PMID- 29623614
OWN - NLM
STAT- MEDLINE
DCOM- 20181003
LR  - 20200930
IS  - 1573-3017 (Electronic)
IS  - 0963-9292 (Linking)
VI  - 27
IP  - 5
DP  - 2018 Jul
TI  - Effects of halogenated contaminants on reproductive development in wild mink 
      (Neovison vison) from locations in Canada.
PG  - 539-555
LID - 10.1007/s10646-018-1926-4 [doi]
AB  - The concept of the Anthropocene, that humans are now re-engineering global 
      ecosystems, is in part evidenced by the pervasive pollution by persistent organic 
      pollutants (POPs). Certain POPs are hormone mimics and can disrupt endocrine and 
      hence reproductive processes, shown mainly by laboratory studies with model 
      species. There are, in contrast, fewer confirmations of such disruption from 
      eco-epidemiological studies of wild mammals. Here we used the American mink 
      (Neovison vison) as a sentinel species for such a study. Over the period 
      1998-2006, 161 mink carcasses were obtained from commercial trappers in the 
      Canadian provinces of British Columbia and Ontario. Mink were aged, sexed, 
      measured, and body condition assessed. Livers were analyzed either individually 
      or pooled for organochlorine (OC) pesticides, polychlorinated biphenyls (PCBs), 
      and subsets for polybrominated diphenyl ethers (PBDEs). We primarily addressed 
      whether contaminants affected male reproductive development by measuring baculum 
      size and assessing the influences of age and body condition. We also considered 
      the influence of spatial variation on relative exposure and size of baculum. 
      Statistical models separated by age class revealed that significant relationships 
      between baculum length or mass and juvenile mink were mostly positive, whereas 
      for adults and first year mink they were mostly negative. A significant negative 
      relationship for adult mink was determined between DDE and both baculum length 
      and mass. For juvenile mink we found significant positive relationships between 
       summation operatorPCBs, DDE and  summation operatorPBDEs with baculum length. Our results provide some indication of 
      negative effects of halogenated contaminants on male reproductive development in 
      wild mink, and the most likely candidate chemical is the confirmed 
      anti-androgenic compound, DDE, rather than PCBs or other compounds.
FAU - Elliott, John E
AU  - Elliott JE
AUID- ORCID: 0000-0001-5820-1225
AD  - Environment and Climate Change Canada, Ecotoxicology and Wildlife Health 
      Division, Delta, BC, Canada. john.elliott@canada.ca.
FAU - Kirk, David Anthony
AU  - Kirk DA
AD  - Aquila Conservation & Environment Consulting, 75 Albert Street, Ottawa, ON, 
      Canada.
FAU - Martin, Pamela A
AU  - Martin PA
AD  - Environment and Climate Change Canada, Ecotoxicology and Wildlife Health 
      Division, Burlington, ON, Canada.
FAU - Wilson, Laurie K
AU  - Wilson LK
AD  - Environment and Climate Change Canada, Canadian Wildlife Service, Delta, BC, 
      Canada.
FAU - Kardosi, Gabriela
AU  - Kardosi G
AD  - Environment and Climate Change Canada, Canadian Wildlife Service, Delta, BC, 
      Canada.
FAU - Lee, Sandi
AU  - Lee S
AD  - Environment and Climate Change Canada, Ecotoxicology and Wildlife Health 
      Division, Delta, BC, Canada.
FAU - McDaniel, Tana
AU  - McDaniel T
AD  - Environment and Climate Change Canada, Ecotoxicology and Wildlife Health 
      Division, Burlington, ON, Canada.
FAU - Hughes, Kimberley D
AU  - Hughes KD
AD  - Broadwing Biological Consulting, 1944 Parkside Drive, Pickering, ON, Canada.
FAU - Smith, Barry D
AU  - Smith BD
AD  - Environment and Climate Change Canada, Canadian Wildlife Service, Delta, BC, 
      Canada.
FAU - Idrissi, Abde Miftah
AU  - Idrissi AM
AD  - Environment and Climate Change Canada, Ecotoxicology and Wildlife Health 
      Division, Ottawa, ON, Canada.
LA  - eng
PT  - Journal Article
DEP - 20180406
PL  - United States
TA  - Ecotoxicology
JT  - Ecotoxicology (London, England)
JID - 9885956
RN  - 0 (Environmental Pollutants)
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
SB  - IM
MH  - Age Factors
MH  - Animals
MH  - Body Composition/drug effects
MH  - British Columbia
MH  - *Environmental Exposure
MH  - Environmental Monitoring
MH  - Environmental Pollutants/*adverse effects
MH  - Halogenated Diphenyl Ethers/adverse effects
MH  - Hydrocarbons, Chlorinated/adverse effects
MH  - Male
MH  - Mink/*metabolism
MH  - Ontario
MH  - Organ Size/drug effects
MH  - Pesticides/adverse effects
MH  - Polychlorinated Biphenyls/adverse effects
MH  - Reproduction/*drug effects
OTO - NOTNLM
OT  - Baculum
OT  - DDE
OT  - Endocrine disruption
OT  - Mink Neovison vison
OT  - POPs
OT  - Reproduction
EDAT- 2018/04/07 06:00
MHDA- 2018/10/04 06:00
CRDT- 2018/04/07 06:00
PHST- 2018/03/03 00:00 [accepted]
PHST- 2018/04/07 06:00 [pubmed]
PHST- 2018/10/04 06:00 [medline]
PHST- 2018/04/07 06:00 [entrez]
AID - 10.1007/s10646-018-1926-4 [pii]
AID - 10.1007/s10646-018-1926-4 [doi]
PST - ppublish
SO  - Ecotoxicology. 2018 Jul;27(5):539-555. doi: 10.1007/s10646-018-1926-4. Epub 2018 
      Apr 6.