PMID- 29620476
OWN - NLM
STAT- MEDLINE
DCOM- 20190806
LR  - 20190806
IS  - 1366-5804 (Electronic)
IS  - 1354-750X (Linking)
VI  - 24
IP  - 1
DP  - 2019 Feb
TI  - Association of pre-admission statin therapy and the inflammatory response in ST 
      elevation myocardial infarction patients.
PG  - 17-22
LID - 10.1080/1354750X.2018.1460765 [doi]
AB  - PURPOSE: To demonstrate the possible association of statin therapy with C 
      reactive protein (CRP) serial measurements in ST elevation myocardial infarction 
      (STEMI) patients. MATERIALS AND METHODS: STEMI patients between 2008 and 2016 
      with available CRP data from admission were divided into two groups according to 
      pre-admission statin therapy. A second CRP measurement was noted following 
      primary coronary intervention (within 24 h from admission). The difference 
      between the two measurements was designated DeltaCRP. RESULTS: The cohort consisted 
      of 1134 patients with a median age of 61 (IQR52-70), 81% males. Patients on 
      statins prior to admission (336/1134, 26%) were more likely to have CRP levels 
      within normal range (</=5 mg/l) compared to patients without prior treatment, both 
      at admission (75 vs. 24%, p = 0.004) and at 24 h (70 vs. 48%, p = 0.029). The 
      prevalence of patients with pre-admission statin therapy decreased as DeltaCRP 
      increased (p = 0.004; n = 301). The likelihood of DeltaCRP to be above 5 mg/l in 
      patients with pre-admission statin therapy was reduced after age and gender 
      adjustments (OR 0.54, 95% CI 0.32-0.92, p = 0.023) and in multivariate (OR 0.57, 
      95% CI 0.33-0.99, p = 0.048) analysis. CONCLUSIONS: Pre-admission statin therapy 
      is associated with a less robust inflammatory response in STEMI patients, 
      highlighting statin's pathophysiological importance.
FAU - Rozenbaum, Zach
AU  - Rozenbaum Z
AUID- ORCID: 0000-0003-4953-7696
AD  - a Department of Cardiology , Tel Aviv Sourasky Medical Center; Affiliated to the 
      Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
FAU - Ravid, Dor
AU  - Ravid D
AD  - a Department of Cardiology , Tel Aviv Sourasky Medical Center; Affiliated to the 
      Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
FAU - Margolis, Gilad
AU  - Margolis G
AD  - a Department of Cardiology , Tel Aviv Sourasky Medical Center; Affiliated to the 
      Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
FAU - Khoury, Shafik
AU  - Khoury S
AD  - a Department of Cardiology , Tel Aviv Sourasky Medical Center; Affiliated to the 
      Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
FAU - Kaufman, Natalia
AU  - Kaufman N
AD  - a Department of Cardiology , Tel Aviv Sourasky Medical Center; Affiliated to the 
      Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
FAU - Keren, Gad
AU  - Keren G
AD  - a Department of Cardiology , Tel Aviv Sourasky Medical Center; Affiliated to the 
      Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
FAU - Milwidsky, Assi
AU  - Milwidsky A
AUID- ORCID: 0000-0002-3319-0336
AD  - a Department of Cardiology , Tel Aviv Sourasky Medical Center; Affiliated to the 
      Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
FAU - Shacham, Yacov
AU  - Shacham Y
AD  - a Department of Cardiology , Tel Aviv Sourasky Medical Center; Affiliated to the 
      Sackler Faculty of Medicine, Tel Aviv University , Tel Aviv , Israel.
LA  - eng
PT  - Journal Article
DEP - 20181209
PL  - England
TA  - Biomarkers
JT  - Biomarkers : biochemical indicators of exposure, response, and susceptibility to 
      chemicals
JID - 9606000
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
RN  - 9007-41-4 (C-Reactive Protein)
MH  - Aged
MH  - C-Reactive Protein/*analysis
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*therapeutic use
MH  - *Inflammation/diagnosis
MH  - Male
MH  - Middle Aged
MH  - Premedication
MH  - ST Elevation Myocardial Infarction/*pathology/therapy
OTO - NOTNLM
OT  - CRP
OT  - STEMI
OT  - inflammation
OT  - mortality
OT  - statin
EDAT- 2018/04/06 06:00
MHDA- 2019/08/07 06:00
CRDT- 2018/04/06 06:00
PHST- 2018/04/06 06:00 [pubmed]
PHST- 2019/08/07 06:00 [medline]
PHST- 2018/04/06 06:00 [entrez]
AID - 10.1080/1354750X.2018.1460765 [doi]
PST - ppublish
SO  - Biomarkers. 2019 Feb;24(1):17-22. doi: 10.1080/1354750X.2018.1460765. Epub 2018 
      Dec 9.