PMID- 29615545
OWN - NLM
STAT- MEDLINE
DCOM- 20190510
LR  - 20190510
IS  - 2149-2271 (Electronic)
IS  - 2149-2263 (Print)
IS  - 2149-2263 (Linking)
VI  - 19
IP  - 4
DP  - 2018 Apr
TI  - Pulmonary endarterectomy for patients with chronic thromboembolic disease.
PG  - 273-278
LID - 10.14744/AnatolJCardiol.2018.37929 [doi]
AB  - OBJECTIVE: Chronic thromboembolic disease (CTED) is characterized by persistent 
      pulmonary thromboembolic occlusions without pulmonary hypertension. Early 
      surgical treatment by performing pulmonary endarterectomy (PEA) may improve 
      symptoms. The goal of the study was to review our experience and early outcome of 
      PEA in patients with CTED. METHODS: Data were prospectively collected on all 
      patients who underwent PEA between 2011 and 2015. Patients with CTED and a mean 
      pulmonary artery pressure (mPAP) of <25 mm Hg were identified. All patients were 
      in New York Heart Association (NYHA) functional class II or III. Measured 
      outcomes were in-hospital complications, improvement in cardiac function and 
      exercise capacity, and survival after PEA. Patients were reassessed at 6 months 
      following surgery. RESULTS: A total of 23 patients underwent surgery. There was 
      no in-hospital mortality, but complications occurred in six patients (26%). At 6 
      months following surgery, 93% of the patients remained alive. Following PEA, the 
      mPAP fell significantly from 21.0+/-2.7 mm Hg to 18.2+/-5.5 mm Hg (p<.001). Pulmonary 
      vascular resistance also significantly decreased from 2.2+/-0.7 wood to 1.5+/-0.5 
      wood (p<.001). The 6-min walking distance significantly increased from 322.6+/-80.4 
      m to 379.9+/-68.2 m (p<.001). There was a significant symptomatic improvement in 
      all survivors in NYHA functional classes I or II at 6 months following surgery 
      (p=.001). CONCLUSION: PEA in selected patients with CTED resulted in significant 
      improvement in symptoms. The selection of patients for undergoing PEA in the 
      absence of pulmonary hypertension must be made based on patients' expectations 
      and their acceptance of the perioperative risk.
FAU - Olgun Yildizeli, Sehnaz
AU  - Olgun Yildizeli S
FAU - Kepez, Alper
AU  - Kepez A
FAU - Tas, Serpil
AU  - Tas S
FAU - Yanartas, Mehmed
AU  - Yanartas M
FAU - Durusoy, Ali Fuad
AU  - Durusoy AF
FAU - Erkilinc, Atakan
AU  - Erkilinc A
FAU - Mutlu, Bulent
AU  - Mutlu B
FAU - Kaymaz, Cihangir
AU  - Kaymaz C
FAU - Sunar, Hasan
AU  - Sunar H
FAU - Yildizeli, Bedrettin
AU  - Yildizeli B
AD  - Department of Thoracic Surgery, Faculty of Medicine, Marmara University; 
      Istanbul-Turkey.
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Anatol J Cardiol
JT  - Anatolian journal of cardiology
JID - 101652981
SB  - IM
MH  - Adult
MH  - Aged
MH  - Chronic Disease
MH  - Endarterectomy
MH  - Female
MH  - Humans
MH  - *Hypertension, Pulmonary
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Pulmonary Embolism/*surgery
MH  - Thromboembolism/*surgery
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC5998853
COIS- Conflict of interest: None declared.
EDAT- 2018/04/05 06:00
MHDA- 2019/05/11 06:00
PMCR- 2018/04/01
CRDT- 2018/04/05 06:00
PHST- 2018/04/05 06:00 [entrez]
PHST- 2018/04/05 06:00 [pubmed]
PHST- 2019/05/11 06:00 [medline]
PHST- 2018/04/01 00:00 [pmc-release]
AID - AJC-19-273 [pii]
AID - 10.14744/AnatolJCardiol.2018.37929 [doi]
PST - ppublish
SO  - Anatol J Cardiol. 2018 Apr;19(4):273-278. doi: 
      10.14744/AnatolJCardiol.2018.37929.