PMID- 29610974
OWN - NLM
STAT- MEDLINE
DCOM- 20180615
LR  - 20181202
IS  - 1573-2959 (Electronic)
IS  - 0167-6369 (Linking)
VI  - 190
IP  - 5
DP  - 2018 Apr 2
TI  - The role of pollutants in type 2 diabetes mellitus (T2DM) and their prospective 
      impact on phytomedicinal treatment strategies.
PG  - 262
LID - 10.1007/s10661-018-6634-2 [doi]
AB  - Type 2 diabetes mellitus (T2DM) is the most common form of diabetes and it is 
      characterized by high blood sugar and abnormal sera lipid levels. Although the 
      specific reasons for the development of these abnormalities are still not well 
      understood, traditionally, genetic and lifestyle behavior have been reported as 
      the leading causes of this disease. In the last three decades, the number of 
      diabetic patients has drastically increased worldwide, with current statistics 
      suggesting the number is to double in the next two decades. To combat this 
      incurable ailment, orthodox medicines, to which economically disadvantaged 
      patients have minimal access to, have been used. Thus, a considerable 
      amalgamation of medicinal plants has recently been proven to possess therapeutic 
      capabilities to manage T2DM, and this has prompted studies primarily focusing on 
      the healing aspect of these plants, and ultimately, their commercialization. 
      Hence, this review aims to highlight the potential threat of pollutants, i.e., 
      polyfluoroalkyl compounds (PFCs), endocrine disrupting chemicals (EDCs) and heavy 
      metals, to medicinal plants, and their prospective impact on the phytomedicinal 
      therapy strategies for T2DM. It is further suggested that auxiliary research be 
      undertaken to better comprehend the factors that influence the uptake of these 
      compounds by these plants. This should include a comprehensive risk assessment of 
      phytomedicinal products destined for the treatment of T2DM. Regulations that 
      control the use of PFC-precursors in certain developing countries are also long 
      overdue.
FAU - Mudumbi, John Baptist Nzukizi
AU  - Mudumbi JBN
AUID- ORCID: 0000-0002-2743-1324
AD  - Bioresource Engineering Research Group (BioERG), Department of Biotechnology, 
      Cape Peninsula University of Technology, PO Box 652, Cape Town, 8000, South 
      Africa. jbmudumbi@gmail.com.
FAU - Ntwampe, Seteno Karabo Obed
AU  - Ntwampe SKO
AD  - Bioresource Engineering Research Group (BioERG), Department of Biotechnology, 
      Cape Peninsula University of Technology, PO Box 652, Cape Town, 8000, South 
      Africa.
FAU - Mekuto, Lukhanyo
AU  - Mekuto L
AD  - Department of Chemical Engineering, University of Johannesburg, PO Box 17011, 
      Johannesburg, Gauteng, 2028, South Africa.
FAU - Matsha, Tandi
AU  - Matsha T
AD  - Department of Bio-Medical sciences, Faculty of Health and Wellness Science, Cape 
      Peninsula University of Technology, PO Box 1906, Bellville, 7535, South Africa.
FAU - Itoba-Tombo, Elie Fereche
AU  - Itoba-Tombo EF
AD  - Bioresource Engineering Research Group (BioERG), Department of Biotechnology, 
      Cape Peninsula University of Technology, PO Box 652, Cape Town, 8000, South 
      Africa.
LA  - eng
GR  - 83436/National Research Foundation/
GR  - MRC-RFA-UFSP-01-2013/ VMH Study/South African Medical Research Council/
PT  - Journal Article
DEP - 20180402
PL  - Netherlands
TA  - Environ Monit Assess
JT  - Environmental monitoring and assessment
JID - 8508350
RN  - 0 (Endocrine Disruptors)
SB  - IM
MH  - Developing Countries/statistics & numerical data
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Endocrine Disruptors/toxicity
MH  - Environmental Exposure/*statistics & numerical data
MH  - Environmental Monitoring
MH  - Environmental Pollution/*statistics & numerical data
MH  - Humans
MH  - Prospective Studies
OTO - NOTNLM
OT  - Diabetes mellitus
OT  - EDCs
OT  - Medicinal plants
OT  - PFCs
OT  - Synergy
EDAT- 2018/04/04 06:00
MHDA- 2018/06/16 06:00
CRDT- 2018/04/04 06:00
PHST- 2017/07/26 00:00 [received]
PHST- 2018/03/22 00:00 [accepted]
PHST- 2018/04/04 06:00 [entrez]
PHST- 2018/04/04 06:00 [pubmed]
PHST- 2018/06/16 06:00 [medline]
AID - 10.1007/s10661-018-6634-2 [pii]
AID - 10.1007/s10661-018-6634-2 [doi]
PST - epublish
SO  - Environ Monit Assess. 2018 Apr 2;190(5):262. doi: 10.1007/s10661-018-6634-2.