PMID- 29619492
OWN - NLM
STAT- MEDLINE
DCOM- 20180928
LR  - 20181114
IS  - 1658-3175 (Electronic)
IS  - 0379-5284 (Print)
IS  - 0379-5284 (Linking)
VI  - 39
IP  - 4
DP  - 2018 Apr
TI  - Effects of Ramadan fasting on the symptoms of chronic heart failure.
PG  - 395-400
LID - 10.15537/smj.2018.4.22011 [doi]
AB  - OBJECTIVES: To investigate the effect of Ramadan fasting on the symptoms of 
      chronic heart failure with a reduced ejection fraction (HFrEF). Globally, more 
      than one billion Muslims fast during Ramadan. Data regarding the effect of 
      fasting in heart failure patients with a reduced ejection fraction are limited. 
      METHODS: We prospectively studied 249 outpatients with HFrEF who undertook 
      Ramadan fasting at tertiary care cardiac center in Saudi Arabia in 2017. We 
      obtained information regarding the clinical assessment, diagnosis, emergency 
      department visits, and hospitalization during and in the month preceding Ramadan. 
      RESULTS: We enrolled 249 patients, 227 (91%) undertook the fast for the entire 
      month. During Ramadan, 209 (92%) patients remained hemodynamically stable, 
      whereas 18 (8%) developed instability. The mean New York Heart Association (NYHA) 
      functional class was significantly lower in the stable than in the unstable group 
      (1.46+/-0.7 vs. 3.22+/-0.55, p less than 0.0001), although no intergroup differences 
      were observed before Ramadan. Patients from the unstable vs. the stable group 
      showed significantly less adherence to medications (67% vs. 94%, p less 
      than 0.0001) and to diet (39% vs. 79%, p less than 0.0001), and a lower 
      likelihood of demonstrating ischemic cardiomyopathy as an underlying etiology of 
      HFrEF (33% vs. 57%, p=0.046). Dependent t-test analysis including all patients 
      showed that the NYHA classification before Ramadan was significantly higher than 
      during Ramadan (2.19+/-0.9 vs. 1.6+/-0.8, t-value 8.5, p less than 0.0001). 
      CONCLUSION: In most patients with chronic HFrEF, Ramadan fasting is considered 
      safe. Non-adherence to medication and diet are significantly associated with 
      decompensated heart failure during Ramadan.
FAU - Abazid, Rami M
AU  - Abazid RM
AD  - Department of Cardiology, Prince Sultan Cardiac Center, Qassim, Buraydah, Kingdom 
      of Saudi Arabia. E-mail. ramiabazid@yahoo.com.
FAU - Khalaf, Hassan H
AU  - Khalaf HH
FAU - Sakr, Haitham I
AU  - Sakr HI
FAU - Altorbak, Nora A
AU  - Altorbak NA
FAU - Alenzi, Habiba S
AU  - Alenzi HS
FAU - Awad, Zaki M
AU  - Awad ZM
FAU - Smettei, Osama A
AU  - Smettei OA
FAU - Elsanan, Moataz A
AU  - Elsanan MA
FAU - Widyan, Adel M
AU  - Widyan AM
FAU - Azazy, Ahmed S
AU  - Azazy AS
FAU - Chamsi-Pasha, Hassan W
AU  - Chamsi-Pasha HW
LA  - eng
PT  - Journal Article
PL  - Saudi Arabia
TA  - Saudi Med J
JT  - Saudi medical journal
JID - 7909441
SB  - IM
CIN - Saudi Med J. 2018 Jun;39(6):632. PMID: 29915861
MH  - Adult
MH  - Aged
MH  - Chronic Disease
MH  - *Diet
MH  - Fasting/*adverse effects
MH  - Female
MH  - Heart Failure/drug therapy/*etiology/physiopathology
MH  - Humans
MH  - *Islam
MH  - Male
MH  - *Medication Adherence
MH  - Middle Aged
MH  - Prospective Studies
MH  - Saudi Arabia
MH  - Stroke Volume
MH  - Symptom Assessment
PMC - PMC5938654
EDAT- 2018/04/06 06:00
MHDA- 2018/10/03 06:00
PMCR- 2018/04/01
CRDT- 2018/04/06 06:00
PHST- 2018/04/06 06:00 [entrez]
PHST- 2018/04/06 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
PHST- 2018/04/01 00:00 [pmc-release]
AID - SaudiMedJ-39-395 [pii]
AID - 10.15537/smj.2018.4.22011 [doi]
PST - ppublish
SO  - Saudi Med J. 2018 Apr;39(4):395-400. doi: 10.15537/smj.2018.4.22011.