PMID- 29627429
OWN - NLM
STAT- MEDLINE
DCOM- 20181102
LR  - 20181102
IS  - 1873-1708 (Electronic)
IS  - 0890-6238 (Linking)
VI  - 78
DP  - 2018 Jun
TI  - Gestational exposure to tetrabutyltin blocks rat fetal Leydig cell development.
PG  - 111-119
LID - S0890-6238(17)30648-2 [pii]
LID - 10.1016/j.reprotox.2018.04.001 [doi]
AB  - Tetrabutyltin is a stable organotin and may exhibit endocrine disrupting 
      properties. Herein, we investigated effects of tetrabutyltin on the development 
      of rat fetal Leydig cells, which support differentiation of the male reproductive 
      tract in late gestation. Female pregnant Sprague Dawley rats were gavaged with 
      tetrabutyltin (0, 100, 200, and 500 mg/kg) from gestational day (GD) 12 to GD 21. 
      Tetrabutyltin dose-dependently decreased testicular testosterone levels 
      (0.756 +/- 0.208 and 0.813 +/- 0.277 ng/testis at the 200 and 500 mg/kg doses, 
      respectively) compared to control (1.692 +/- 0.218 ng/testis) at GD 21. 
      Furthermore, tetrabutyltin induced fetal Leydig cell aggregation, decreased fetal 
      Leydig cell size and cytoplasmic size at the >/=100 mg/kg doses, and downregulated 
      the expression levels of Scarb1, Cyp17a1, and Insl3 at doses >/=100 mg/kg and Star 
      expression at 200 mg/kg. Taking together, the present results indicated that 
      prenatal exposure of male rats to tetrabutyltin affected fetal Leydig cell 
      development.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Dong, Yaoyao
AU  - Dong Y
AD  - The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325027, China.
FAU - Zhao, Yu
AU  - Zhao Y
AD  - The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325027, China.
FAU - Zhu, Qiqi
AU  - Zhu Q
AD  - The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325027, China.
FAU - Wang, Zhe
AU  - Wang Z
AD  - The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325027, China.
FAU - Shan, Yuanyuan
AU  - Shan Y
AD  - The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325027, China.
FAU - Akingbemi, Benson T
AU  - Akingbemi BT
AD  - Department of Anatomy, Physiology and Pharmacology, Auburn University, Auburn AL 
      36849, USA.
FAU - Chen, Ruijie
AU  - Chen R
AD  - The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325027, China. Electronic address: 
      CRJ@wzhealth.com.
FAU - Zhu, Lihe
AU  - Zhu L
AD  - Department of Pathology, Wenzhou Hospital of Integrated Traditional and Western 
      Medicine, Wenzhou 325000, China. Electronic address: Zhulihe2013@163.com.
FAU - Ge, Ren-Shan
AU  - Ge RS
AD  - The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical 
      University, Wenzhou, Zhejiang 325027, China. Electronic address: r_ge@yahoo.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180405
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Insulin)
RN  - 0 (LHCGR protein, rat)
RN  - 0 (Leydig insulin-like protein)
RN  - 0 (Organotin Compounds)
RN  - 0 (Phosphoproteins)
RN  - 0 (Proteins)
RN  - 0 (Receptors, LH)
RN  - 0 (Scarb1 protein, rat)
RN  - 0 (Scavenger Receptors, Class B)
RN  - 0 (steroidogenic acute regulatory protein)
RN  - 1461-25-2 (tetrabutyltin)
RN  - 3XMK78S47O (Testosterone)
RN  - EC 1.14.14.19 (CYP17A1 protein, rat)
RN  - EC 1.14.14.19 (Steroid 17-alpha-Hydroxylase)
SB  - IM
MH  - Animals
MH  - Endocrine Disruptors/*toxicity
MH  - Female
MH  - Fetal Development/drug effects
MH  - Gene Expression Regulation, Developmental/drug effects
MH  - Insulin/genetics/metabolism
MH  - Male
MH  - *Maternal-Fetal Exchange
MH  - Organotin Compounds/*toxicity
MH  - Phosphoproteins/genetics
MH  - Pregnancy
MH  - Proteins/genetics/metabolism
MH  - Rats, Sprague-Dawley
MH  - Receptors, LH/genetics
MH  - Scavenger Receptors, Class B/genetics
MH  - Steroid 17-alpha-Hydroxylase/genetics
MH  - Testis/cytology/*drug effects/metabolism
MH  - Testosterone/metabolism
OTO - NOTNLM
OT  - Fetal Leydig cells
OT  - Leydig cell aggregation
OT  - Testosterone
OT  - Tetrabutyltin
EDAT- 2018/04/09 06:00
MHDA- 2018/11/06 06:00
CRDT- 2018/04/09 06:00
PHST- 2017/10/06 00:00 [received]
PHST- 2018/03/28 00:00 [revised]
PHST- 2018/04/03 00:00 [accepted]
PHST- 2018/04/09 06:00 [pubmed]
PHST- 2018/11/06 06:00 [medline]
PHST- 2018/04/09 06:00 [entrez]
AID - S0890-6238(17)30648-2 [pii]
AID - 10.1016/j.reprotox.2018.04.001 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2018 Jun;78:111-119. doi: 10.1016/j.reprotox.2018.04.001. Epub 
      2018 Apr 5.