PMID- 29618696
OWN - NLM
STAT- MEDLINE
DCOM- 20191017
LR  - 20191017
IS  - 1347-4820 (Electronic)
IS  - 1346-9843 (Linking)
VI  - 82
IP  - 7
DP  - 2018 Jun 25
TI  - Subclinical Leaflet Thrombosis in Transcatheter Aortic Valve Replacement Detected 
      by Multidetector Computed Tomography　- A Review of Current Evidence.
PG  - 1735-1742
LID - 10.1253/circj.CJ-17-1363 [doi]
AB  - Subclinical leaflet thrombosis (SLT) following transcatheter aortic valve 
      replacement (TAVR) has been increasingly recognized. SLT has the hallmark 
      features of hypo-attenuated leaflet thickening (HALT) on multidetector computed 
      tomography (MDCT), which may result in hypoattenuation affecting motion (HAM). 
      The actual prevalence of this condition is uncertain, with limited observational 
      registries. SLT has caught the attention of the cardiovascular community because 
      of concerns regarding its clinical sequelae, specifically the potential increased 
      incidence of cerebrovascular events. There are available, albeit sparse, data to 
      suggest that when left untreated, SLT may lead to valve deterioration with 
      potential hemodynamic compromise and potentially clinically overt prostheses 
      thrombosis. Some clinicians have opted to treat patients with SLT with 
      anticoagulation. Although anticoagulation may be a rational treatment option, 
      little data exist on the safety and efficacy of this treatment. This is 
      particularly important considering TAVR patients also have higher bleeding risk 
      than the standard population. In this review, we aim to summarize the current 
      evidence on SLT, explore its pathophysiological mechanism, discuss the current 
      treatment options and future trials that may clarify the optimal antithrombotic 
      strategies of SLT.
FAU - Rashid, Hashrul N
AU  - Rashid HN
AD  - Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash 
      Health.
FAU - Brown, Adam J
AU  - Brown AJ
AD  - Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash 
      Health.
FAU - McCormick, Liam M
AU  - McCormick LM
AD  - Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash 
      Health.
FAU - Amiruddin, Ameera S
AU  - Amiruddin AS
AD  - Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash 
      Health.
FAU - Be, Kim K
AU  - Be KK
AD  - Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash 
      Health.
FAU - Cameron, James D
AU  - Cameron JD
AD  - Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash 
      Health.
FAU - Nasis, Arthur
AU  - Nasis A
AD  - Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash 
      Health.
FAU - Gooley, Robert P
AU  - Gooley RP
AD  - Monash Cardiovascular Research Centre, Monash University and MonashHeart, Monash 
      Health.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180404
PL  - Japan
TA  - Circ J
JT  - Circulation journal : official journal of the Japanese Circulation Society
JID - 101137683
RN  - 0 (Anticoagulants)
SB  - IM
MH  - Anticoagulants/therapeutic use
MH  - Hemorrhage/etiology
MH  - Humans
MH  - Multidetector Computed Tomography/*methods
MH  - Thrombosis/*diagnosis/drug therapy/physiopathology
MH  - Transcatheter Aortic Valve Replacement/adverse effects/*methods
OTO - NOTNLM
OT  - Aortic stenosis
OT  - Thrombosis
OT  - Transcatheter aortic valve replacement/implantation
EDAT- 2018/04/06 06:00
MHDA- 2019/10/18 06:00
CRDT- 2018/04/06 06:00
PHST- 2018/04/06 06:00 [pubmed]
PHST- 2019/10/18 06:00 [medline]
PHST- 2018/04/06 06:00 [entrez]
AID - 10.1253/circj.CJ-17-1363 [doi]
PST - ppublish
SO  - Circ J. 2018 Jun 25;82(7):1735-1742. doi: 10.1253/circj.CJ-17-1363. Epub 2018 Apr 
      4.