PMID- 29621567
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20181211
IS  - 1618-0402 (Electronic)
IS  - 0940-9602 (Linking)
VI  - 219
DP  - 2018 Sep
TI  - Salivary biomarkers of inflammation in systemic lupus erythematosus.
PG  - 89-93
LID - S0940-9602(18)30034-7 [pii]
LID - 10.1016/j.aanat.2018.02.012 [doi]
AB  - Saliva is currently used as a reliable diagnostic fluid in a wide range of local 
      and systemic diseases. However, the link between salivary diagnosis and the 
      inflammatory process in autoimmune diseases has not yet been explored. The aim of 
      our study is to assess possible correlations between salivary inflammatory 
      markers and systemic lupus erythematosus (SLE). Patients fulfilling the Systemic 
      Lupus International Collaborating Clinics (SLICC) diagnosis criteria were 
      included. Salivary and serum levels of interleukin-6 (IL-6), leptin, monocyte 
      chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) 
      were determined using stochastic sensors. Serum leptin and IL-6 had significantly 
      higher levels in SLE patients compared to non-SLE. Also, salivary IL-6 levels 
      highly correlated with the serum IL-6 levels. A positive correlation was found 
      between salivary and serum levels of IL-6, signaling salivary IL-6 as a reliable 
      marker for assessing the inflammation process in SLE.
CI  - Copyright (c) 2018. Published by Elsevier GmbH.
FAU - Stanescu, Iulia-Ioana
AU  - Stanescu II
AD  - Carol Davila University of Medicine and Pharmacy Bucharest, 8 Eroii Sanitari 
      Blvd, 050474, Bucharest, Romania.
FAU - Calenic, Bogdan
AU  - Calenic B
AD  - Carol Davila University of Medicine and Pharmacy Bucharest, 8 Eroii Sanitari 
      Blvd, 050474, Bucharest, Romania. Electronic address: bogdan.calenic@umfcd.ro.
FAU - Dima, Alina
AU  - Dima A
AD  - Carol Davila University of Medicine and Pharmacy Bucharest, 8 Eroii Sanitari 
      Blvd, 050474, Bucharest, Romania.
FAU - Gugoasa, Livia Alexandra
AU  - Gugoasa LA
AD  - Laboratory of Electrochemistry and PATLAB, National Institute of Research for 
      Electrochemistry and Condensed Matter, 202 Splaiul Independentei, 060021, 
      Bucharest, Romania.
FAU - Balanescu, Eugenia
AU  - Balanescu E
AD  - Colentina Clinical Hospital, Colentina Research Center, 19-21 Stefan cel Mare 
      Street, 020125, Bucharest, Romania.
FAU - Stefan-van Staden, Raluca-Ioana
AU  - Stefan-van Staden RI
AD  - Laboratory of Electrochemistry and PATLAB, National Institute of Research for 
      Electrochemistry and Condensed Matter, 202 Splaiul Independentei, 060021, 
      Bucharest, Romania.
FAU - Baicus, Cristian
AU  - Baicus C
AD  - Carol Davila University of Medicine and Pharmacy Bucharest, 8 Eroii Sanitari 
      Blvd, 050474, Bucharest, Romania; Colentina Clinical Hospital, Colentina Research 
      Center, 19-21 Stefan cel Mare Street, 020125, Bucharest, Romania.
FAU - Badita, Daniela Gabriela
AU  - Badita DG
AD  - Carol Davila University of Medicine and Pharmacy Bucharest, 8 Eroii Sanitari 
      Blvd, 050474, Bucharest, Romania.
FAU - Greabu, Maria
AU  - Greabu M
AD  - Carol Davila University of Medicine and Pharmacy Bucharest, 8 Eroii Sanitari 
      Blvd, 050474, Bucharest, Romania.
LA  - eng
PT  - Journal Article
DEP - 20180403
PL  - Germany
TA  - Ann Anat
JT  - Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische 
      Gesellschaft
JID - 100963897
RN  - 0 (Biomarkers)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-6)
RN  - 0 (Leptin)
RN  - 0 (Plasminogen Activator Inhibitor 1)
SB  - IM
MH  - Adult
MH  - Biomarkers/analysis/blood
MH  - Case-Control Studies
MH  - Chemokine CCL2/*analysis/blood
MH  - Female
MH  - Humans
MH  - Inflammation/diagnosis
MH  - Interleukin-6/*analysis/blood
MH  - Leptin/*analysis/blood
MH  - Lupus Erythematosus, Systemic/blood/*diagnosis/metabolism
MH  - Middle Aged
MH  - Plasminogen Activator Inhibitor 1/*analysis/blood
MH  - Pregnancy
MH  - Pregnancy Complications/diagnosis/metabolism
MH  - Saliva/*chemistry
MH  - Serum/chemistry
OTO - NOTNLM
OT  - Biomarker
OT  - Interleukin-6
OT  - Leptin
OT  - Saliva
OT  - Systemic lupus erythematosus
EDAT- 2018/04/06 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/04/06 06:00
PHST- 2017/07/31 00:00 [received]
PHST- 2018/02/12 00:00 [revised]
PHST- 2018/02/22 00:00 [accepted]
PHST- 2018/04/06 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/04/06 06:00 [entrez]
AID - S0940-9602(18)30034-7 [pii]
AID - 10.1016/j.aanat.2018.02.012 [doi]
PST - ppublish
SO  - Ann Anat. 2018 Sep;219:89-93. doi: 10.1016/j.aanat.2018.02.012. Epub 2018 Apr 3.