PMID- 29625591
OWN - NLM
STAT- MEDLINE
DCOM- 20180917
LR  - 20181114
IS  - 1756-0500 (Electronic)
IS  - 1756-0500 (Linking)
VI  - 11
IP  - 1
DP  - 2018 Apr 6
TI  - Neurodevelopmental assessment of HIV-exposed uninfected and early-treated 
      HIV-infected children: study protocol.
PG  - 235
LID - 10.1186/s13104-018-3331-8 [doi]
LID - 235
AB  - OBJECTIVE: Sub-Saharan Africa has the highest prevalence of children at risk of 
      not achieving their developmental potential, attributable largely to the human 
      immunodeficiency virus (HIV) pandemic coupled with negative environmental 
      factors. Childhood developmental stimulation programmes can mitigate adverse 
      outcomes. METHODS: Neonates testing HIV positive at birth will be initiated on 
      antiretroviral treatment (ART) and receive an age-appropriate stimulation 
      program, updated at 3 monthly intervals through the first year of life. 
      Neurodevelopment at 12 months of age will be assessed using the Bayley Scales of 
      Infant and Toddler Development, Third Edition (BSID-III). Outcomes will be 
      compared with HIV-infected and HIV-exposed uninfected children (HEU) not having 
      received the stimulatory intervention. Associations between neurodevelopmental 
      outcomes, environmental factors, and parental stress will be investigated. The 
      study will take place at a single site in Johannesburg, South Africa. This 
      non-randomised controlled intervention study, with a single non-blinded 
      comparative intervention group, aims to investigate whether an early childhood 
      stimulation programme used in conjunction with ART initiated at birth can 
      positively impact neurodevelopmental outcomes at 1 year of age in children 
      infected with HIV. Trial registration 15 January 2018, Pan African Clinical Trial 
      Registry PACTR201801002967587.
FAU - Strehlau, Renate
AU  - Strehlau R
AUID- ORCID: 0000-0001-9113-6584
AD  - Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, 
      Department of Paediatrics and Child Health, Faculty of Health Sciences, 
      University of the Witwatersrand, Johannesburg, South Africa. 
      renate.strehlau@wits.ac.za.
FAU - van Aswegen, Tamryn
AU  - van Aswegen T
AD  - Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, 
      Department of Paediatrics and Child Health, Faculty of Health Sciences, 
      University of the Witwatersrand, Johannesburg, South Africa.
FAU - Potterton, Joanne
AU  - Potterton J
AD  - Empilweni Services and Research Unit, Rahima Moosa Mother and Child Hospital, 
      Department of Paediatrics and Child Health, Faculty of Health Sciences, 
      University of the Witwatersrand, Johannesburg, South Africa.
AD  - Department of Physiotherapy, School of Therapeutic Sciences, Faculty of Health 
      Sciences, University of the Witwatersrand, Johannesburg, South Africa.
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
DEP - 20180406
PL  - England
TA  - BMC Res Notes
JT  - BMC research notes
JID - 101462768
RN  - 0 (Anti-HIV Agents)
SB  - IM
MH  - Anti-HIV Agents/administration & dosage/*pharmacology
MH  - Child Development/*physiology
MH  - Clinical Protocols
MH  - Early Medical Intervention/*methods
MH  - Female
MH  - Follow-Up Studies
MH  - HIV Infections/*drug therapy
MH  - HIV Seropositivity/drug therapy
MH  - Humans
MH  - Infant
MH  - Infant, Newborn
MH  - Male
MH  - Pregnancy
MH  - *Pregnancy Complications, Infectious
MH  - Prenatal Exposure Delayed Effects/*diagnosis/prevention & control
MH  - South Africa
PMC - PMC5889550
OTO - NOTNLM
OT  - Early antiretroviral treatment
OT  - Early childhood development
OT  - HIV
EDAT- 2018/04/08 06:00
MHDA- 2018/09/18 06:00
PMCR- 2018/04/06
CRDT- 2018/04/08 06:00
PHST- 2018/01/09 00:00 [received]
PHST- 2018/03/26 00:00 [accepted]
PHST- 2018/04/08 06:00 [entrez]
PHST- 2018/04/08 06:00 [pubmed]
PHST- 2018/09/18 06:00 [medline]
PHST- 2018/04/06 00:00 [pmc-release]
AID - 10.1186/s13104-018-3331-8 [pii]
AID - 3331 [pii]
AID - 10.1186/s13104-018-3331-8 [doi]
PST - epublish
SO  - BMC Res Notes. 2018 Apr 6;11(1):235. doi: 10.1186/s13104-018-3331-8.