PMID- 29616203
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20201001
IS  - 2296-2360 (Print)
IS  - 2296-2360 (Electronic)
IS  - 2296-2360 (Linking)
VI  - 6
DP  - 2018
TI  - Non-Invasive Brain Stimulation in Children With Unilateral Cerebral Palsy: A 
      Protocol and Risk Mitigation Guide.
PG  - 56
LID - 10.3389/fped.2018.00056 [doi]
LID - 56
AB  - Non-invasive brain stimulation has been increasingly investigated, mainly in 
      adults, with the aims of influencing motor recovery after stroke. However, a 
      consensus on safety and optimal study design has not been established in 
      pediatrics. The low incidence of reported major adverse events in adults with and 
      without clinical conditions has expedited the exploration of NIBS in children 
      with paralleled purposes to influence motor skill development after neurological 
      injury. Considering developmental variability in children, with or without a 
      neurologic diagnosis, adult dosing and protocols may not be appropriate. The 
      purpose of this paper is to present recommendations and tools for the prevention 
      and mitigation of adverse events (AEs) during NIBS in children with unilateral 
      cerebral palsy (UCP). Our recommendations provide a framework for pediatric NIBS 
      study design. The key components of this report on NIBS AEs are (a) a summary of 
      related literature to provide the background evidence and (b) tools for 
      anticipating and managing AEs from four international pediatric laboratories. 
      These recommendations provide a preliminary guide for the assessment of safety 
      and risk mitigation of NIBS in children with UCP. Consistent reporting of safety, 
      feasibility, and tolerability will refine NIBS practice guidelines contributing 
      to future clinical translations of NIBS.
FAU - Gillick, Bernadette T
AU  - Gillick BT
AD  - Physical Therapy Division, Department of Rehabilitation Medicine, University of 
      Minnesota, Minneapolis, MN, United States.
FAU - Gordon, Andrew M
AU  - Gordon AM
AD  - Department of Biobehavioral Sciences, Teachers College, Columbia University, New 
      York, NY, United States.
FAU - Feyma, Tim
AU  - Feyma T
AD  - Gillette Children's Specialty Healthcare, Pediatric Neurology, St. Paul, MN, 
      United States.
FAU - Krach, Linda E
AU  - Krach LE
AD  - Courage Kenny Rehabilitation Institute, Minneapolis, MN, United States.
FAU - Carmel, Jason
AU  - Carmel J
AD  - Weill-Cornell Medical College, Blythedale Children's Hospital, Burke Medical 
      Research Institute, White Plains, NY, United States.
FAU - Rich, Tonya L
AU  - Rich TL
AD  - Rehabilitation Science, University of Minnesota, Minneapolis, MN, United States.
FAU - Bleyenheuft, Yannick
AU  - Bleyenheuft Y
AD  - Institute of Neuroscience (IoNS), Universite catholique de Louvain, Brussels, 
      Belgium.
FAU - Friel, Kathleen
AU  - Friel K
AD  - Weill-Cornell Medical College, Blythedale Children's Hospital, Burke Medical 
      Research Institute, White Plains, NY, United States.
LA  - eng
GR  - UL1 RR033183/RR/NCRR NIH HHS/United States
GR  - K08 NS073796/NS/NINDS NIH HHS/United States
GR  - TL1 RR024158/RR/NCRR NIH HHS/United States
GR  - UL1 TR000114/TR/NCATS NIH HHS/United States
GR  - K01 HD078484/HD/NICHD NIH HHS/United States
GR  - KL2 RR024157/RR/NCRR NIH HHS/United States
GR  - R01 HD076436/HD/NICHD NIH HHS/United States
GR  - K01 NS062116/NS/NINDS NIH HHS/United States
GR  - UL1 RR024156/RR/NCRR NIH HHS/United States
PT  - Journal Article
DEP - 20180316
PL  - Switzerland
TA  - Front Pediatr
JT  - Frontiers in pediatrics
JID - 101615492
PMC - PMC5864860
OTO - NOTNLM
OT  - cerebral palsy
OT  - children
OT  - non-invasive brain stimulation
OT  - repetitive transcranial magnetic stimulation
OT  - risk
OT  - safety
OT  - transcranial direct current stimulation
OT  - transcranial magnetic stimulation
EDAT- 2018/04/05 06:00
MHDA- 2018/04/05 06:01
PMCR- 2018/03/16
CRDT- 2018/04/05 06:00
PHST- 2017/08/25 00:00 [received]
PHST- 2018/02/26 00:00 [accepted]
PHST- 2018/04/05 06:00 [entrez]
PHST- 2018/04/05 06:00 [pubmed]
PHST- 2018/04/05 06:01 [medline]
PHST- 2018/03/16 00:00 [pmc-release]
AID - 10.3389/fped.2018.00056 [doi]
PST - epublish
SO  - Front Pediatr. 2018 Mar 16;6:56. doi: 10.3389/fped.2018.00056. eCollection 2018.