PMID- 29621884
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20190225
LR  - 20190225
IS  - 1559-4106 (Electronic)
IS  - 1559-4106 (Linking)
VI  - 13
IP  - 3
DP  - 2018 Apr 5
TI  - Plasma polymer film designs through the eyes of ToF-SIMS.
PG  - 03B417
LID - 10.1116/1.5016046 [doi]
AB  - Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is increasingly used 
      for the detailed chemical characterization of complex organic materials. Of 
      particular interest in biointerface materials, it provides the accurate molecular 
      information on their surface, a prerequisite for the understanding of subsequent 
      interaction with biomaterials. Plasma polymer films are promising biointerface 
      materials, as tuning the deposition parameters allows the control over film 
      stability and density of surface functional groups. However, the optimization of 
      these film properties not only requires a detailed characterization of the film 
      chemistry, but also that of the deposition mechanisms. Here, ToF-SIMS is used 
      within its different operation modes to investigate those on several plasma 
      polymer film designs. The detailed information on surface molecular chemistry, 
      interface conformation, vertical and lateral chemical and cross-linking gradients 
      is gathered and linked to the underlying deposition mechanisms. In combination 
      with other techniques, the interpretation and understanding of the final 
      functional property of the films in terms of protein adsorption and site-specific 
      binding is achieved.
FAU - Bernard, Laetitia
AU  - Bernard L
AD  - Laboratory for Nanoscale Materials Science, Empa, Uberlandstrasse 129, 8600 
      Dubendorf, Switzerland.
FAU - Rupper, Patrick
AU  - Rupper P
AD  - Laboratory for Advanced Fibers, Empa, Lerchenfeldstrasse 5, 9014 St. Gallen, 
      Switzerland.
FAU - Faccio, Greta
AU  - Faccio G
AD  - Laboratory for Biointerfaces, Empa, Lerchenfeldstrasse 5, 9014 St. Gallen, 
      Switzerland.
FAU - Hegemann, Dirk
AU  - Hegemann D
AD  - Laboratory for Advanced Fibers, Empa, Lerchenfeldstrasse 5, 9014 St. Gallen, 
      Switzerland.
FAU - Scholder, Olivier
AU  - Scholder O
AD  - Laboratory for Nanoscale Materials Science, Empa, Uberlandstrasse 129, 8600 
      Dubendorf, Switzerland.
FAU - Heuberger, Manfred
AU  - Heuberger M
AD  - Laboratory for Advanced Fibers, Empa, Lerchenfeldstrasse 5, 9014 St. Gallen, 
      Switzerland.
FAU - Maniura-Weber, Katharina
AU  - Maniura-Weber K
AD  - Laboratory for Biointerfaces, Empa, Lerchenfeldstrasse 5, 9014 St. Gallen, 
      Switzerland.
FAU - Vandenbossche, Marianne
AU  - Vandenbossche M
AD  - Laboratory for Advanced Fibers, Empa, Lerchenfeldstrasse 5, 9014 St. Gallen, 
      Switzerland.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180405
PL  - United States
TA  - Biointerphases
JT  - Biointerphases
JID - 101275679
EDAT- 2018/04/07 06:00
MHDA- 2018/04/07 06:01
CRDT- 2018/04/07 06:00
PHST- 2018/04/07 06:00 [entrez]
PHST- 2018/04/07 06:00 [pubmed]
PHST- 2018/04/07 06:01 [medline]
AID - 10.1116/1.5016046 [doi]
PST - epublish
SO  - Biointerphases. 2018 Apr 5;13(3):03B417. doi: 10.1116/1.5016046.