PMID- 29610581 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220408 IS - 1758-5996 (Print) IS - 1758-5996 (Electronic) IS - 1758-5996 (Linking) VI - 10 DP - 2018 TI - Bridging glycated hemoglobin with quality of life and health state; a randomized case-control study among type 2 diabetes patients. PG - 23 LID - 10.1186/s13098-018-0325-6 [doi] LID - 23 AB - BACKGROUND: The aim of this study was to explore the predictors of QOL and health state and examine the relationship with glycemic control among type 2 diabetes mellitus (T2DM) patients. METHODS: A randomized cross-sectional case-control study was conducted among n = 600 T2DM patients of Malaysia. Study population was distributed into three groups as: controls: patients with HbA1c /= 8 consecutively last 3 times. RESULTS: Participants with diabetes history > 10 years exhibits higher mean QOL score among all the three groups. In contrast mean health status score significantly (p < 0.001) reduced with the exposure duration of diabetes both within and intergroup assessment that participants with poor glycemic control (arm 2) had significantly higher mean QOL score with knowledge and self-care dimensions as compared to others, however mean health state scores were significantly (p < 0.001) lower in all assessment dimensions as compared to controls. The F test of significance showed that demographic and clinical parameters were strong predictors of QOL, whereas self-care activities, comorbidities, ability of positive management and BMI were significant predictors to health state for consistent glycemic control (controls) as compared to poor glycemic control (arm 2) participants. CONCLUSION: This study suggested that poor glycemic index reported low self-care behavior, increase barriers to daily living activities and poor ability to manage diabetes positively, which cause poor QOL and decrease health state. FAU - Gillani, Syed Wasif AU - Gillani SW AD - 1Department of Clinical & Hospital Pharmacy, College of Pharmacy, Taibah University, PO Box: 41411, Al-Madinah Al Munawarrah, Saudi Arabia. ISNI: 0000 0004 1754 9358. GRID: grid.412892.4 FAU - Ansari, Irfan Altaf AU - Ansari IA AD - 2Department of Pathology, College of Medicine, Taibah University, Al-Madinah Al Munawarrah, Kingdom of Saudi Arabia. ISNI: 0000 0004 1754 9358. GRID: grid.412892.4 FAU - Zaghloul, Hisham A AU - Zaghloul HA AD - 1Department of Clinical & Hospital Pharmacy, College of Pharmacy, Taibah University, PO Box: 41411, Al-Madinah Al Munawarrah, Saudi Arabia. ISNI: 0000 0004 1754 9358. GRID: grid.412892.4 FAU - Abdul, Mohi Iqbal Mohammad AU - Abdul MIM AD - 1Department of Clinical & Hospital Pharmacy, College of Pharmacy, Taibah University, PO Box: 41411, Al-Madinah Al Munawarrah, Saudi Arabia. ISNI: 0000 0004 1754 9358. GRID: grid.412892.4 FAU - Sulaiman, Syed Azhar Syed AU - Sulaiman SAS AD - 3School of Pharmaceutical Sciences, Universiti Sains Malaysia (USM), Penang, Malaysia. ISNI: 0000 0001 2294 3534. GRID: grid.11875.3a FAU - Baig, Mirza R AU - Baig MR AD - 4Dubai Pharmacy College, Dubai, UAE. ISNI: 0000 0004 1763 1394. GRID: grid.418592.3 LA - eng PT - Journal Article DEP - 20180327 PL - England TA - Diabetol Metab Syndr JT - Diabetology & metabolic syndrome JID - 101488958 PMC - PMC5872577 OTO - NOTNLM OT - Case-control study OT - HRQOL OT - HbA1c OT - Type 2 diabetes mellitus EDAT- 2018/04/04 06:00 MHDA- 2018/04/04 06:01 PMCR- 2018/03/27 CRDT- 2018/04/04 06:00 PHST- 2018/01/09 00:00 [received] PHST- 2018/03/17 00:00 [accepted] PHST- 2018/04/04 06:00 [entrez] PHST- 2018/04/04 06:00 [pubmed] PHST- 2018/04/04 06:01 [medline] PHST- 2018/03/27 00:00 [pmc-release] AID - 325 [pii] AID - 10.1186/s13098-018-0325-6 [doi] PST - epublish SO - Diabetol Metab Syndr. 2018 Mar 27;10:23. doi: 10.1186/s13098-018-0325-6. eCollection 2018.