PMID- 29627487
OWN - NLM
STAT- MEDLINE
DCOM- 20180928
LR  - 20181001
IS  - 1873-3492 (Electronic)
IS  - 0009-8981 (Linking)
VI  - 482
DP  - 2018 Jul
TI  - Meta-analysis of mitochondrial T16189C polymorphism for cancer and Type 2 
      diabetes risk.
PG  - 136-143
LID - S0009-8981(18)30157-8 [pii]
LID - 10.1016/j.cca.2018.03.041 [doi]
AB  - AIM: Whereas many previous studies have revealed that mitochondrial DNA (mtDNA) 
      polymorphism T16189C is associated with the risk of cancer and Type 2 diabetes 
      mellitus (T2DM), there are others that have disputed the same. As a result, 
      clarity on the role of mitochondrial T16189C in these disorders is missing. The 
      aim of this study is to evaluate the association of T16189C polymorphism with the 
      risk of cancer and T2DM development by pooling all case-control studies 
      available. METHODS: Published studies till November 2017 were searched from 
      PubMed, Google scholar, Google and EMBASE and isolated a total of 36 studies 
      having 44,203 subjects (20,439 cases and 23,764 controls) based on strict 
      inclusion and exclusion criteria. We used the statistical software "R" to 
      calculate the Pooled Odds Ratios and 95% confidence intervals to evaluate the 
      association of T16189C polymorphism with a possible risk towards cancer and T2DM 
      development. RESULT: From the meta-analysis, we obtained Pooled Odds Ratios using 
      Random effect model for cancer (OR: 1.20, 95% CI: 0.96-1.49, P = 0.104) and for 
      T2DM (OR: 1.22, 95% CI: 1.09-1.36, P = 0.0004). In the subgroup analysis with 
      Random effect model, we found that both Asians and Caucasians were at a 
      statistically significant risk (OR: 1.25, P < 0.0001 and OR: 1.20, P < 0.0001, 
      respectively) for the development of T2DM, whereas, a statistically 
      non-significant risk (OR: 1.28 P = 0.1965 and OR: 1.16, P = 0.1148) emerged for 
      the development of cancer. There was no evidence of a significant publication 
      bias (Egger's and Begg's test) in this meta-analysis. Further sensitivity 
      analysis also demonstrated that our meta-analysis was relatively stable and 
      credible. CONCLUSION: Individuals with 'C' allele at position 16,189 within the 
      mitochondrial D-loop are seemingly at a higher risk of developing T2DM and 
      cancer. However, before arriving at generalizations, it would be pertinent to 
      conduct similar studies in different populations with larger numbers to 
      corroborate these results, especially in cancer.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Kumari, Taruna
AU  - Kumari T
AD  - Department of Statistics, University of Delhi, New Delhi 110007, India.
FAU - Vachher, Meenakshi
AU  - Vachher M
AD  - Department of Biochemistry, Institute of Home Economics, University of Delhi, New 
      Delhi 110016, India.
FAU - Bansal, Savita
AU  - Bansal S
AD  - Department of Biochemistry, Institute of Home Economics, University of Delhi, New 
      Delhi 110016, India.
FAU - Bamezai, Rameshwar N K
AU  - Bamezai RNK
AD  - National Centre of Applied Human Genetics, School of Life Sciences, Jawaharlal 
      Nehru University, New Delhi 110067, India.
FAU - Kumar, Bhupender
AU  - Kumar B
AD  - Department of Biochemistry, Institute of Home Economics, University of Delhi, New 
      Delhi 110016, India. Electronic address: bhupender19@ihe.du.ac.in.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
DEP - 20180406
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (DNA, Mitochondrial)
SB  - IM
MH  - DNA, Mitochondrial/*genetics
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Neoplasms/*genetics
MH  - Odds Ratio
MH  - *Polymorphism, Single Nucleotide
OTO - NOTNLM
OT  - Cancer
OT  - Meta-analysis
OT  - T16189C
OT  - T2DM
OT  - mtDNA
EDAT- 2018/04/09 06:00
MHDA- 2018/10/03 06:00
CRDT- 2018/04/09 06:00
PHST- 2018/01/24 00:00 [received]
PHST- 2018/03/30 00:00 [revised]
PHST- 2018/03/30 00:00 [accepted]
PHST- 2018/04/09 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
PHST- 2018/04/09 06:00 [entrez]
AID - S0009-8981(18)30157-8 [pii]
AID - 10.1016/j.cca.2018.03.041 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2018 Jul;482:136-143. doi: 10.1016/j.cca.2018.03.041. Epub 2018 
      Apr 6.