PMID- 29615787 OWN - NLM STAT- MEDLINE DCOM- 20190930 LR - 20190930 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 8 IP - 1 DP - 2018 Apr 3 TI - Serum brain-derived neurotrophic factor predicting reduction in pulse pressure after a one-hour rest in nurses working night shifts. PG - 5485 LID - 10.1038/s41598-018-23791-8 [doi] LID - 5485 AB - Night shift work is associated with cardiovascular disease and central nervous system disorders in female nurses. Brain-derived neurotrophic factor (BDNF) exerts protective effects on neural and endothelial functions. This study examined the association between serum BDNF levels and pulse pressure after rest in female nurses working night shifts. In this study, blood samples were collected for BDNF measurement after a night shift when nurses had been working night shifts for three continuous weeks. Blood pressure was assessed before and after a one-hour morning rest within a week of resuming the night shift after one month without any night shift work. The pulse pressure of nurses (n = 48, age 29 +/- 5 years) was significantly reduced (from 43 +/- 7 to 41 +/- 6 mmHg, P = 0.003) after rest, and serum BDNF were significantly and inversely correlated with pulse pressure changes (r = -0.435, P = 0.002). Higher serum BDNF was an independent factor for greater reduction in pulse pressure (95%CI = -0.609 ‒ -0.174, P = 0.001). Using a receiver operating characteristic curve analysis, serum BDNF >20.6 ng/mL predicted a pulse pressure reduction after a one-hour rest (sensitivity 66.7%, specificity 77.8%). In conclusion, higher serum BDNF predicted greater recovery of pulse pressure after a one-hour rest in female nurses after night shift work. FAU - Lee, I-Te AU - Lee IT AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan. itlee@vghtc.gov.tw. AD - School of Medicine, National Yang-Ming University, Taipei, Taiwan. itlee@vghtc.gov.tw. AD - School of Medicine, Chung Shan Medical University, Taichung, Taiwan. itlee@vghtc.gov.tw. FAU - Sheu, Wayne Huey-Herng AU - Sheu WH AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan. AD - School of Medicine, National Yang-Ming University, Taipei, Taiwan. AD - School of Medicine, Chung Shan Medical University, Taichung, Taiwan. FAU - Lee, Wen-Jane AU - Lee WJ AD - Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan. FAU - Chen, Der-Yuan AU - Chen DY AD - School of Medicine, National Yang-Ming University, Taipei, Taiwan. AD - Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan. AD - PhD Program in Translational Medicine and Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, Taiwan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20180403 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Brain-Derived Neurotrophic Factor) SB - IM MH - Adult MH - *Blood Pressure MH - Brain-Derived Neurotrophic Factor/*blood MH - Female MH - Humans MH - *Nurses MH - *Rest MH - *Shift Work Schedule PMC - PMC5882896 COIS- The authors declare no competing interests. EDAT- 2018/04/05 06:00 MHDA- 2019/10/01 06:00 PMCR- 2018/04/03 CRDT- 2018/04/05 06:00 PHST- 2017/08/30 00:00 [received] PHST- 2018/03/21 00:00 [accepted] PHST- 2018/04/05 06:00 [entrez] PHST- 2018/04/05 06:00 [pubmed] PHST- 2019/10/01 06:00 [medline] PHST- 2018/04/03 00:00 [pmc-release] AID - 10.1038/s41598-018-23791-8 [pii] AID - 23791 [pii] AID - 10.1038/s41598-018-23791-8 [doi] PST - epublish SO - Sci Rep. 2018 Apr 3;8(1):5485. doi: 10.1038/s41598-018-23791-8.