PMID- 29626513
OWN - NLM
STAT- MEDLINE
DCOM- 20180604
LR  - 20180604
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 662
DP  - 2018 Jul 1
TI  - Effects of exercise training on adipose tissue apelin expression in 
      streptozotocin-nicotinamide induced diabetic rats.
PG  - 97-102
LID - S0378-1119(18)30364-0 [pii]
LID - 10.1016/j.gene.2018.04.003 [doi]
AB  - Apelin is an adipocyte-derived peptide that plays an important role in regulation 
      of energy homoeostasis and decrease of insulin resistance. We investigated the 
      effects of exercise training on adipose tissue apelin expression in 
      streptozotocin-nicotinamide induced diabetic rats. In this experimental study, 38 
      male Wistar rats were assigned to 4 groups: sedentary non-diabetic, trained 
      non-diabetic, sedentary diabetic and trained diabetic. Type 2 diabetes mellitus 
      (T2DM) was induced by intraperitoneal injection of streptozotocin and 
      nicotinamide in adult rats. The trained groups ran 8-week on treadmill 
      progressively for 45 min at a speed of 24 m/min and a 5% grade. After the 
      training period, an intraperitoneal glucose tolerance test was performed in 
      addition to the measurement of blood lipids and plasma apelin levels. Apelin mRNA 
      levels in visceral adipose tissue were also analyzed. Two-way repeated measures 
      analysis of variance (ANOVA) and Pearson correlation coefficient was used for 
      analyzing data. P < 0.05 was considered to be statistically significant. Results 
      indicated a significant decrease of insulin resistance followed by a significant 
      increase of plasma levels and mRNA expression of apelin in trained diabetic 
      compared with sedentary diabetic rats. Furthermore, apelin levels did not 
      correlate significantly with body weight and epididymal fat weight in trained 
      diabetic rats. In conclusion, the findings revealed that chronic exercise 
      training, independently of body weight and fat pad weight by decrease of insulin 
      resistance can increase apelin levels in visceral adipose tissue, thereby 
      attenuating the progression of diabetes and decreasing insulin resistance in T2DM 
      rats.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Kazemi, Fahimeh
AU  - Kazemi F
AD  - Department of Exercise Physiology, Faculty of Physical Education and Sport 
      Sciences, Alzahra University, Tehran, Iran. Electronic address: 
      f.kazemi@alzahra.ac.ir.
FAU - Zahediasl, Saleh
AU  - Zahediasl S
AD  - Endocrine Physiology Research Center, Research Institute for Endocrine Sciences, 
      Shahid Beheshti University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20180405
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (Apelin)
RN  - 0 (Apln protein, rat)
RN  - 0 (Blood Glucose)
RN  - 0 (Insulin)
RN  - 25X51I8RD4 (Niacinamide)
RN  - 5W494URQ81 (Streptozocin)
SB  - IM
MH  - Adipose Tissue/physiology
MH  - Animals
MH  - Apelin/*genetics/*metabolism
MH  - Blood Glucose/metabolism
MH  - Body Weight
MH  - Diabetes Mellitus, Experimental/metabolism
MH  - Diabetes Mellitus, Type 2/metabolism
MH  - Disease Models, Animal
MH  - Glucose Tolerance Test
MH  - Insulin/metabolism
MH  - Insulin Resistance/physiology
MH  - Intra-Abdominal Fat/metabolism
MH  - Male
MH  - Motor Activity/*physiology
MH  - Niacinamide/pharmacology
MH  - Obesity/metabolism
MH  - Physical Conditioning, Animal/methods
MH  - Rats
MH  - Rats, Wistar
MH  - Streptozocin/pharmacology
MH  - Transcriptome
OTO - NOTNLM
OT  - Adipokine
OT  - Aerobic exercise
OT  - Apelin
OT  - Type 2 diabetes
OT  - Visceral adipose tissue
EDAT- 2018/04/08 06:00
MHDA- 2018/06/05 06:00
CRDT- 2018/04/08 06:00
PHST- 2018/02/09 00:00 [received]
PHST- 2018/03/28 00:00 [revised]
PHST- 2018/04/03 00:00 [accepted]
PHST- 2018/04/08 06:00 [pubmed]
PHST- 2018/06/05 06:00 [medline]
PHST- 2018/04/08 06:00 [entrez]
AID - S0378-1119(18)30364-0 [pii]
AID - 10.1016/j.gene.2018.04.003 [doi]
PST - ppublish
SO  - Gene. 2018 Jul 1;662:97-102. doi: 10.1016/j.gene.2018.04.003. Epub 2018 Apr 5.