PMID- 29627721
OWN - NLM
STAT- MEDLINE
DCOM- 20181001
LR  - 20220331
IS  - 1876-2026 (Electronic)
IS  - 1876-2018 (Linking)
VI  - 34
DP  - 2018 Apr
TI  - Community-based comprehensive intervention for people with schizophrenia in 
      Guangzhou, China: Effects on clinical symptoms, social functioning, internalized 
      stigma and discrimination.
PG  - 21-30
LID - S1876-2018(17)30888-2 [pii]
LID - 10.1016/j.ajp.2018.04.017 [doi]
AB  - Comprehensive interventions including components of stigma and discrimination 
      reduction in schizophrenia in low- and middle-income countries (LMICs) are 
      lacking. We developed a community-based comprehensive intervention to evaluate 
      its effects on clinical symptoms, social functioning, internalized stigma and 
      discrimination among patients with schizophrenia. A randomized controlled trial 
      including an intervention group (n = 169) and a control group (n = 158) was 
      performed. The intervention group received comprehensive intervention (strategies 
      against stigma and discrimination, psycho-education, social skills training and 
      cognitive behavioral therapy) and the control group received face to face 
      interview. Both lasted for nine months. Participants were measured at baseline, 6 
      months and 9 months using the Internalized Stigma of Mental Illness scale (ISMI), 
      Discrimination and Stigma Scale (DISC-12), Global Assessment of Functioning 
      (GAF), Schizophrenia Quality of Life Scale (SQLS), Self-Esteem Scale (SES), Brief 
      Psychiatric Rating Scale (BPRS) and PANSS negative scale (PANSS-N). Insight and 
      medication compliance were evaluated by senior psychiatrists. Data were analyzed 
      by descriptive statistics, t-test, chi-square test or Fisher's exact test. Linear 
      Mixed Models were used to show intervention effectiveness on scales. General 
      Linear Mixed Models with multinomial logistic link function were used to assess 
      the effectiveness on medication compliance and insight. We found a significant 
      reduction on anticipated discrimination, BPRS and PANSS-N total scores, and an 
      elevation on overcoming stigma and GAF in the intervention group after 9 months. 
      These suggested the intervention may be effective in reducing anticipated 
      discrimination, increasing skills overcoming stigma as well as improving clinical 
      symptoms and social functioning in Chinese patients with schizophrenia.
CI  - Copyright (c) 2018 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Li, Jie
AU  - Li J
AD  - Guangzhou Huiai Hospital, Guangzhou Medical University, Guangzhou, China. 
      Electronic address: biglijie@163.com.
FAU - Huang, Yuan-Guang
AU  - Huang YG
AD  - Guangzhou Huiai Hospital, Guangzhou Medical University, Guangzhou, China. 
      Electronic address: yuan2011gz@163.com.
FAU - Ran, Mao-Sheng
AU  - Ran MS
AD  - Department of Social Work and Social Administration, The University of Hong Kong, 
      Hong Kong. Electronic address: msran@hku.hk.
FAU - Fan, Yu
AU  - Fan Y
AD  - Guangzhou Huiai Hospital, Guangzhou Medical University, Guangzhou, China. 
      Electronic address: exfanyu@163.com.
FAU - Chen, Wen
AU  - Chen W
AD  - Faculty of Medical Statistics and Epidemiology, School of Public Health, Sun 
      Yat-sen University, Sun Yat-sen Center for Migrant Health Policy, Guangzhou, 
      China. Electronic address: chenw43@mail.sysu.edu.cn.
FAU - Evans-Lacko, Sara
AU  - Evans-Lacko S
AD  - Personal Social Services Research Unit, London School of Economics and Political 
      Science, Centre for Global Mental Health, Institute of Psychiatry, Psychology and 
      Neuroscience, King's College London, London, UK. Electronic address: 
      sara.evans-lacko@kcl.ac.uk.
FAU - Thornicroft, Graham
AU  - Thornicroft G
AD  - Centre for Global Mental Health, Institute of Psychiatry, Psychology and 
      Neuroscience, King's College London, London SE5 8AF, UK. Electronic address: 
      graham.thornicroft@kcl.ac.uk.
LA  - eng
GR  - MR/R023697/1/MRC_/Medical Research Council/United Kingdom
GR  - MR/S001255/1/MRC_/Medical Research Council/United Kingdom
GR  - RP-PG-0606-1053/DH_/Department of Health/United Kingdom
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20180403
PL  - Netherlands
TA  - Asian J Psychiatr
JT  - Asian journal of psychiatry
JID - 101517820
SB  - IM
MH  - Adult
MH  - China
MH  - Community Mental Health Services/*methods
MH  - Developing Countries
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Outcome Assessment, Health Care
MH  - Prejudice/ethnology/*prevention & control
MH  - Psychotherapy/*methods
MH  - Schizophrenia/physiopathology/*therapy
MH  - *Self Concept
MH  - *Social Stigma
OTO - NOTNLM
OT  - Community
OT  - Low-and middle-income countries
OT  - Psychosocial interventions
OT  - Schizophrenia
OT  - Stigma and discrimination
EDAT- 2018/04/09 06:00
MHDA- 2018/10/03 06:00
CRDT- 2018/04/09 06:00
PHST- 2017/12/14 00:00 [received]
PHST- 2018/02/24 00:00 [revised]
PHST- 2018/04/01 00:00 [accepted]
PHST- 2018/04/09 06:00 [pubmed]
PHST- 2018/10/03 06:00 [medline]
PHST- 2018/04/09 06:00 [entrez]
AID - S1876-2018(17)30888-2 [pii]
AID - 10.1016/j.ajp.2018.04.017 [doi]
PST - ppublish
SO  - Asian J Psychiatr. 2018 Apr;34:21-30. doi: 10.1016/j.ajp.2018.04.017. Epub 2018 
      Apr 3.