PMID- 29621814
OWN - NLM
STAT- MEDLINE
DCOM- 20180914
LR  - 20221207
IS  - 1439-4286 (Electronic)
IS  - 0018-5043 (Linking)
VI  - 50
IP  - 4
DP  - 2018 Apr
TI  - A Meta-Analysis of the Associations Between the ATP-Binding Cassette Transporter 
      ABCA1 R219K (rs2230806) Polymorphism and the Risk of Type 2 Diabetes in Asians.
PG  - 308-316
LID - 10.1055/a-0583-0201 [doi]
AB  - Asians have relatively low insulin secretion capacity and readily develop type 2 
      diabetes mellitus (T2DM) when insulin resistant. For that reason, insufficient 
      insulin secretion is critical factor for Asians at the early stage of T2DM. 
      ATP-binding cassette transporter1 (ABCA1) is a membrane protein responsible for 
      cholesterol efflux and its function is also important for secreting insulin in 
      pancreatic beta-cells. Given the importance of its role, different polymorphisms of 
      ABCA1 gene might contribute differently to the development of T2DM. Here, we 
      analyzed the association between a variant form of ABCA1 gene called ABCA1 
      rs2230806 and the prevalence of T2DM in a large sample size by pooling all of the 
      case-control studies published. Relevant case-control studies were identified by 
      searching PubMed, EMBASE, Cochrane Library, Korean scientific database, Chinese 
      medical databases, and the Indian medical database. The association was evaluated 
      using five genetic models such as the allelic (AG), recessive (RG), dominant 
      (DG), homozygous (HMG), and heterozygous (HTG) genetic models. Heterogeneity of 
      each genetic model was determined by the I(2) test. A total of eight studies (7 
      published studies and one data set from the Korean Genetic Epidemiology Study) 
      were eligible, satisfying Hardy-Weinberg equilibrium and included 2755 T2DM 
      patients (case) and 16 635 nondiabetic subjects (control). All subjects in the 
      studies were Asians. Each genetic model exhibited heterogeneity. In all genetic 
      models, ABCA1 rs2230806 had a significant association with prevalence of T2DM: AG 
      (OR=0.78, 95% CI: 0.61-0.98), RG (OR=0.72, 95% CI: 0.51-1.03), DG (OR=0.73, 95% 
      CI: 0.55-0.97), HMG (OR=0.62, 95% CI: 0.41-0.96), and HTG (OR=0.78, 95% CI: 
      0.61-0.99). There was no single study that changed the overall effects in allelic 
      genetic model with random effects. No publication bias existed in any models 
      except the RG model. In conclusion, middle-aged and elderly adults with the minor 
      allele of ABCA1 rs2230806 will have a lower risk of T2DM. This is the first 
      meta-analysis to evaluate the association in Asians.
CI  - (c) Georg Thieme Verlag KG Stuttgart . New York.
FAU - Jung, Dongju
AU  - Jung D
AD  - Department of Biomedical Laboratory Science, Hoseo University, Asan, Chungnam, 
      Korea.
FAU - Cao, Shihua
AU  - Cao S
AD  - Department of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo 
      University, Asan, Chungnam, Korea.
FAU - Liu, Meiling
AU  - Liu M
AD  - Department of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo 
      University, Asan, Chungnam, Korea.
FAU - Park, Sunmin
AU  - Park S
AD  - Department of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo 
      University, Asan, Chungnam, Korea.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20180405
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (ABCA1 protein, human)
RN  - 0 (ATP Binding Cassette Transporter 1)
SB  - IM
EIN - Horm Metab Res. 2018 Apr;50(4):e4. PMID: 29879747
MH  - ATP Binding Cassette Transporter 1/*genetics
MH  - Asian People/*genetics
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/etiology/*genetics
MH  - *Genetic Predisposition to Disease
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
MH  - Prognosis
COIS- The authors declare that they have no conflict of interest.
EDAT- 2018/04/06 06:00
MHDA- 2018/09/15 06:00
CRDT- 2018/04/06 06:00
PHST- 2018/04/06 06:00 [entrez]
PHST- 2018/04/06 06:00 [pubmed]
PHST- 2018/09/15 06:00 [medline]
AID - 10.1055/a-0583-0201 [doi]
PST - ppublish
SO  - Horm Metab Res. 2018 Apr;50(4):308-316. doi: 10.1055/a-0583-0201. Epub 2018 Apr 
      5.