PMID- 29617002
OWN - NLM
STAT- MEDLINE
DCOM- 20190320
LR  - 20190401
IS  - 1664-5502 (Electronic)
IS  - 1664-3828 (Print)
IS  - 1664-5502 (Linking)
VI  - 8
IP  - 2
DP  - 2018
TI  - The Role of Dendritic and Endothelial Cells in Cardiorenal Syndrome.
PG  - 92-104
LID - 10.1159/000485937 [doi]
AB  - BACKGROUNDS: Dendritic cells (DCs) are antigen-presenting cells that play a 
      central role in innate and adaptive immune responses; however, the cross talk 
      between cardiac and renal DCs in cardiorenal syndrome (CRS) has not yet been 
      fully elucidated. In this setting, endothelial cells (ECs) also contribute to 
      immune responses. SUMMARY: DC and EC activation and dysfunction have a central 
      role in the pathogenesis of CRS. Regarding immune responses in CRS, it is unknown 
      whether ECs may serve as antigen-presenting cells or act synergistically with DCs 
      to actively participate in innate and adaptive immune responses. This review 
      first focuses on the burden of concomitant heart and renal DCs in the context of 
      CRS; it examines what is known of DCs in animal models, and proposes a central 
      role for DCs in all types of CRS. Second, this review briefly describes the role 
      of ECs in the context of CRS. Key Messages: Understanding the role of DCs and ECs 
      in immune response could lead to the development of novel therapies for the 
      prevention and treatment of CRS.
CI  - (c) 2018 S. Karger AG, Basel.
FAU - Virzi, Grazia Maria
AU  - Virzi GM
AD  - Department of Nephrology, Dialysis and Transplant, San Bortolo Hospital, Vicenza, 
      Italy.
AD  - IRRIV-International Renal Research Institute Vicenza, Vicenza, Italy.
FAU - Zhang, Jun
AU  - Zhang J
AD  - Baylor Heart and Vascular Institute, Dallas, Texas, USA.
FAU - Nalesso, Federico
AU  - Nalesso F
AD  - Department of Nephrology, Dialysis and Transplant, San Bortolo Hospital, Vicenza, 
      Italy.
AD  - IRRIV-International Renal Research Institute Vicenza, Vicenza, Italy.
FAU - Ronco, Claudio
AU  - Ronco C
AD  - Department of Nephrology, Dialysis and Transplant, San Bortolo Hospital, Vicenza, 
      Italy.
AD  - IRRIV-International Renal Research Institute Vicenza, Vicenza, Italy.
FAU - McCullough, Peter A
AU  - McCullough PA
AD  - Baylor Heart and Vascular Institute, Dallas, Texas, USA.
AD  - Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas, 
      USA.
AD  - Baylor Jack and Jane Hamilton Heart and Vascular Hospital, Dallas, Texas, USA.
AD  - The Heart Hospital, Plano, Texas, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20180122
PL  - Switzerland
TA  - Cardiorenal Med
JT  - Cardiorenal medicine
JID - 101554863
SB  - IM
MH  - Antigen Presentation/*immunology
MH  - Cardio-Renal Syndrome/*immunology
MH  - Dendritic Cells/*immunology
MH  - Endothelial Cells/*immunology
MH  - Humans
MH  - *Immunity, Cellular
PMC - PMC5968234
OTO - NOTNLM
OT  - Antigen-presenting cells
OT  - Cardiorenal syndrome
OT  - Dendritic cells
OT  - Endothelial cells
OT  - Endothelial dysfunction
OT  - Immune dysregulation
EDAT- 2018/04/05 06:00
MHDA- 2019/03/21 06:00
PMCR- 2019/04/01
CRDT- 2018/04/05 06:00
PHST- 2017/08/31 00:00 [received]
PHST- 2017/11/29 00:00 [accepted]
PHST- 2018/04/05 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2018/04/05 06:00 [entrez]
PHST- 2019/04/01 00:00 [pmc-release]
AID - 000485937 [pii]
AID - crm-0008-0092 [pii]
AID - 10.1159/000485937 [doi]
PST - ppublish
SO  - Cardiorenal Med. 2018;8(2):92-104. doi: 10.1159/000485937. Epub 2018 Jan 22.