PMID- 29611402
OWN - NLM
STAT- MEDLINE
DCOM- 20180601
LR  - 20181202
IS  - 1976-2437 (Electronic)
IS  - 0513-5796 (Print)
IS  - 0513-5796 (Linking)
VI  - 59
IP  - 3
DP  - 2018 May
TI  - Delta Neutrophil Index Is Associated with Vasculitis Activity and Risk of Relapse 
      in ANCA-Associated Vasculitis.
PG  - 397-405
LID - 10.3349/ymj.2018.59.3.397 [doi]
AB  - PURPOSE: Delta neutrophil index (DNI) represents the immature granulocytes count 
      associated with neutrophil-consumption. We investigated whether DNI might be 
      associated with Birmingham vasculitis activity score (BVAS) at diagnosis and 
      could predict relapse during the follow-up in patients with antineutrophil 
      cytoplasmic antibody-associated vasculitis (AAV). MATERIALS AND METHODS: We 
      reviewed the medical records of 97 patients having DNI results. Twenty patients 
      had granulomatosis with polyangiitis (GPA), 58 had microscopic polyangiitis 
      (MPA), and 19 had eosinophilic GPA (EGPA). We collected clinical and laboratory 
      data including BVAS, five factor score (FFS), and DNI. The correlation 
      coefficient and cumulative relapse free survival rate were obtained. The optimal 
      cut-off of DNI was extrapolated by calculating the area under the receiver 
      operator characteristic curve. RESULTS: DNI was significantly related to 
      cross-sectional BVAS. Furthermore, among continuous variables, only DNI could 
      reflect BVAS of GPA and MPA, but not EGPA. Severe AAV was defined as BVAS >/=20 
      (the highest quartile). At diagnosis, patients having DNI >/=0.65% had a 
      significantly higher risk of severe GPA and MPA than those having not (relative 
      risk 4.255) at diagnosis. During the follow-up, DNI >/=0.65% could predict the 
      higher relapse rate. CONCLUSION: DNI could reflect BVAS at diagnosis and 
      furthermore, DNI >/=0.65% could not only identify severe AAV at diagnosis, but also 
      predict relapse during the follow-up in patients with GPA and MPA.
CI  - (c) Copyright: Yonsei University College of Medicine 2018.
FAU - Yoo, Juyoung
AU  - Yoo J
AUID- ORCID: 0000-0001-8882-1695
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Ahn, Sung Soo
AU  - Ahn SS
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Jung, Seung Min
AU  - Jung SM
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Song, Jason Jungsik
AU  - Song JJ
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Korea.
FAU - Park, Yong Beom
AU  - Park YB
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Korea.
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul, Korea.
FAU - Lee, Sang Won
AU  - Lee SW
AUID- ORCID: 0000-0002-8038-3341
AD  - Division of Rheumatology, Department of Internal Medicine, Yonsei University 
      College of Medicine, Seoul, Korea.
AD  - Institute for Immunology and Immunological Diseases, Yonsei University College of 
      Medicine, Seoul, Korea. sangwonlee@yuhs.ac.
LA  - eng
PT  - Journal Article
PL  - Korea (South)
TA  - Yonsei Med J
JT  - Yonsei medical journal
JID - 0414003
RN  - 0 (Antibodies, Antineutrophil Cytoplasmic)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Anti-Neutrophil Cytoplasmic Antibody-Associated 
      Vasculitis/*diagnosis/epidemiology/immunology
MH  - Antibodies, Antineutrophil Cytoplasmic
MH  - Cross-Sectional Studies
MH  - Female
MH  - Granulomatosis with Polyangiitis/diagnosis/epidemiology/*immunology
MH  - Humans
MH  - Microscopic Polyangiitis/diagnosis/epidemiology/*immunology
MH  - Middle Aged
MH  - *Neutrophils
MH  - Predictive Value of Tests
MH  - Quality of Life
MH  - *Recurrence
MH  - Retrospective Studies
MH  - Risk
MH  - Severity of Illness Index
PMC - PMC5889992
OTO - NOTNLM
OT  - Delta neutrophil index
OT  - granulomatosis with polyangiitis
OT  - microscopic polyangiitis
OT  - vasculitis activity
COIS- The authors have no financial conflicts of interest.
EDAT- 2018/04/04 06:00
MHDA- 2018/06/02 06:00
PMCR- 2018/05/01
CRDT- 2018/04/04 06:00
PHST- 2017/11/27 00:00 [received]
PHST- 2017/12/26 00:00 [revised]
PHST- 2018/01/12 00:00 [accepted]
PHST- 2018/04/04 06:00 [entrez]
PHST- 2018/04/04 06:00 [pubmed]
PHST- 2018/06/02 06:00 [medline]
PHST- 2018/05/01 00:00 [pmc-release]
AID - 59.397 [pii]
AID - 10.3349/ymj.2018.59.3.397 [doi]
PST - ppublish
SO  - Yonsei Med J. 2018 May;59(3):397-405. doi: 10.3349/ymj.2018.59.3.397.