PMID- 29627737
OWN - NLM
STAT- MEDLINE
DCOM- 20190726
LR  - 20220408
IS  - 1878-0180 (Electronic)
IS  - 1878-0180 (Linking)
VI  - 82
DP  - 2018 Jun
TI  - In-vitro biocompatibility, bioactivity, and mechanical strength of PMMA-PCL 
      polymer containing fluorapatite and graphene oxide bone cements.
PG  - 257-267
LID - S1751-6161(18)30308-4 [pii]
LID - 10.1016/j.jmbbm.2018.03.016 [doi]
AB  - In this study, a bone cement consisting of poly methyl methacrylate (PMMA)-poly 
      caprolactone (PCL)-fluorapatite (FA)-graphene oxide (GO) was synthesized as bone 
      filler for application in orthopedic surgeries. The FA and GO particulates were 
      homogenously distributed in the PMMA-PCL polymer matrix and no defects and 
      agglomeration were found in the PMMA-PCL/FA/GO bone cement. The in-vitro 
      bioactivity result exhibited that addition of FA and GO to the polymer cement 
      (PMMA-PCL) improved the apatite formation ability on the surface of polymer. The 
      results also showed that addition of FA to the polymer bone cement escalated the 
      compressive strength and elastic modulus while reducing elongation to 8 +/- 2%. 
      However, after addition of GO into the PMMA-PCL/FA bone cement, both compressive 
      strength and elongation considerably increased to 101 +/- 5 MPa and 35 +/- 6%, 
      respectively. Furthermore, tensile tests exhibited that inclusion of GO was 
      favorable in improving the tensile modulus, UTS and elongation of the PMMA-PCL/FA 
      bone cement. The cytotoxicity test pointed out that MG63 osteoblast cells 
      viability increased to 279 +/- 15% after addition of FA and GO to the PMMA-PCL 
      polymer bone cement. The DAPI (4',6-diamidino-2-phenylindole) staining 
      demonstrated better spreading and attachment of MG63 cells on PMMA-PCL/FA/GO 
      surface compared to the PMMA-PCL bone cements. These results confirm the suitable 
      mechanical properties and favorable bioactivity along with high cells viability 
      of PMMA-PCL/FA/GO bone cement, indicating its potentials for orthopedic 
      applications.
CI  - Copyright (c) 2018 Elsevier Ltd. All rights reserved.
FAU - Pahlevanzadeh, F
AU  - Pahlevanzadeh F
AD  - Department of Tissue Engineering, Najafabad branch, Islamic Azad University, 
      Najafabad, Iran.
FAU - Bakhsheshi-Rad, H R
AU  - Bakhsheshi-Rad HR
AD  - Advanced Materials Research Center, Department of Materials Engineering, 
      Najafabad Branch, Islamic Azad University, Najafabad, Iran. Electronic address: 
      rezabakhsheshi@pmt.iaun.ac.ir.
FAU - Hamzah, E
AU  - Hamzah E
AD  - Department of Materials, Manufacturing and Industrial Engineering, Faculty of 
      Mechanical Engineering, Universiti Teknologi Malaysia, 81310 Skudai, Johor Bahru, 
      Johor, Malaysia.
LA  - eng
PT  - Journal Article
DEP - 20180315
PL  - Netherlands
TA  - J Mech Behav Biomed Mater
JT  - Journal of the mechanical behavior of biomedical materials
JID - 101322406
RN  - 0 (Apatites)
RN  - 0 (Bone Cements)
RN  - 0 (Oxides)
RN  - 0 (Polyesters)
RN  - 24980-41-4 (polycaprolactone)
RN  - 7782-42-5 (Graphite)
RN  - 9011-14-7 (Polymethyl Methacrylate)
RN  - M4CM1H238J (fluorapatite)
MH  - Apatites/*chemistry
MH  - Bone Cements/*chemistry/pharmacology
MH  - Cell Line
MH  - Cell Proliferation/drug effects
MH  - Cell Survival/drug effects
MH  - Graphite/*chemistry
MH  - Humans
MH  - Materials Testing
MH  - *Mechanical Phenomena
MH  - Models, Molecular
MH  - Molecular Conformation
MH  - Osteoblasts/cytology/drug effects
MH  - Oxides/*chemistry
MH  - Polyesters/*chemistry
MH  - Polymethyl Methacrylate/*chemistry
OTO - NOTNLM
OT  - Bioactivity
OT  - Biocompatibility
OT  - Mechanical properties
OT  - Polymer bone cement
EDAT- 2018/04/09 06:00
MHDA- 2019/07/28 06:00
CRDT- 2018/04/09 06:00
PHST- 2017/12/29 00:00 [received]
PHST- 2018/03/08 00:00 [revised]
PHST- 2018/03/12 00:00 [accepted]
PHST- 2018/04/09 06:00 [pubmed]
PHST- 2019/07/28 06:00 [medline]
PHST- 2018/04/09 06:00 [entrez]
AID - S1751-6161(18)30308-4 [pii]
AID - 10.1016/j.jmbbm.2018.03.016 [doi]
PST - ppublish
SO  - J Mech Behav Biomed Mater. 2018 Jun;82:257-267. doi: 10.1016/j.jmbbm.2018.03.016. 
      Epub 2018 Mar 15.