PMID- 29626215
OWN - NLM
STAT- MEDLINE
DCOM- 20190819
LR  - 20200306
IS  - 1471-0080 (Electronic)
IS  - 1471-0072 (Print)
IS  - 1471-0072 (Linking)
VI  - 19
IP  - 6
DP  - 2018 Jun
TI  - The coming of age of chaperone-mediated autophagy.
PG  - 365-381
LID - 10.1038/s41580-018-0001-6 [doi]
AB  - Chaperone-mediated autophagy (CMA) was the first studied process that indicated 
      that degradation of intracellular components by the lysosome can be selective - a 
      concept that is now well accepted for other forms of autophagy. Lysosomes can 
      degrade cellular cytosol in a nonspecific manner but can also discriminate what 
      to target for degradation with the involvement of a degradation tag, a chaperone 
      and a sophisticated mechanism to make the selected proteins cross the lysosomal 
      membrane through a dedicated translocation complex. Recent studies modulating CMA 
      activity in vivo using transgenic mouse models have demonstrated that selectivity 
      confers on CMA the ability to participate in the regulation of multiple cellular 
      functions. Timely degradation of specific cellular proteins by CMA modulates, for 
      example, glucose and lipid metabolism, DNA repair, cellular reprograming and the 
      cellular response to stress. These findings expand the physiological relevance of 
      CMA beyond its originally identified role in protein quality control and reveal 
      that CMA failure with age may aggravate diseases, such as ageing-associated 
      neurodegeneration and cancer.
FAU - Kaushik, Susmita
AU  - Kaushik S
AD  - Department of Developmental and Molecular Biology, Albert Einstein College of 
      Medicine, Bronx, NY, USA. susmita.kaushik@einstein.yu.edu.
AD  - Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA. 
      susmita.kaushik@einstein.yu.edu.
FAU - Cuervo, Ana Maria
AU  - Cuervo AM
AUID- ORCID: 0000-0002-0771-700X
AD  - Department of Developmental and Molecular Biology, Albert Einstein College of 
      Medicine, Bronx, NY, USA. ana-maria.cuervo@einstein.yu.edu.
AD  - Institute for Aging Studies, Albert Einstein College of Medicine, Bronx, NY, USA. 
      ana-maria.cuervo@einstein.yu.edu.
LA  - eng
GR  - U54 NS100717/NS/NINDS NIH HHS/United States
GR  - R01 AG021904/AG/NIA NIH HHS/United States
GR  - P30 DK041296/DK/NIDDK NIH HHS/United States
GR  - R37 AG021904/AG/NIA NIH HHS/United States
GR  - RF1 AG054108/AG/NIA NIH HHS/United States
GR  - R01 DK098408/DK/NIDDK NIH HHS/United States
GR  - P01 AG031782/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Review
PL  - England
TA  - Nat Rev Mol Cell Biol
JT  - Nature reviews. Molecular cell biology
JID - 100962782
RN  - 0 (Molecular Chaperones)
MH  - Animals
MH  - Autophagy/*physiology
MH  - Humans
MH  - Lysosomes/metabolism/physiology
MH  - Molecular Chaperones/*metabolism
MH  - Neoplasms/metabolism/pathology
MH  - Neurodegenerative Diseases/metabolism/pathology
PMC - PMC6399518
MID - NIHMS1008550
COIS- Competing interests The authors declare no competing interests.
EDAT- 2018/04/08 06:00
MHDA- 2019/08/20 06:00
PMCR- 2019/06/01
CRDT- 2018/04/08 06:00
PHST- 2018/04/08 06:00 [pubmed]
PHST- 2019/08/20 06:00 [medline]
PHST- 2018/04/08 06:00 [entrez]
PHST- 2019/06/01 00:00 [pmc-release]
AID - 10.1038/s41580-018-0001-6 [pii]
AID - 10.1038/s41580-018-0001-6 [doi]
PST - ppublish
SO  - Nat Rev Mol Cell Biol. 2018 Jun;19(6):365-381. doi: 10.1038/s41580-018-0001-6.