PMID- 29611066
OWN - NLM
STAT- MEDLINE
DCOM- 20180817
LR  - 20181202
IS  - 1435-604X (Electronic)
IS  - 0268-8921 (Linking)
VI  - 33
IP  - 6
DP  - 2018 Aug
TI  - Application of wavelet analysis to detect dysfunction in cerebral blood flow 
      autoregulation during experimental hyperhomocysteinaemia.
PG  - 1327-1333
LID - 10.1007/s10103-018-2485-x [doi]
AB  - The purpose of the present study was to investigate the use of laser Doppler 
      flowmetry (LDF) signals coupled with spectral wavelet analysis to detect 
      endothelial link dysfunction in the autoregulation of cerebral blood flow in the 
      setting of hyperhomocysteinaemia (HHcy). Fifty-one rats were assigned to three 
      groups (intact, control, and HHcy) according to the results of biochemical assays 
      of homocysteine level in blood plasma. LDF signals on the rat brain were recorded 
      by LAKK-02 device to measure the microcirculatory blood flow. The laser operating 
      wavelength and output power density were1064 nm and 0.051 W/mm(2), respectively. 
      A Morlet mother wavelet transform was applied to the measured 8-min LDF signals, 
      and periodic oscillations with five frequency intervals were identified 
      (0.01-0.04 Hz, 0.04-0.15 Hz, 0.15-0.4 Hz, 0.4-2 Hz, and 2-5 Hz) corresponding to 
      endothelial, neurogenic, myogenic, respiratory, and cardiac origins, 
      respectively. In initial state, the amplitude of the oscillations decreased by 
      38% (P < 0.05) in the endothelial range in HHcy rats than in control rats. 
      Cerebral autoregulation was challenged by hemorrhagic hypotension. The lower 
      limit of autoregulation raised in a rat model of chronic HHcy (71.5 +/- 0.7 mmHg in 
      HHcy vs. 62.3 +/- 0.5 mmHg in control). The data obtained indicate that the laser 
      Doppler method and wavelet analysis may be successfully applied to detect the 
      dysfunction of the endothelial link in cerebral vessel tone and to reveal the 
      pathological shift of lower limit of autoregulation.
FAU - Aleksandrin, Valery V
AU  - Aleksandrin VV
AD  - Department of Molecular and Cell Pathophysiology, Federal State Budgetary 
      Scientific Institution "Institute of General Pathology and Pathophysiology", 
      Moscow, Russia. aleksandrin-54@mail.ru.
FAU - Ivanov, Alexander V
AU  - Ivanov AV
AD  - Department of Molecular and Cell Pathophysiology, Federal State Budgetary 
      Scientific Institution "Institute of General Pathology and Pathophysiology", 
      Moscow, Russia.
FAU - Virus, Edward D
AU  - Virus ED
AD  - Department of Molecular and Cell Pathophysiology, Federal State Budgetary 
      Scientific Institution "Institute of General Pathology and Pathophysiology", 
      Moscow, Russia.
FAU - Bulgakova, Polina O
AU  - Bulgakova PO
AD  - Department of Molecular and Cell Pathophysiology, Federal State Budgetary 
      Scientific Institution "Institute of General Pathology and Pathophysiology", 
      Moscow, Russia.
FAU - Kubatiev, Aslan A
AU  - Kubatiev AA
AD  - Department of Molecular and Cell Pathophysiology, Federal State Budgetary 
      Scientific Institution "Institute of General Pathology and Pathophysiology", 
      Moscow, Russia.
LA  - eng
GR  - 16-15-10340/Russian Science Foundation under Grant 16-15-10340/
PT  - Journal Article
DEP - 20180403
PL  - England
TA  - Lasers Med Sci
JT  - Lasers in medical science
JID - 8611515
SB  - IM
MH  - Animals
MH  - Brain/blood supply/physiology
MH  - Cerebrovascular Circulation/*physiology
MH  - Chronic Disease
MH  - Hemodynamics
MH  - Hemorrhage/physiopathology
MH  - *Homeostasis
MH  - Humans
MH  - Hyperhomocysteinemia/*physiopathology
MH  - Laser-Doppler Flowmetry
MH  - Male
MH  - Rats
MH  - Skin/blood supply
MH  - *Wavelet Analysis
OTO - NOTNLM
OT  - Cerebral blood flow
OT  - Hyperhomocysteinaemia
OT  - Laser Doppler flowmetry
OT  - Wavelet analysis
EDAT- 2018/04/04 06:00
MHDA- 2018/08/18 06:00
CRDT- 2018/04/04 06:00
PHST- 2017/11/02 00:00 [received]
PHST- 2018/03/13 00:00 [accepted]
PHST- 2018/04/04 06:00 [pubmed]
PHST- 2018/08/18 06:00 [medline]
PHST- 2018/04/04 06:00 [entrez]
AID - 10.1007/s10103-018-2485-x [pii]
AID - 10.1007/s10103-018-2485-x [doi]
PST - ppublish
SO  - Lasers Med Sci. 2018 Aug;33(6):1327-1333. doi: 10.1007/s10103-018-2485-x. Epub 
      2018 Apr 3.