PMID- 29627525
OWN - NLM
STAT- MEDLINE
DCOM- 20180604
LR  - 20180604
IS  - 1879-0038 (Electronic)
IS  - 0378-1119 (Linking)
VI  - 662
DP  - 2018 Jul 1
TI  - Adiponectin gene polymorphisms as a predictor for development of type 2 diabetes 
      mellitus in Iraqi population.
PG  - 118-122
LID - S0378-1119(18)30338-X [pii]
LID - 10.1016/j.gene.2018.03.087 [doi]
AB  - BACKGROUND: Type 2 diabetes mellitus (T2DM) incidence is increasing globally and 
      nationally. The etiology of the disease includes environmental and genetic 
      factors. Polymorphism of adiponectin gene was found to be implicated in the 
      pathogenesis of T2DM in numerous populations. METHODS: A case-control study was 
      conducted to assess the association of rs2241766 and rs822395 SNPs of adiponectin 
      gene (ADIPOQ) with T2DM in Iraqi population. The study included 400 patients with 
      T2DM and 400 healthy individuals served as a control group. Serum lipid 
      concentrations, insulin level and the index of insulin resistance (HOMA) were 
      measured. The genotyping of ADIPOQ for rs2241766 and rs822395 SNPs was performed 
      by PCR-RFLP. RESULTS: The genotype distribution of rs2241766 SNP indicated a 
      significant increase of carriers of the homozygous GG (OR: 5.04, CI95%: 
      2.27-11.19, P: 0.0001) and heterozygous TG (OR: 1.7, CI95%: 1.22-2.39, P: 0.002) 
      variants when compared with those of the wild type, suggesting a risk factor of 2 
      and 5 to develop the disease. The minor allele frequency (MAF) G was observed to 
      be significantly (P: 0.0001) higher in patients (22%) when compared with the 
      control group (11.74%). Results of rs822395 SNP failed to exhibit a significant 
      difference. Changes of BMI, cholesterol, triglycerides, insulin and insulin 
      resistance index values in the diabetic patients seemed to be parallel with the 
      presence of MAF of rs2241766 SNP. CONCLUSION: The rs2241766T>G SNP of adiponectin 
      gene is a risk factor for the development of T2DM in Iraqi population and directs 
      the changes of serum lipid concentrations as well as insulin resistance.
CI  - Copyright (c) 2018 Elsevier B.V. All rights reserved.
FAU - Hussain, Majid Kadhum
AU  - Hussain MK
AD  - Department of Biochemistry, College of Medicine, University of Kufa, Najaf, Iraq. 
      Electronic address: majid.alfatlawi@uokufa.edu.iq.
FAU - Deli, Falah Abdulhasan
AU  - Deli FA
AD  - Department of Internal Medicine, College of Medicine, University of Kufa, Najaf, 
      Iraq.
FAU - Algenabi, Abdul Hussein A
AU  - Algenabi AHA
AD  - Department of Biochemistry, College of Medicine, University of Kufa, Najaf, Iraq.
FAU - Abdul-Rudha, Khalid H
AU  - Abdul-Rudha KH
AD  - Department of Biochemistry, College of Medicine, University of Kufa, Najaf, Iraq.
LA  - eng
PT  - Journal Article
DEP - 20180405
PL  - Netherlands
TA  - Gene
JT  - Gene
JID - 7706761
RN  - 0 (ADIPOQ protein, human)
RN  - 0 (Adiponectin)
RN  - 0 (Insulin)
RN  - 0 (Triglycerides)
SB  - IM
MH  - Adiponectin/*genetics/metabolism
MH  - Adult
MH  - Aged
MH  - Alleles
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/blood/*genetics/metabolism
MH  - Female
MH  - Gene Frequency
MH  - Genetic Predisposition to Disease
MH  - Genetic Testing/methods
MH  - Genotype
MH  - Humans
MH  - Insulin/blood/genetics
MH  - Insulin Resistance/genetics
MH  - Iraq/epidemiology
MH  - Male
MH  - Middle Aged
MH  - Obesity/blood/genetics
MH  - Polymorphism, Single Nucleotide
MH  - Triglycerides/blood
OTO - NOTNLM
OT  - Adiponectin gene
OT  - Iraq
OT  - Polymorphism
OT  - rs2241766
OT  - rs822395
EDAT- 2018/04/09 06:00
MHDA- 2018/06/05 06:00
CRDT- 2018/04/09 06:00
PHST- 2017/10/15 00:00 [received]
PHST- 2018/03/23 00:00 [revised]
PHST- 2018/03/28 00:00 [accepted]
PHST- 2018/04/09 06:00 [pubmed]
PHST- 2018/06/05 06:00 [medline]
PHST- 2018/04/09 06:00 [entrez]
AID - S0378-1119(18)30338-X [pii]
AID - 10.1016/j.gene.2018.03.087 [doi]
PST - ppublish
SO  - Gene. 2018 Jul 1;662:118-122. doi: 10.1016/j.gene.2018.03.087. Epub 2018 Apr 5.