PMID- 29615873 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20201001 IS - 1662-5129 (Print) IS - 1662-5129 (Electronic) IS - 1662-5129 (Linking) VI - 12 DP - 2018 TI - Alterations of White Matter Integrity and Hippocampal Functional Connectivity in Type 2 Diabetes Without Mild Cognitive Impairment. PG - 21 LID - 10.3389/fnana.2018.00021 [doi] LID - 21 AB - Aims: To investigate the white matter (WM) integrity and hippocampal functional connectivity (FC) in type 2 diabetes mellitus (T2DM) patients without mild cognitive impairment (MCI) by using diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (rs-fMRI), respectively. Methods: Twelve T2DM patients without MCI and 24 age, sex and education matched healthy controls (HC) were recruited. DTI and rs-fMRI data were subsequently acquired on a 3.0T MR scanner. Tract-based spatial statistics (TBSS) combining region of interests (ROIs) analysis was used to investigate the alterations of DTI metrics (fractional anisotropy (FA), mean diffusivity (MD), lambda(1) and lambda(23)) and FC measurement was performed to calculate hippocampal FC with other brain regions. Cognitive function was evaluated by using Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). Brain volumes were also evaluated among these participants. Results: There were no difference of MMSE and MoCA scores between two groups. Neither whole brain nor regional brain volume decrease was revealed in T2DM patients without MCI. DTI analysis revealed extensive WM disruptions, especially in the body of corpus callosum (CC). Significant decreases of hippocampal FC with certain brain structures were revealed, especially with the bilateral frontal cortex. Furthermore, the decreased FA in left posterior thalamic radiation (PTR) and increased MD in the splenium of CC were closely related with the decreased hippocampal FC to caudate nucleus and frontal cortex. Conclusions: T2DM patients without MCI showed extensive WM disruptions and abnormal hippocampal FC. Moreover, the WM disruptions and abnormal hippocampal FC were closely associated. Highlights -T2DM patients without MCI demonstrated no obvious brain volume decrease.-Extensive white matter disruptions, especially within the body of corpus callosum, were revealed with DTI analysis among the T2DM patients.-Despite no MCI in T2DM patients, decreased functional connectivity between hippocampal region and some critical brain regions were detected.-The alterations in hippocampal functional connectivity were closely associated with those of the white matter structures in T2DM patients. This trial was registered to ClinicalTrials.gov (NCT02420470, https://www.clinicaltrials.gov/). FAU - Sun, Qian AU - Sun Q AD - Department of Radiology & Functional and Molecular Imaging, Key Lab of Shaanxi Province, Tangdu Hospital, The Military Medical University of PLA Airforce (Fourth Military Medical University), Xi'an, China. FAU - Chen, Guan-Qun AU - Chen GQ AD - Department of Neurology, XuanWu Hospital, Capital Medical University, Beijing, China. FAU - Wang, Xi-Bin AU - Wang XB AD - Department of Medical Image Diagnosis, Hanzhong Central Hospital, Hanzhong, China. FAU - Yu, Ying AU - Yu Y AD - Department of Radiology & Functional and Molecular Imaging, Key Lab of Shaanxi Province, Tangdu Hospital, The Military Medical University of PLA Airforce (Fourth Military Medical University), Xi'an, China. FAU - Hu, Yu-Chuan AU - Hu YC AD - Department of Radiology & Functional and Molecular Imaging, Key Lab of Shaanxi Province, Tangdu Hospital, The Military Medical University of PLA Airforce (Fourth Military Medical University), Xi'an, China. FAU - Yan, Lin-Feng AU - Yan LF AD - Department of Radiology & Functional and Molecular Imaging, Key Lab of Shaanxi Province, Tangdu Hospital, The Military Medical University of PLA Airforce (Fourth Military Medical University), Xi'an, China. FAU - Zhang, Xin AU - Zhang X AD - Department of Radiology & Functional and Molecular Imaging, Key Lab of Shaanxi Province, Tangdu Hospital, The Military Medical University of PLA Airforce (Fourth Military Medical University), Xi'an, China. FAU - Yang, Yang AU - Yang Y AD - Department of Radiology & Functional and Molecular Imaging, Key Lab of Shaanxi Province, Tangdu Hospital, The Military Medical University of PLA Airforce (Fourth Military Medical University), Xi'an, China. FAU - Zhang, Jin AU - Zhang J AD - Department of Radiology & Functional and Molecular Imaging, Key Lab of Shaanxi Province, Tangdu Hospital, The Military Medical University of PLA Airforce (Fourth Military Medical University), Xi'an, China. FAU - Liu, Bin AU - Liu B AD - Student Brigade, The Military Medical University of PLA Airforce (Fourth Military Medical University), Xi'an, China. FAU - Wang, Cong-Cong AU - Wang CC AD - Student Brigade, The Military Medical University of PLA Airforce (Fourth Military Medical University), Xi'an, China. FAU - Ma, Yi AU - Ma Y AD - Student Brigade, The Military Medical University of PLA Airforce (Fourth Military Medical University), Xi'an, China. FAU - Wang, Wen AU - Wang W AD - Department of Radiology & Functional and Molecular Imaging, Key Lab of Shaanxi Province, Tangdu Hospital, The Military Medical University of PLA Airforce (Fourth Military Medical University), Xi'an, China. FAU - Han, Ying AU - Han Y AD - Department of Neurology, XuanWu Hospital, Capital Medical University, Beijing, China. FAU - Cui, Guang-Bin AU - Cui GB AD - Department of Radiology & Functional and Molecular Imaging, Key Lab of Shaanxi Province, Tangdu Hospital, The Military Medical University of PLA Airforce (Fourth Military Medical University), Xi'an, China. LA - eng SI - ClinicalTrials.gov/NCT02420470 PT - Journal Article DEP - 20180320 PL - Switzerland TA - Front Neuroanat JT - Frontiers in neuroanatomy JID - 101477943 PMC - PMC5869188 OTO - NOTNLM OT - functional connectivity (FC) OT - hippocampal OT - resting-state functional magnetic resonance imaging (rs-fMRI) OT - tract-based spatial statistics (TBSS) OT - type 2 diabetes mellitus (T2DM) EDAT- 2018/04/05 06:00 MHDA- 2018/04/05 06:01 PMCR- 2018/01/01 CRDT- 2018/04/05 06:00 PHST- 2017/02/09 00:00 [received] PHST- 2018/03/06 00:00 [accepted] PHST- 2018/04/05 06:00 [entrez] PHST- 2018/04/05 06:00 [pubmed] PHST- 2018/04/05 06:01 [medline] PHST- 2018/01/01 00:00 [pmc-release] AID - 10.3389/fnana.2018.00021 [doi] PST - epublish SO - Front Neuroanat. 2018 Mar 20;12:21. doi: 10.3389/fnana.2018.00021. eCollection 2018.