PMID- 29628598
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20200929
IS  - 0259-1162 (Print)
IS  - 2229-7685 (Electronic)
IS  - 2229-7685 (Linking)
VI  - 12
IP  - 1
DP  - 2018 Jan-Mar
TI  - Transient Receptor Potential Channels as Blood Biomarkers for Pain 
      Characteristics in Patients with Chronic Pain.
PG  - 279-281
LID - 10.4103/aer.AER_179_17 [doi]
AB  - Transient receptor potential (TRP) channels play key roles for the transition 
      from acute to chronic postoperative pain after surgery. To evaluate TRP channels 
      in the peripheral blood cells as blood biomarkers for chronic pain, we collected 
      blood samples for genome-wide assays of the mRNA expression and assessed pain 
      intensity and the number of pain symptoms in 13 patients with chronic pain. There 
      was a significant association between increases in the number of pain symptoms 
      and increases in the TRP vanilloid 1 (TRPV1) expression. Decreases in the TRP 
      ankyrin 1 (TRPA1) expression, however, tended to increase the number of pain 
      symptoms. There was likely an inverse relationship for TRPV1 and TRPA1 
      expressions with regard to the number of pain symptoms in chronic pain patients.
FAU - Sukenaga, Norihiko
AU  - Sukenaga N
AD  - Department of Anesthesiology and Pain Medicine, Hyogo College of Medicine, Hyogo, 
      Japan.
FAU - Hirose, Munetaka
AU  - Hirose M
AD  - Department of Anesthesiology and Pain Medicine, Hyogo College of Medicine, Hyogo, 
      Japan.
LA  - eng
PT  - Case Reports
PL  - India
TA  - Anesth Essays Res
JT  - Anesthesia, essays and researches
JID - 101578762
PMC - PMC5872882
OTO - NOTNLM
OT  - Biomarker
OT  - chronic pain
OT  - transient receptor potential ankyrin 1
OT  - transient receptor potential vanilloid 1
COIS- There are no conflicts of interest.
EDAT- 2018/04/10 06:00
MHDA- 2018/04/10 06:01
PMCR- 2018/01/01
CRDT- 2018/04/10 06:00
PHST- 2018/04/10 06:00 [entrez]
PHST- 2018/04/10 06:00 [pubmed]
PHST- 2018/04/10 06:01 [medline]
PHST- 2018/01/01 00:00 [pmc-release]
AID - AER-12-279 [pii]
AID - 10.4103/aer.AER_179_17 [doi]
PST - ppublish
SO  - Anesth Essays Res. 2018 Jan-Mar;12(1):279-281. doi: 10.4103/aer.AER_179_17.