-1770. doi: 10.1002/acr.23571.