PMID- 29622820
OWN - NLM
STAT- MEDLINE
DCOM- 20180924
LR  - 20220408
IS  - 2616-163X (Electronic)
IS  - 0016-9560 (Print)
IS  - 0016-9560 (Linking)
VI  - 51
IP  - 3
DP  - 2017 Sep
TI  - High risk of coagulopathy among Type-2 Diabetes Mellitus clients at a municipal 
      hospital in Ghana.
PG  - 101-107
AB  - BACKGROUND: Persistent hyperglycaemia in diabetes mellitus causes coagulopathies 
      due to glycation of haemoglobin, prothrombin, fibrinogen and other proteins 
      involved in the clotting mechanism. Shortened activated partial thromboplastin 
      time (APTT) and prothrombin time (PT) reflect hypercoagulable state, which is 
      associated with an increased thrombotic risk and adverse cardiovascular effects. 
      This study assessed the coagulation profile of type 2 diabetes mellitus (T2DM) 
      clients at a municipal hospital in Ghana. METHODS: A hospital-based case-control 
      study was conducted from January to April 2015 at the Agona Swedru Municipal 
      Hospital. Sixty (60) persons with T2DM and 40 without were recruited and screened 
      using appropriate protocols. Blood samples were collected for coagulation and 
      biochemical tests. Demographic and clinical information were collected using 
      pre-tested questionnaire. Data was analyzed with GraphPad Prism version 5. 
      RESULTS: APTT and PT were significantly shorter among patients with T2DM compared 
      to those without (20.88 +/- 5.19 v 31.23 +/- 5.41, P=0.0001; and 11.03 +/- 2.06sec v 
      14.46 +/- 1.86, P=0.0001 respectively). INR was decreased among patients with T2DM 
      compared to those without (0.83 +/- 0.18 v 1.13 +/- 0.17, P=0.0001). No significant 
      difference was found in platelet count between T2DM and non-diabetics (179.85 +/- 
      66.15x10(3) /mm(3) v 168.55 +/- 35.77x10(3) /mm(3), P=0.326). Serum magnesium was 
      lower among the T2DM patients compared to the non-diabetics, while serum ionized 
      calcium was significantly higher among the T2DM patients (P<0.05). CONCLUSION: 
      Clients with T2DM may have a high coagulation risk evidenced by shortened APTT, 
      PT and a high ionized calcium compared with controls. FUNDING: Study was funded 
      by Lord Ampomah and Solomon Panford.
FAU - Ephraim, Richard Kd
AU  - Ephraim RK
AD  - Department of Medical Laboratory Science, School of Allied Health Sciences, 
      University of Cape Coast, Cape Coast.
FAU - Awuku, Yaw A
AU  - Awuku YA
AD  - Department of Internal Medicine and Therapeutics, University of Cape Coast, Cape 
      Coast.
FAU - Adu, Patrick
AU  - Adu P
AD  - Department of Medical Laboratory Science, School of Allied Health Sciences, 
      University of Cape Coast, Cape Coast.
FAU - Ampomah, Lord Tw
AU  - Ampomah LT
AD  - Department of Medical Laboratory Science, School of Allied Health Sciences, 
      University of Cape Coast, Cape Coast.
FAU - Adoba, Prince
AU  - Adoba P
AD  - Department of Molecular Medicine, School of Medical Sciences, College of Health 
      Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
FAU - Panford, Solomon
AU  - Panford S
AD  - Department of Medical Laboratory Science, School of Allied Health Sciences, 
      University of Cape Coast, Cape Coast.
FAU - Ninnoni, Jerry Pk
AU  - Ninnoni JP
AD  - Department of Mental Health, School of Nursing, University of Cape Coast, Cape 
      Coast, Ghana.
FAU - Agbodzakey, Hope
AU  - Agbodzakey H
AD  - Department of Medical Laboratory Science, School of Allied Health Sciences, 
      University of Cape Coast, Cape Coast.
AD  - Department of Internal Medicine and Therapeutics, University of Cape Coast, Cape 
      Coast.
AD  - Department of Molecular Medicine, School of Medical Sciences, College of Health 
      Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
AD  - Department of Mental Health, School of Nursing, University of Cape Coast, Cape 
      Coast, Ghana.
LA  - eng
PT  - Journal Article
PL  - Ghana
TA  - Ghana Med J
JT  - Ghana medical journal
JID - 0073210
RN  - I38ZP9992A (Magnesium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Blood Coagulation Disorders/epidemiology/*physiopathology
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*blood/complications
MH  - Female
MH  - Ghana/epidemiology
MH  - Hospitals, Municipal
MH  - Humans
MH  - Logistic Models
MH  - Magnesium/blood
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Partial Thromboplastin Time
MH  - Platelet Count
MH  - Prothrombin Time
PMC - PMC5870234
OTO - NOTNLM
OT  - Type 2 Diabetes Mellitus
OT  - activated partial thromboplastin time
OT  - coagulation, prothrombin time
OT  - ionized Calcium
COIS- Conflict of interest: None declared
EDAT- 2018/04/07 06:00
MHDA- 2018/09/25 06:00
PMCR- 2017/09/01
CRDT- 2018/04/07 06:00
PHST- 2018/04/07 06:00 [entrez]
PHST- 2018/04/07 06:00 [pubmed]
PHST- 2018/09/25 06:00 [medline]
PHST- 2017/09/01 00:00 [pmc-release]
AID - jGMJ.v51.i3.pg101 [pii]
AID - 10.4314/gmj.v51i3.2 [doi]
PST - ppublish
SO  - Ghana Med J. 2017 Sep;51(3):101-107. doi: 10.4314/gmj.v51i3.2.