PMID- 29617006
OWN - NLM
STAT- MEDLINE
DCOM- 20190320
LR  - 20190401
IS  - 1664-5502 (Electronic)
IS  - 1664-3828 (Print)
IS  - 1664-5502 (Linking)
VI  - 8
IP  - 2
DP  - 2018
TI  - Relevance of B-Lines on Lung Ultrasound in Volume Overload and Pulmonary 
      Congestion: Clinical Correlations and Outcomes in Patients on Hemodialysis.
PG  - 83-91
LID - 10.1159/000476000 [doi]
AB  - BACKGROUND: Volume overload in patients on hemodialysis (HD) is an independent 
      risk factor for cardiovascular mortality. B-lines detected on lung ultrasound 
      (BLUS) assess extravascular lung water. This raises interest in its utility for 
      assessing volume status and cardiovascular outcomes. METHODS: End-stage renal 
      disease patients on HD at the Island Rehab Center being older than 18 years were 
      screened. Patients achieving their dry weight (DW) had a lung ultrasound in a 
      supine position. Scores were classified as mild (0-14), moderate (15-30), and 
      severe (>30) for pulmonary congestion. Patients with more than 60 were further 
      classified as very severe. Patients were followed for cardiac events and death. 
      RESULTS: 81 patients were recruited. 58 were males, with a mean age of 59.7 
      years. 44 had New York Heart Association (NYHA) class 1, 24 had class 2, and 13 
      had class 3. In univariate analysis, NYHA class was associated with B-line 
      classes (<0.001) and diastolic dysfunction (0.002). In multivariate analysis, 
      NYHA grade strongly correlated with B-line classification (0.01) but not with 
      heart function (0.95). 71 subjects were followed for a mean duration of 1.19 
      years. 9 patients died and 20 had an incident cardiac event. A Kaplan-Meier 
      survival analysis demonstrated an interval decrease in survival times in 
      all-cause mortality and cardiac events with increased BLUS scores (p = 0.0049). 
      Multivariate Cox regression analysis showed the independent predictive value of 
      BLUS class for mortality and cardiac events with a heart rate of 2.98 and 7.98 in 
      severe and very severe classes, respectively, compared to patients in the mild 
      class (p = 0.025 and 0.013). CONCLUSION: At DW, BLUS is an independent risk 
      factor for death and cardiovascular events in patients on HD.
CI  - (c) 2017 S. Karger AG, Basel.
FAU - Saad, Marc M
AU  - Saad MM
FAU - Kamal, Jeanne
AU  - Kamal J
FAU - Moussaly, Elias
AU  - Moussaly E
FAU - Karam, Boutros
AU  - Karam B
FAU - Mansour, Wissam
AU  - Mansour W
FAU - Gobran, Emad
AU  - Gobran E
FAU - Abbasi, Saqib Hussen
AU  - Abbasi SH
FAU - Mahgoub, Ahmed
AU  - Mahgoub A
FAU - Singh, Puja
AU  - Singh P
FAU - Hardy, Ross
AU  - Hardy R
FAU - Das, Devjani
AU  - Das D
FAU - Brown, Cara
AU  - Brown C
FAU - Kapoor, Monica
AU  - Kapoor M
FAU - Demissie, Seleshi
AU  - Demissie S
FAU - Kleiner, Morton J
AU  - Kleiner MJ
FAU - El Charabaty, Elie
AU  - El Charabaty E
FAU - El Sayegh, Suzanne E
AU  - El Sayegh SE
LA  - eng
PT  - Journal Article
DEP - 20171129
PL  - Switzerland
TA  - Cardiorenal Med
JT  - Cardiorenal medicine
JID - 101554863
SB  - IM
MH  - Extravascular Lung Water/*diagnostic imaging
MH  - Female
MH  - Humans
MH  - Kidney Failure, Chronic/complications/*therapy
MH  - Lung/*diagnostic imaging
MH  - Male
MH  - Middle Aged
MH  - Pulmonary Circulation
MH  - Pulmonary Edema/*diagnosis/etiology/physiopathology
MH  - *Renal Dialysis
MH  - Ultrasonography/*methods
PMC - PMC5968278
OTO - NOTNLM
OT  - Cardiovascular outcomes
OT  - Hemodialysis
OT  - Lung ultrasound
OT  - Volume overload
EDAT- 2018/04/05 06:00
MHDA- 2019/03/21 06:00
PMCR- 2019/04/01
CRDT- 2018/04/05 06:00
PHST- 2016/12/20 00:00 [received]
PHST- 2017/04/17 00:00 [accepted]
PHST- 2018/04/05 06:00 [pubmed]
PHST- 2019/03/21 06:00 [medline]
PHST- 2018/04/05 06:00 [entrez]
PHST- 2019/04/01 00:00 [pmc-release]
AID - 000476000 [pii]
AID - crm-0008-0083 [pii]
AID - 10.1159/000476000 [doi]
PST - ppublish
SO  - Cardiorenal Med. 2018;8(2):83-91. doi: 10.1159/000476000. Epub 2017 Nov 29.