PMID- 29621717
OWN - NLM
STAT- MEDLINE
DCOM- 20190110
LR  - 20190110
IS  - 1873-6750 (Electronic)
IS  - 0160-4120 (Linking)
VI  - 115
DP  - 2018 Jun
TI  - Circulating levels of perfluoroalkyl substances and left ventricular geometry of 
      the heart in the elderly.
PG  - 295-300
LID - S0160-4120(17)32060-3 [pii]
LID - 10.1016/j.envint.2018.03.033 [doi]
AB  - AIMS: Some persistent organic pollutants (POPs) such as hexachlorobenzene (HCB) 
      and some polychlorinated biphenyls (PCBs) have been shown to interfere with 
      myocardial function and geometry. We therefore investigated if also another group 
      of POPs: per- and polyfluoroalkyl substances (PFASs) were associated with 
      alterations in left ventricular geometry. METHODS: 801 subjects aged 70 years 
      were investigated in a cross-sectional study within the scope of the Prospective 
      Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Eight PFASs 
      were detected in >75% of participants  plasma by ultra-performance liquid 
      chromatograph/tandem mass spectrometry. Left ventricular geometry was determined 
      by echocardiography. Multivariable linear regression was used to investigate the 
      associations between PFASs and left ventricular geometry of the heart after 
      exclusion of subjects with previous myocardial infarction (n = 72). RESULTS: When 
      adjusting for multiple comparisons, none of the eight PFASs evaluated were 
      significantly related to left ventricular mass. However, perfluorononanoic acid 
      (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA) were 
      related to relative wall thickness (RWT) in a negative fashion (p < 0.0021). 
      Besides being inversely related to RWT, PFNA was also positively related to left 
      ventricular end-diastolic volume (LVEDD) (p < 0.0021). These analyses were 
      adjusted for traditional cardiovascular risk factors. CONCLUSION: In this 
      cross-sectional study, several of the PFASs evaluated, especially PFNA, were 
      related to myocardial geometry: a reduction in relative wall thickness and an 
      increase in left ventricular diameter following adjustment for traditional 
      cardiovascular risk factors, suggesting a role for PFASs in cardiac remodeling.
CI  - Copyright (c) 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Mobacke, Ingrid
AU  - Mobacke I
AD  - Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala 
      University, Uppsala, Sweden. Electronic address: i.mobacke@gmail.com.
FAU - Lind, Lars
AU  - Lind L
AD  - Department of Medical Sciences, Cardiovascular Epidemiology, Uppsala University, 
      Uppsala, Sweden. Electronic address: lars.lind@medsci.uu.se.
FAU - Dunder, Linda
AU  - Dunder L
AD  - Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala 
      University, Uppsala, Sweden. Electronic address: linda.dunder@medsci.uu.se.
FAU - Salihovic, Samira
AU  - Salihovic S
AD  - Department of Medical Sciences, Molecular Epidemiology and Science for Life 
      Laboratory, Uppsala University, Uppsala, Sweden. Electronic address: 
      samira.salihovic@medsci.uu.se.
FAU - Lind, P Monica
AU  - Lind PM
AD  - Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala 
      University, Uppsala, Sweden. Electronic address: monica.lind@medsci.uu.se.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180403
PL  - Netherlands
TA  - Environ Int
JT  - Environment international
JID - 7807270
RN  - 0 (Fluorocarbons)
SB  - IM
MH  - Aged
MH  - Cross-Sectional Studies
MH  - Echocardiography
MH  - Environmental Exposure
MH  - Fluorocarbons/*blood
MH  - Heart Ventricles/*diagnostic imaging
MH  - Humans
MH  - Prospective Studies
OTO - NOTNLM
OT  - Elderly
OT  - Environmental contaminants
OT  - Heart
OT  - Left ventricular geometry
OT  - Per- and polyfluoroalkyl substances (PFASs)
OT  - Perfluorononanoic acid (PFNA)
EDAT- 2018/04/06 06:00
MHDA- 2019/01/11 06:00
CRDT- 2018/04/06 06:00
PHST- 2017/12/01 00:00 [received]
PHST- 2018/03/02 00:00 [revised]
PHST- 2018/03/21 00:00 [accepted]
PHST- 2018/04/06 06:00 [pubmed]
PHST- 2019/01/11 06:00 [medline]
PHST- 2018/04/06 06:00 [entrez]
AID - S0160-4120(17)32060-3 [pii]
AID - 10.1016/j.envint.2018.03.033 [doi]
PST - ppublish
SO  - Environ Int. 2018 Jun;115:295-300. doi: 10.1016/j.envint.2018.03.033. Epub 2018 
      Apr 3.