PMID- 29614951
OWN - NLM
STAT- MEDLINE
DCOM- 20180917
LR  - 20181114
IS  - 1347-4715 (Electronic)
IS  - 1342-078X (Print)
IS  - 1342-078X (Linking)
VI  - 23
IP  - 1
DP  - 2018 Apr 3
TI  - Synergistic effects of brain-derived neurotrophic factor (BDNF) and exercise 
      intensity on memory in the adolescent brain: a commentary.
PG  - 12
LID - 10.1186/s12199-018-0701-8 [doi]
LID - 12
AB  - This commentary highlights the recently published study by Jeon and Ha (Environ 
      Health Prev Med 22:27, 2017) examining the effects of exercise intensity and 
      brain-derived neurotrophic factor (BDNF) on memory in adolescents. This 12-week 
      training study elicited increases in BDNF and improvements in working memory 
      during moderate- and high-intensity exercise, which may have been achieved 
      through improved brain tissue oxygenation, nutrient delivery, and BDNF mRNA 
      expression. These improvements highlight the positive neuroendocrinological 
      effects of BDNF and its role as a potential candidate molecule, as a mediator of 
      synaptic plasticity. In this commentary, we aim to highlight the strengths and 
      potential areas of consideration of Jeon and Ha (Environ Health Prev Med 22:27, 
      2017). We also offer insight into the clinical implications of this study, such 
      as advocating for exercise in healthy children and as adjunctive therapy in 
      pathological states. This study is promising and further highlights the 
      importance of cardiorespiratory exercise in improving physiological health and 
      cognitive functioning in youth through the phenomenon of neuroplasticity.
FAU - Tharmaratnam, Tharmegan
AU  - Tharmaratnam T
AUID- ORCID: 0000-0002-7867-2689
AD  - School of Medicine, Royal College of Surgeons in Ireland-Medical University of 
      Bahrain, Adliya, Bahrain. tharmegan.tharmaratnam@gmail.com.
FAU - Tabobondung, Tyler
AU  - Tabobondung T
AD  - Brantford General Hospital, Department of Family Medicine, Michael G. DeGroote 
      School of Medicine, McMaster University, Hamilton, ON, Canada.
FAU - Tabobondung, Taylor
AU  - Tabobondung T
AD  - Department of Physical and Environmental Sciences, University of Toronto, 
      Toronto, ON, Canada.
FAU - Doherty, Sally
AU  - Doherty S
AD  - School of Medicine, Royal College of Surgeons in Ireland-Medical University of 
      Bahrain, Adliya, Bahrain.
AD  - School of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland.
LA  - eng
PT  - Journal Article
DEP - 20180403
PL  - Japan
TA  - Environ Health Prev Med
JT  - Environmental health and preventive medicine
JID - 9609642
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 7171WSG8A2 (BDNF protein, human)
SB  - IM
MH  - Adolescent
MH  - Brain-Derived Neurotrophic Factor/*metabolism
MH  - Exercise/*physiology
MH  - Humans
MH  - Memory/*physiology
PMC - PMC5883591
OTO - NOTNLM
OT  - Adolescence
OT  - Aerobic exercise
OT  - Brain-derived neurotrophic factor
OT  - Cognition
OT  - Exercise intensity
OT  - Memory
OT  - Neurogenesis
COIS- ETHICS APPROVAL AND CONSENT TO PARTICIPATE: Not applicable CONSENT FOR 
      PUBLICATION: Not applicable COMPETING INTERESTS: The authors declare that they 
      have no competing interests. PUBLISHER'S NOTE: Springer Nature remains neutral 
      with regard to jurisdictional claims in published maps and institutional 
      affiliations.
EDAT- 2018/04/05 06:00
MHDA- 2018/09/18 06:00
PMCR- 2018/04/03
CRDT- 2018/04/05 06:00
PHST- 2018/02/09 00:00 [received]
PHST- 2018/03/20 00:00 [accepted]
PHST- 2018/04/05 06:00 [entrez]
PHST- 2018/04/05 06:00 [pubmed]
PHST- 2018/09/18 06:00 [medline]
PHST- 2018/04/03 00:00 [pmc-release]
AID - 10.1186/s12199-018-0701-8 [pii]
AID - 701 [pii]
AID - 10.1186/s12199-018-0701-8 [doi]
PST - epublish
SO  - Environ Health Prev Med. 2018 Apr 3;23(1):12. doi: 10.1186/s12199-018-0701-8.