PMID- 29620200
OWN - NLM
STAT- MEDLINE
DCOM- 20180926
LR  - 20181114
IS  - 1791-3004 (Electronic)
IS  - 1791-2997 (Print)
IS  - 1791-2997 (Linking)
VI  - 17
IP  - 6
DP  - 2018 Jun
TI  - Identification of key genes and pathways in regulating immune‑induced diseases of 
      dendritic cells by bioinformatic analysis.
PG  - 7585-7594
LID - 10.3892/mmr.2018.8834 [doi]
AB  - Dendritic cells (DCs) serve crucial roles in the activation of the immune 
      response, and imbalance in the activation or inhibition of DCs has been 
      associated with an increased susceptibility to develop immune‑induced diseases. 
      However, the molecular mechanisms of regulating immune‑induced diseases of DCs 
      are not well understood. The aim of the present study was to identify the gene 
      signatures and uncover the potential regulatory mechanisms in DCs. A total of 4 
      gene expression profiles (GSE52894, GSE72893, GSE75938 and GSE77969) were 
      integrated and analyzed in depth. In total, 241 upregulated genes and 365 
      downregulated genes were detected. Gene ontology and pathway enrichment analysis 
      showed that the differentially expressed genes (DEGs) were significantly enriched 
      in the inflammatory response, the tumor necrosis factor (TNF) signaling pathway, 
      the nuclear factor (NF)‑kappaB signaling pathway and antigen processing. The top 10 
      hub genes were identified from the protein‑protein analysis. The most significant 
      2 modules were filtered from the protein‑protein network. The genes in 2 modules 
      were involved in type I interferon signaling, the NF‑kappaB signaling pathway and the 
      TNF signaling pathway. Furthermore, the microRNA‑mRNA network analysis was 
      performed. The results of the present study revealed that the identified DEGs and 
      pathways may improve our understanding of the mechanisms of the maturation of 
      DCs, and the candidate hub genes that may be therapeutic targets for 
      immune‑induced diseases.
FAU - Zheng, Yang
AU  - Zheng Y
AD  - Department of Cardiology, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150001, P.R. China.
FAU - Zheng, Xianghui
AU  - Zheng X
AD  - Department of Cardiology, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150001, P.R. China.
FAU - Li, Shuang
AU  - Li S
AD  - Department of Cardiology, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150001, P.R. China.
FAU - Zhang, Hanlu
AU  - Zhang H
AD  - Department of Cardiology, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150001, P.R. China.
FAU - Liu, Mingyang
AU  - Liu M
AD  - Department of Cardiology, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150001, P.R. China.
FAU - Yang, Qingyuan
AU  - Yang Q
AD  - Department of Cardiology, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150001, P.R. China.
FAU - Zhang, Maomao
AU  - Zhang M
AD  - Department of Cardiology, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150001, P.R. China.
FAU - Sun, Yong
AU  - Sun Y
AD  - Department of Cardiology, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150001, P.R. China.
FAU - Wu, Jian
AU  - Wu J
AD  - Department of Cardiology, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150001, P.R. China.
FAU - Yu, Bo
AU  - Yu B
AD  - Department of Cardiology, The Second Affiliated Hospital of Harbin Medical 
      University, Harbin, Heilongjiang 150001, P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20180329
PL  - Greece
TA  - Mol Med Rep
JT  - Molecular medicine reports
JID - 101475259
RN  - 0 (MicroRNAs)
SB  - IM
MH  - *Computational Biology/methods
MH  - Dendritic Cells/*immunology/*metabolism
MH  - Disease Susceptibility/*immunology
MH  - Gene Expression Profiling
MH  - Gene Ontology
MH  - Gene Regulatory Networks
MH  - *Genetic Predisposition to Disease
MH  - Host-Pathogen Interactions
MH  - Humans
MH  - MicroRNAs/genetics
MH  - Protein Interaction Mapping
MH  - Protein Interaction Maps
MH  - *Signal Transduction
PMC - PMC5983944
EDAT- 2018/04/06 06:00
MHDA- 2018/09/27 06:00
PMCR- 2018/03/29
CRDT- 2018/04/06 06:00
PHST- 2017/12/19 00:00 [received]
PHST- 2018/03/22 00:00 [accepted]
PHST- 2018/04/06 06:00 [pubmed]
PHST- 2018/09/27 06:00 [medline]
PHST- 2018/04/06 06:00 [entrez]
PHST- 2018/03/29 00:00 [pmc-release]
AID - mmr-17-06-7585 [pii]
AID - 10.3892/mmr.2018.8834 [doi]
PST - ppublish
SO  - Mol Med Rep. 2018 Jun;17(6):7585-7594. doi: 10.3892/mmr.2018.8834. Epub 2018 Mar 
      29.