PMID- 29619752
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 1869-6953 (Print)
IS  - 1869-6961 (Electronic)
IS  - 1869-6961 (Linking)
VI  - 9
IP  - 3
DP  - 2018 Jun
TI  - Is a Previously or Currently Reduced Testosterone Level in Male Patients with 
      Type 2 Diabetes Mellitus a Risk Factor for the Development of Coronary Artery 
      Disease? A Systematic Review and Meta-analysis.
PG  - 1061-1072
LID - 10.1007/s13300-018-0415-3 [doi]
AB  - INTRODUCTION: We aimed to systematically investigate the association between 
      testosterone level and cardiovascular risk in male patients with type 2 diabetes 
      mellitus (T2DM) by comparing male T2DM patients with low testosterone levels to 
      male T2DM patients with normal testosterone levels at baseline in terms of the 
      number of cases of coronary artery disease (CAD). METHODS: Online databases were 
      carefully searched for studies relating to testosterone, diabetes mellitus, and 
      cardiovascular risk by using the search terms 'testosterone,' 'diabetes 
      mellitus,' and 'coronary artery/cardiovascular disease.' The only endpoint in 
      this analysis was CAD/atherosclerosis/coronary plaque/major adverse coronary 
      event prior to or following testosterone reduction at baseline. The analytical 
      parameters used in this analysis were the risk ratio (RR) with the 95% confidence 
      interval (CI), as obtained using the RevMan 5.3 software. RESULTS: 3467 male 
      patients with T2DM (1079 patients with a low testosterone level versus 2388 
      patients with a normal testosterone level) were included. The results of this 
      analysis showed that when a random effects model was used, a higher risk of 
      CAD/cardiovascular disease was observed in diabetic patients with a low 
      testosterone level than in those with a normal testosterone level (RR 1.24, 95% 
      CI 0.94-1.63; P = 0.13). However, the difference in risk was not statistically 
      significant. Similarly, with a fixed effects model, a low testosterone level was 
      associated with a higher CAD/cardiovascular risk of disease (RR 1.12, 95% CI 
      0.98-1.34; P = 0.08); in this case, the difference in risk between the T2DM 
      patients with low and normal testosterone levels approached statistical 
      significance. CONCLUSION: A previously or currently reduced testosterone level 
      was not found to be statistically significantly associated with a high risk of 
      CAD/cardiovascular disease in male patients with T2DM. However, the difference in 
      risk between the T2DM patients with low and normal testosterone levels was 
      observed to approach statistical significance.
FAU - Huang, Feng
AU  - Huang F
AUID- ORCID: 0000-0002-3269-7530
AD  - Institute of Cardiovascular Diseases and Guangxi Key Laboratory Base of Precision 
      Medicine in Cardio-cerebrovascular Diseases Control and Prevention, The First 
      Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, People's 
      Republic of China. huangfeng7925@163.com.
LA  - eng
PT  - Journal Article
DEP - 20180404
PL  - United States
TA  - Diabetes Ther
JT  - Diabetes therapy : research, treatment and education of diabetes and related 
      disorders
JID - 101539025
PMC - PMC5984918
OTO - NOTNLM
OT  - Cardiovascular disease
OT  - Coronary artery disease
OT  - Male
OT  - Testosterone
OT  - Type 2 diabetes mellitus
EDAT- 2018/04/06 06:00
MHDA- 2018/04/06 06:01
PMCR- 2018/04/04
CRDT- 2018/04/06 06:00
PHST- 2018/02/23 00:00 [received]
PHST- 2018/04/06 06:00 [pubmed]
PHST- 2018/04/06 06:01 [medline]
PHST- 2018/04/06 06:00 [entrez]
PHST- 2018/04/04 00:00 [pmc-release]
AID - 10.1007/s13300-018-0415-3 [pii]
AID - 415 [pii]
AID - 10.1007/s13300-018-0415-3 [doi]
PST - ppublish
SO  - Diabetes Ther. 2018 Jun;9(3):1061-1072. doi: 10.1007/s13300-018-0415-3. Epub 2018 
      Apr 4.