PMID- 29616085
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200930
IS  - 1792-0981 (Print)
IS  - 1792-1015 (Electronic)
IS  - 1792-0981 (Linking)
VI  - 15
IP  - 4
DP  - 2018 Apr
TI  - Assessment of telomerase activity in leukocytes of type 2 diabetes mellitus 
      patients having or not foot ulcer: Possible correlation with other clinical 
      parameters.
PG  - 3420-3424
LID - 10.3892/etm.2018.5798 [doi]
AB  - Telomerase is the enzyme that maintains telomere length by adding telomeric 
      repeats after each cell division. Numerous metabolic factors such as obesity, 
      insulin resistance or physical inactivity have been associated with shortened 
      telomeres. In the present study, we assessed telomerase activity in diabetic 
      patients having or not foot ulcer. A total of 90 adult patients with type 2 
      diabetes mellitus (T2DM) were studied. Patients were allocated into two groups 
      according to the absence or presence of active foot ulcers as follows: Nuon-ulcer 
      group (N=58) and ulcer group (N=32). Our data revealed that the patients with 
      diabetic ulcers had significantly greater waist circumference and neuropathy 
      disability score, while exhibiting lower telomerase activity, indicating the 
      possible existence of a common clinical profile among ulcer-bearing diabetic 
      patients. Validation of our findings by extending the study in larger patient 
      groups may contribute to the understanding of T2DM pathophysiology and its main 
      clinical implications.
FAU - Baltzis, Dimitrios
AU  - Baltzis D
AD  - Diabetes Center, Papageorgiou General Hospital, 56403 Thessaloniki, Greece.
AD  - Third Department of Internal Medicine, Papageorgiou General Hospital, 56403 
      Thessaloniki, Greece.
FAU - Meimeti, Evangelia
AU  - Meimeti E
AD  - Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of 
      Pharmacy, School of Health Sciences, National and Kapodistrian University of 
      Athens, 15771 Athens, Greece.
FAU - Grammatikopoulou, Maria G
AU  - Grammatikopoulou MG
AD  - Department of Nutrition and Dietetics, Alexander Technological Educational 
      Institute, 57400 Thessaloniki, Greece.
FAU - Roustit, Matthieu
AU  - Roustit M
AD  - HP2 Laboratory, University of Grenoble Alpes, 38700 La Tronche Universite 
      Grenoble Alpes, France.
FAU - Mavrogonatou, Eleni
AU  - Mavrogonatou E
AD  - Laboratory of Cell Proliferation and Ageing, Institute of Biosciences and 
      Applications, National Centre for Scientific Research 'Demokritos', 15341 Athens, 
      Greece.
FAU - Kletsas, Dimitris
AU  - Kletsas D
AD  - Laboratory of Cell Proliferation and Ageing, Institute of Biosciences and 
      Applications, National Centre for Scientific Research 'Demokritos', 15341 Athens, 
      Greece.
FAU - Efraimidou, Smaragda
AU  - Efraimidou S
AD  - Department of Hematology, Papageorgiou General Hospital, 56403 Thessaloniki, 
      Greece.
FAU - Manes, Christos
AU  - Manes C
AD  - Diabetes Center, Papageorgiou General Hospital, 56403 Thessaloniki, Greece.
FAU - Nikolouzakis, Taxiarchis K
AU  - Nikolouzakis TK
AD  - Laboratory of Anatomy-Histology-Embryology, Medical School, University of Crete, 
      71003 Heraklion, Greece.
FAU - Tsiaoussis, John
AU  - Tsiaoussis J
AD  - Laboratory of Anatomy-Histology-Embryology, Medical School, University of Crete, 
      71003 Heraklion, Greece.
FAU - Tsatsakis, Aristides M
AU  - Tsatsakis AM
AD  - Department of Forensic Sciences and Toxicology, Medical School, University of 
      Crete, 71003 Heraklion, Greece.
FAU - Spandidos, Demetrios A
AU  - Spandidos DA
AD  - Laboratory of Clinical Virology, Medical School, University of Crete, 71003 
      Heraklion, Greece.
FAU - Trakatelli, Christina-Maria
AU  - Trakatelli CM
AD  - Third Department of Internal Medicine, Papageorgiou General Hospital, 56403 
      Thessaloniki, Greece.
FAU - Drakoulis, Nikolaos
AU  - Drakoulis N
AD  - Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of 
      Pharmacy, School of Health Sciences, National and Kapodistrian University of 
      Athens, 15771 Athens, Greece.
LA  - eng
PT  - Journal Article
DEP - 20180125
PL  - Greece
TA  - Exp Ther Med
JT  - Experimental and therapeutic medicine
JID - 101531947
PMC - PMC5876498
OTO - NOTNLM
OT  - diabetic peripheral neuropathy
OT  - neuropathy disability score
OT  - oxidative damage
OT  - telomere-diabetes
EDAT- 2018/04/05 06:00
MHDA- 2018/04/05 06:01
PMCR- 2018/01/25
CRDT- 2018/04/05 06:00
PHST- 2017/09/20 00:00 [received]
PHST- 2017/12/25 00:00 [accepted]
PHST- 2018/04/05 06:00 [entrez]
PHST- 2018/04/05 06:00 [pubmed]
PHST- 2018/04/05 06:01 [medline]
PHST- 2018/01/25 00:00 [pmc-release]
AID - ETM-0-0-5798 [pii]
AID - 10.3892/etm.2018.5798 [doi]
PST - ppublish
SO  - Exp Ther Med. 2018 Apr;15(4):3420-3424. doi: 10.3892/etm.2018.5798. Epub 2018 Jan 
      25.