PMID- 29619104
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1809-9777 (Print)
IS  - 1809-4864 (Electronic)
IS  - 1809-4864 (Linking)
VI  - 22
IP  - 2
DP  - 2018 Apr
TI  - The Role of the Level of Interleukin-33 in the Therapeutic Outcomes of 
      Immunotherapy in Patients with Allergic Rhinitis.
PG  - 152-156
LID - 10.1055/s-0037-1605596 [doi]
AB  - Introduction  Allergic rhinitis (AR) affects up to 40% of the population and 
      results in nasal itching, congestion, sneezing, and clear rhinorrhea. Objectives 
       This study aimed to evaluate the changes in the clinical symptoms and in the 
      level of serum interleukin (IL)-33 before and after pollen immunotherapy (IT) in 
      patients with AR. Methods  The total symptom score and the levels of total 
      immunoglobulin E (IgE) and IL-33 were determined in the serum of 10 non-allergic 
      healthy controls and 45 patients with AR who were equally divided into 3 groups: 
      GI (patients did not receive IT), GII (patients had received IT for 6 months) and 
      GIII (patients had received IT for 2 years). Results  There was a significantly 
      higher concentration of IgE and IL-33 in the serum of patients with AR than in 
      that of non-allergic patients. Furthermore, serum level of IL-33 decreased 
      significantly after pollen IT. But, there was no significant reduction in the 
      serum level of IL-33 between GII and GIII patients. Conclusion  Our results show 
      a clinical improvement associated with a decrease in serum level of IL-33 after 
      pollen IT.
FAU - Nasr, Wail Fayez
AU  - Nasr WF
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Zagazig University 
      Faculty of Human Medicine, Zagazig, El Sharkeya, Egypt.
FAU - Sorour, Samir Sorour
AU  - Sorour SS
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Zagazig University 
      Faculty of Human Medicine, Zagazig, El Sharkeya, Egypt.
FAU - El Bahrawy, Atef Taha
AU  - El Bahrawy AT
AD  - Department of Otorhinolaryngology and Head and Neck Surgery, Zagazig University 
      Faculty of Human Medicine, Zagazig, El Sharkeya, Egypt.
FAU - Boghdadi, Ghada Samir
AU  - Boghdadi GS
AD  - Department of Microbiology and Immunology, Zagazig University Faculty of Human 
      Medicine, Zagazig, El Sharkeya, Egypt.
FAU - El Shahaway, Alia A
AU  - El Shahaway AA
AD  - Department of Microbiology and Immunology, Zagazig University Faculty of Human 
      Medicine, Zagazig, El Sharkeya, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20170828
PL  - Brazil
TA  - Int Arch Otorhinolaryngol
JT  - International archives of otorhinolaryngology
JID - 101637652
PMC - PMC5882380
OTO - NOTNLM
OT  - allergen immunotherapy
OT  - allergic rhinitis
OT  - helper T cells
OT  - immunotherapy
COIS- Conflict of Interest The authors report no conflict of interest.
EDAT- 2018/04/06 06:00
MHDA- 2018/04/06 06:01
PMCR- 2018/04/01
CRDT- 2018/04/06 06:00
PHST- 2016/10/19 00:00 [received]
PHST- 2017/07/03 00:00 [accepted]
PHST- 2018/04/06 06:00 [entrez]
PHST- 2018/04/06 06:00 [pubmed]
PHST- 2018/04/06 06:01 [medline]
PHST- 2018/04/01 00:00 [pmc-release]
AID - 0617or [pii]
AID - 10.1055/s-0037-1605596 [doi]
PST - ppublish
SO  - Int Arch Otorhinolaryngol. 2018 Apr;22(2):152-156. doi: 10.1055/s-0037-1605596. 
      Epub 2017 Aug 28.