PMID- 29623390
OWN - NLM
STAT- MEDLINE
DCOM- 20181211
LR  - 20220331
IS  - 1437-160X (Electronic)
IS  - 0172-8172 (Linking)
VI  - 38
IP  - 8
DP  - 2018 Aug
TI  - The role of genetics and epigenetics in rheumatic diseases: are they really a 
      target to be aimed at?
PG  - 1333-1338
LID - 10.1007/s00296-018-4026-0 [doi]
AB  - To date, numerous genetic and epigenetic studies have been performed and provided 
      a crucial step forward in our understanding of the pathogenesis of rheumatic 
      diseases. However, most of the recent advances in the treatment of rheumatic 
      diseases including biological therapies are not based on or even discrepant from 
      these genetic and epigenetic findings. For example, tumor necrosis factor 
      inhibitors are quite successful in the treatment of rheumatoid arthritis (RA), 
      Behcet's disease (BD), ankylosing spondylitis (AS) and psoriatic arthritis (PsA) 
      but not in that of systemic lupus erythematosus (SLE), systemic sclerosis (SSc), 
      Sjogren's syndrome (SS) and antineutrophil cytoplasmic antibody-associated 
      vasculitis (AAV), conversely, RA shares genetic backgrounds more with SLE, SSc, 
      SS and AAV than BD, AS and PsA. In this review, we briefly highlight the findings 
      from recent genetic and epigenetic studies and discuss what needs to be studied 
      to provide a novel, more efficacious management of rheumatic diseases.
FAU - Kato, Masaru
AU  - Kato M
AUID- ORCID: 0000-0002-2023-6585
AD  - Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and 
      Graduate School of Medicine, Hokkaido University, N15W7, Kita-Ku, Sapporo, 
      060-8638, Japan. ktmasaru@med.hokudai.ac.jp.
FAU - Yasuda, Shinsuke
AU  - Yasuda S
AUID- ORCID: 0000-0001-6171-2077
AD  - Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and 
      Graduate School of Medicine, Hokkaido University, N15W7, Kita-Ku, Sapporo, 
      060-8638, Japan.
FAU - Atsumi, Tatsuya
AU  - Atsumi T
AUID- ORCID: 0000-0001-5657-962X
AD  - Department of Rheumatology, Endocrinology and Nephrology, Faculty of Medicine and 
      Graduate School of Medicine, Hokkaido University, N15W7, Kita-Ku, Sapporo, 
      060-8638, Japan.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20180405
PL  - Germany
TA  - Rheumatol Int
JT  - Rheumatology international
JID - 8206885
RN  - 0 (Antirheumatic Agents)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Antirheumatic Agents/*therapeutic use
MH  - Arthritis, Psoriatic/genetics/therapy
MH  - Arthritis, Rheumatoid/genetics/therapy
MH  - Humans
MH  - Lupus Erythematosus, Systemic/genetics/therapy
MH  - Receptors, Tumor Necrosis Factor/administration & dosage
MH  - Rheumatic Diseases/*genetics/*therapy
MH  - Spondylitis, Ankylosing/genetics/therapy
MH  - Tumor Necrosis Factor-alpha/antagonists & inhibitors
OTO - NOTNLM
OT  - Epigenetics
OT  - GWAS
OT  - Genetics
OT  - Rheumatic diseases
EDAT- 2018/04/07 06:00
MHDA- 2018/12/12 06:00
CRDT- 2018/04/07 06:00
PHST- 2018/02/12 00:00 [received]
PHST- 2018/04/03 00:00 [accepted]
PHST- 2018/04/07 06:00 [pubmed]
PHST- 2018/12/12 06:00 [medline]
PHST- 2018/04/07 06:00 [entrez]
AID - 10.1007/s00296-018-4026-0 [pii]
AID - 10.1007/s00296-018-4026-0 [doi]
PST - ppublish
SO  - Rheumatol Int. 2018 Aug;38(8):1333-1338. doi: 10.1007/s00296-018-4026-0. Epub 
      2018 Apr 5.