PMID- 29625486
OWN - NLM
STAT- MEDLINE
DCOM- 20180821
LR  - 20180821
IS  - 1552-5783 (Electronic)
IS  - 0146-0404 (Linking)
VI  - 59
IP  - 3
DP  - 2018 Mar 1
TI  - Structure-Function Analysis in Patients With Intermediate Age-Related Macular 
      Degeneration.
PG  - 1599-1608
LID - 10.1167/iovs.17-22712 [doi]
AB  - PURPOSE: To examine the topographic correlation between retinal morphology and 
      retinal sensitivity by mesopic and scotopic fundus-controlled perimetry (FCP) in 
      eyes with intermediate AMD. METHODS: Thirty-five eyes from 32 patients (mean age 
      70.9 years) and 29 age-matched controls prospectively underwent spectral-domain 
      optical coherence tomography (SD-OCT) imaging. Mesopic (Goldman III, 200 ms, 4-2 
      strategy) and scotopic (Goldman V, 200 ms, 4-2 strategy) FCP with a 56-stimulus 
      point grid was performed in AMD patients with the MP-1S. Thickness values of 
      different retinal layers were measured at each stimulus point and compared, 
      topographically corresponding to values in controls of similar age for pointwise 
      structural-functional analysis. RESULTS: The overall mean sensitivity in patients 
      was 16.9 +/- 3.0 dB for mesopic and 14.0 +/- 3.7 dB for scotopic testing. Within the 
      central 4 degrees  of the macula, reduced mesopic and scotopic sensitivity values were 
      found (P < 0.0001). These findings correlated to central increasing retinal 
      pigment epithelium-drusen complex (RPEDC) thickness and central decreasing outer 
      nuclear layer (ONL) and photoreceptor (PR)-segments thickness (P < 0.0001, 
      respectively). Structure-function correlations revealed that a reduction of 
      mesopic and scotopic sensitivity was associated with increasing thickness of the 
      total retina and the RPEDC and a decrease of the ONL and the PR-segments (P < 
      0.001, respectively). CONCLUSIONS: Accumulation of sub-RPE material in patients 
      with intermediate AMD is spatially associated to quantifiable structural 
      alterations in various retinal layers and to corresponding retinal dysfunction. 
      The topographic analysis of retinal thickness and retinal sensitivity will be 
      helpful for a better understanding of the disease process and for the evaluation 
      of new interventional approaches.
FAU - Sassmannshausen, Marlene
AU  - Sassmannshausen M
AD  - Department of Ophthalmology, University of Bonn, Bonn, Germany.
FAU - Steinberg, Julia S
AU  - Steinberg JS
AD  - Department of Ophthalmology, University of Bonn, Bonn, Germany.
FAU - Fimmers, Rolf
AU  - Fimmers R
AD  - Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, 
      Medical Faculty, Bonn, Germany.
FAU - Pfau, Maximilian
AU  - Pfau M
AD  - Department of Ophthalmology, University of Bonn, Bonn, Germany.
FAU - Thiele, Sarah
AU  - Thiele S
AD  - Department of Ophthalmology, University of Bonn, Bonn, Germany.
FAU - Fleckenstein, Monika
AU  - Fleckenstein M
AD  - Department of Ophthalmology, University of Bonn, Bonn, Germany.
FAU - Holz, Frank G
AU  - Holz FG
AD  - Department of Ophthalmology, University of Bonn, Bonn, Germany.
FAU - Schmitz-Valckenberg, Steffen
AU  - Schmitz-Valckenberg S
AD  - Department of Ophthalmology, University of Bonn, Bonn, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Invest Ophthalmol Vis Sci
JT  - Investigative ophthalmology & visual science
JID - 7703701
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Macular Degeneration/*physiopathology
MH  - Male
MH  - Mesopic Vision/physiology
MH  - Middle Aged
MH  - Night Vision/physiology
MH  - Retina/*physiopathology
MH  - Retinal Pigment Epithelium/physiopathology
MH  - Tomography, Optical Coherence/methods
EDAT- 2018/04/07 06:00
MHDA- 2018/08/22 06:00
CRDT- 2018/04/07 06:00
PHST- 2018/04/07 06:00 [entrez]
PHST- 2018/04/07 06:00 [pubmed]
PHST- 2018/08/22 06:00 [medline]
AID - 2676355 [pii]
AID - 10.1167/iovs.17-22712 [doi]
PST - ppublish
SO  - Invest Ophthalmol Vis Sci. 2018 Mar 1;59(3):1599-1608. doi: 
      10.1167/iovs.17-22712.