PMID- 29621183
OWN - NLM
STAT- MEDLINE
DCOM- 20180910
LR  - 20181114
IS  - 1422-0067 (Electronic)
IS  - 1422-0067 (Linking)
VI  - 19
IP  - 4
DP  - 2018 Apr 5
TI  - Tau-Induced Pathology in Epilepsy and Dementia: Notions from Patients and Animal 
      Models.
LID - 10.3390/ijms19041092 [doi]
LID - 1092
AB  - Patients with dementia present epilepsy more frequently than the general 
      population. Seizures are more common in patients with Alzheimer's disease (AD), 
      dementia with Lewy bodies (LBD), frontotemporal dementia (FTD) and progressive 
      supranuclear palsy (PSP) than in other dementias. Missense mutations in the 
      microtubule associated protein tau (MAPT) gene have been found to cause familial 
      FTD and PSP, while the P301S mutation in MAPT has been associated with 
      early-onset fast progressive dementia and the presence of seizures. Brains of 
      patients with AD, LBD, FTD and PSP show hyperphosphorylated tau aggregates, 
      amyloid-beta plaques and neuropil threads. Increasing evidence suggests the 
      existence of overlapping mechanisms related to the generation of network 
      hyperexcitability and cognitive decline. Neuronal overexpression of tau with 
      various mutations found in FTD with parkinsonism-linked to chromosome 17 
      (FTDP-17) in mice produces epileptic activity. On the other hand, the use of 
      certain antiepileptic drugs in animal models with AD prevents cognitive 
      impairment. Further efforts should be made to search for plausible common targets 
      for both conditions. Moreover, attempts should also be made to evaluate the use 
      of drugs targeting tau and amyloid-beta as suitable pharmacological interventions in 
      epileptic disorders. The diagnosis of dementia and epilepsy in early stages of 
      those diseases may be helpful for the initiation of treatments that could prevent 
      the generation of epileptic activity and cognitive deterioration.
FAU - Sanchez, Marina P
AU  - Sanchez MP
AUID- ORCID: 0000-0001-6785-7680
AD  - Laboratory of Neurology, IIS (Instituto Investigacion Sanitaria/Health Research 
      Institute)-Jimenez Diaz Foundation, UAM (Universidad Autonoma de 
      Madrid/Autonomous University of Madrid) and Biomedical Research Network Center on 
      Rare Diseases (CIBERER), 28045 Madrid, Spain. msanchezg@fjd.es.
FAU - Garcia-Cabrero, Ana M
AU  - Garcia-Cabrero AM
AD  - Laboratory of Neurology, IIS (Instituto Investigacion Sanitaria/Health Research 
      Institute)-Jimenez Diaz Foundation, UAM (Universidad Autonoma de 
      Madrid/Autonomous University of Madrid) and Biomedical Research Network Center on 
      Rare Diseases (CIBERER), 28045 Madrid, Spain. amgarcia@cnb.csic.es.
AD  - Department of Immunology and Oncology and Protein Tools Unit, Biotechnology 
      National Center (CNB/CSIC), 28049 Madrid, Spain. amgarcia@cnb.csic.es.
FAU - Sanchez-Elexpuru, Gentzane
AU  - Sanchez-Elexpuru G
AD  - Laboratory of Neurology, IIS (Instituto Investigacion Sanitaria/Health Research 
      Institute)-Jimenez Diaz Foundation, UAM (Universidad Autonoma de 
      Madrid/Autonomous University of Madrid) and Biomedical Research Network Center on 
      Rare Diseases (CIBERER), 28045 Madrid, Spain. gselexpuru@gmail.com.
FAU - Burgos, Daniel F
AU  - Burgos DF
AD  - Laboratory of Neurology, IIS (Instituto Investigacion Sanitaria/Health Research 
      Institute)-Jimenez Diaz Foundation, UAM (Universidad Autonoma de 
      Madrid/Autonomous University of Madrid) and Biomedical Research Network Center on 
      Rare Diseases (CIBERER), 28045 Madrid, Spain. daniel.fburgos@quironsalud.es.
FAU - Serratosa, Jose M
AU  - Serratosa JM
AD  - Laboratory of Neurology, IIS (Instituto Investigacion Sanitaria/Health Research 
      Institute)-Jimenez Diaz Foundation, UAM (Universidad Autonoma de 
      Madrid/Autonomous University of Madrid) and Biomedical Research Network Center on 
      Rare Diseases (CIBERER), 28045 Madrid, Spain. joseserratosa@me.com.
LA  - eng
GR  - P01 NS097197/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Review
DEP - 20180405
PL  - Switzerland
TA  - Int J Mol Sci
JT  - International journal of molecular sciences
JID - 101092791
RN  - 0 (tau Proteins)
SB  - IM
MH  - Animals
MH  - Brain/metabolism/pathology
MH  - Dementia/*metabolism/pathology
MH  - Epilepsy/*metabolism/pathology
MH  - Humans
MH  - tau Proteins/metabolism
PMC - PMC5979593
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - FTDP-17 mouse model
OT  - cognitive impairment
OT  - dementia
OT  - epilepsy
OT  - mouse models
OT  - neuronal excitability
OT  - seizures
OT  - tau
COIS- The authors declare no conflict of interest.
EDAT- 2018/04/06 06:00
MHDA- 2018/09/11 06:00
PMCR- 2018/04/01
CRDT- 2018/04/06 06:00
PHST- 2018/02/16 00:00 [received]
PHST- 2018/03/23 00:00 [revised]
PHST- 2018/04/03 00:00 [accepted]
PHST- 2018/04/06 06:00 [entrez]
PHST- 2018/04/06 06:00 [pubmed]
PHST- 2018/09/11 06:00 [medline]
PHST- 2018/04/01 00:00 [pmc-release]
AID - ijms19041092 [pii]
AID - ijms-19-01092 [pii]
AID - 10.3390/ijms19041092 [doi]
PST - epublish
SO  - Int J Mol Sci. 2018 Apr 5;19(4):1092. doi: 10.3390/ijms19041092.