PMID- 29615450
OWN - NLM
STAT- MEDLINE
DCOM- 20190211
LR  - 20190215
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 8
IP  - 4
DP  - 2018 Apr 3
TI  - Prospective, single UK centre, comparative study of the predictive values of 
      contrast-enhanced ultrasound compared to time-resolved CT angiography in the 
      detection and characterisation of endoleaks in high-risk patients undergoing 
      endovascular aneurysm repair surveillance: a protocol.
PG  - e020835
LID - 10.1136/bmjopen-2017-020835 [doi]
LID - e020835
AB  - INTRODUCTION: Diagnosis of endoleaks is imperative to prevent failure of 
      endovascular aneurysm repairs (EVARs). The gold standard for diagnosis of 
      endoleaks is catheter-directed subtraction angiography, which is not a 
      practicable choice for surveillance. CT angiography (CTA) is the historical 
      surveillance modality of choice. Concerns over cost, potential nephrotoxicity of 
      contrast agents and repeated radiation exposure led to colour duplex ultrasound 
      scan (CDUS) becoming an established alternative. CDUS has a lower sensitivity and 
      specificity for endoleaks detection compared to CTA. Contrast-enhanced ultrasound 
      scan (CEUS) represents an improvement of ultrasound imaging but comparisons 
      against CTA report widely varying results, likely due to technical factors of 
      CEUS and limitations of single-phase CTA.The development of time-resolved CTA 
      (tCTA) offers timing information that much more closely mirrors the dynamic 
      information available from CEUS. Theoretically, these two imaging modalities have 
      the best potential for diagnostic accuracy. The aim of this study will be to 
      compare CEUS to tCTA and investigate the utility of other measurements available 
      from tCTA. METHODS AND ANALYSIS: This is a prospective, single UK centre, 
      comparative study of paired binary diagnostic imaging modalities. Patients 
      identified in routine post-EVAR surveillance as at risk of having a graft-related 
      endoleak will undergo a CEUS and tCTA on the same day. This will allow the first 
      comparison of CEUS to a semidynamic form of CTA. CEUS sensitivity and specificity 
      to endoleak detection will be calculated. ETHICS AND DISSEMINATION: The study has 
      achieved ethical approval. We hope the results will define the diagnostic 
      accuracy of CEUS in comparison to a semidynamic form of CTA, representing a 
      methodological improvement from previous studies. Results will be submitted for 
      presentation at national and international vascular surgeryandradiology meetings. 
      The full results are planned to be published in a medical journal. TRIAL 
      REGISTRATION NUMBER: NCT02688751.
CI  - (c) Article author(s) (or their employer(s) unless otherwise stated in the text of 
      the article) 2018. All rights reserved. No commercial use is permitted unless 
      otherwise expressly granted.
FAU - Roy, Iain Nicholas
AU  - Roy IN
AUID- ORCID: 0000-0001-9701-8319
AD  - Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
AD  - Liverpool Vascular and Endovascular Service, Royal Liverpool University Hospital, 
      Liverpool, UK.
FAU - Chan, Tze Yuan
AU  - Chan TY
AD  - Department of Radiology, Royal Liverpool University Hospital, Liverpool, UK.
FAU - Czanner, Gabriela
AU  - Czanner G
AD  - Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
AD  - Department of Biostatistics, University of Liverpool, Liverpool, UK.
FAU - Wallace, Steve
AU  - Wallace S
AD  - Liverpool Vascular and Endovascular Service, Royal Liverpool University Hospital, 
      Liverpool, UK.
FAU - Vallabhaneni, Srinivasa Rao
AU  - Vallabhaneni SR
AD  - Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
AD  - Liverpool Vascular and Endovascular Service, Royal Liverpool University Hospital, 
      Liverpool, UK.
LA  - eng
SI  - ClinicalTrials.gov/NCT02688751
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180403
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
RN  - 0 (Contrast Media)
SB  - IM
MH  - Aortic Aneurysm, Abdominal
MH  - *Aortography
MH  - *Computed Tomography Angiography
MH  - Contrast Media
MH  - *Endoleak/diagnostic imaging
MH  - Endovascular Procedures
MH  - Humans
MH  - Predictive Value of Tests
MH  - Prospective Studies
MH  - Tomography, X-Ray Computed
PMC - PMC5892749
OTO - NOTNLM
OT  - aneurysm
OT  - diagnostic testing
OT  - imaging
OT  - ultrasound
COIS- Competing interests: None declared.
EDAT- 2018/04/05 06:00
MHDA- 2019/02/12 06:00
PMCR- 2018/04/03
CRDT- 2018/04/05 06:00
PHST- 2018/04/05 06:00 [entrez]
PHST- 2018/04/05 06:00 [pubmed]
PHST- 2019/02/12 06:00 [medline]
PHST- 2018/04/03 00:00 [pmc-release]
AID - bmjopen-2017-020835 [pii]
AID - 10.1136/bmjopen-2017-020835 [doi]
PST - epublish
SO  - BMJ Open. 2018 Apr 3;8(4):e020835. doi: 10.1136/bmjopen-2017-020835.