PMID- 29614845
OWN - NLM
STAT- MEDLINE
DCOM- 20190225
LR  - 20211204
IS  - 2072-6651 (Electronic)
IS  - 2072-6651 (Linking)
VI  - 10
IP  - 4
DP  - 2018 Apr 2
TI  - Bee Venom Phospholipase A2 Alleviate House Dust Mite-Induced Atopic 
      Dermatitis-Like Skin Lesions by the CD206 Mannose Receptor.
LID - 10.3390/toxins10040146 [doi]
LID - 146
AB  - Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by 
      highly pruritic, erythematous, and eczematous skin plaques. We previously 
      reported that phospholipase A2 (PLA2) derived from bee venom alleviates AD-like 
      skin lesions induced by 2,4-dinitrochlorobenzene (DNCB) and house dust mite 
      extract (Dermatophagoides farinae extract, DFE) in a murine model. However, the 
      underlying mechanisms of PLA2 action in actopic dermatitis remain unclear. In 
      this study, we showed that PLA2 treatment inhibited epidermal thickness, serum 
      immunoglobulin E (IgE) and cytokine levels, macrophage and mast cell infiltration 
      in the ear of an AD model induced by DFE and DNCB. In contrast, these effects 
      were abrogated in CD206 mannose receptor-deficient mice exposed to DFE and DNCB 
      in the ear. These data suggest that bvPLA2 alleviates atopic skin inflammation 
      via interaction with CD206.
FAU - Shin, Dasom
AU  - Shin D
AUID- ORCID: 0000-0002-8699-0169
AD  - Department of Science in Korean Medicine, College of Korean Medicine, Kyung Hee 
      University, 26 kyungheedae-ro, dongdaemoon-ku, Seoul 02447, Korea. 
      ssd060@naver.com.
FAU - Choi, Won
AU  - Choi W
AD  - Department of Science in Korean Medicine, College of Korean Medicine, Kyung Hee 
      University, 26 kyungheedae-ro, dongdaemoon-ku, Seoul 02447, Korea. 
      wonones@naver.com.
FAU - Bae, Hyunsu
AU  - Bae H
AUID- ORCID: 0000-0002-0299-3582
AD  - Department of Science in Korean Medicine, College of Korean Medicine, Kyung Hee 
      University, 26 kyungheedae-ro, dongdaemoon-ku, Seoul 02447, Korea. 
      hbae@khu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180402
PL  - Switzerland
TA  - Toxins (Basel)
JT  - Toxins
JID - 101530765
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Bee Venoms)
RN  - 0 (Cytokines)
RN  - 0 (Dinitrochlorobenzene)
RN  - 0 (Lectins, C-Type)
RN  - 0 (Mannose Receptor)
RN  - 0 (Mannose-Binding Lectins)
RN  - 0 (Receptors, Cell Surface)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - EC 3.1.1.4 (Phospholipases A2)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/pharmacology/*therapeutic use
MH  - Bee Venoms/*enzymology
MH  - Cytokines/blood
MH  - Dermatitis, Atopic/*drug therapy/metabolism
MH  - Dinitrochlorobenzene
MH  - Immunoglobulin E/blood
MH  - Lectins, C-Type/genetics/*metabolism
MH  - Male
MH  - Mannose Receptor
MH  - Mannose-Binding Lectins/genetics/*metabolism
MH  - Mice, Inbred C57BL
MH  - Mice, Knockout
MH  - Phospholipases A2/pharmacology/*therapeutic use
MH  - Pyroglyphidae
MH  - Receptors, Cell Surface/genetics/*metabolism
PMC - PMC5923312
OTO - NOTNLM
OT  - 2,4-dinitrochlorobenzene (DNCB)
OT  - CD206
OT  - atopic dermatitis (AD)
OT  - bee venom phospholipase A2 (bvPLA2)
OT  - house dust mite extract (DFE)
OT  - mannose receptor
OT  - skin inflammation
COIS- The authors declare no conflict of interest.
EDAT- 2018/04/05 06:00
MHDA- 2019/02/26 06:00
PMCR- 2018/04/01
CRDT- 2018/04/05 06:00
PHST- 2018/02/08 00:00 [received]
PHST- 2018/03/25 00:00 [revised]
PHST- 2018/03/31 00:00 [accepted]
PHST- 2018/04/05 06:00 [entrez]
PHST- 2018/04/05 06:00 [pubmed]
PHST- 2019/02/26 06:00 [medline]
PHST- 2018/04/01 00:00 [pmc-release]
AID - toxins10040146 [pii]
AID - toxins-10-00146 [pii]
AID - 10.3390/toxins10040146 [doi]
PST - epublish
SO  - Toxins (Basel). 2018 Apr 2;10(4):146. doi: 10.3390/toxins10040146.