PMID- 29629278
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220408
IS  - 2211-9132 (Print)
IS  - 2211-9140 (Electronic)
IS  - 2211-9132 (Linking)
VI  - 37
IP  - 1
DP  - 2018 Mar
TI  - Association of proton pump inhibitor use with renal outcomes in patients with 
      coronary artery disease.
PG  - 59-68
LID - 10.23876/j.krcp.2018.37.1.59 [doi]
AB  - BACKGROUND: Several studies have suggested that proton pump inhibitor (PPI) use 
      is associated with adverse renal outcomes, but obvious evidence for this 
      association is lacking. We investigated the association between PPI use and 
      adverse renal outcomes in patients who had undergone percutaneous coronary 
      intervention. METHODS: Of the 1,284 patients hospitalized for percutaneous 
      coronary intervention between January 2007 and May 2012, 934 patients with 
      baseline estimated glomerular filtration rate greater than 60 mL/min/1.73 m(2) 
      were enrolled. Multivariable Cox models were used to examine whether PPI use was 
      associated with acute and chronic adverse renal outcomes. RESULTS: In adjusted 
      time-dependent Cox models, PPI use was associated with acute kidney injury 
      (hazard ratio [HR], 1.46; 95% confidence interval [95% CI], 1.05-2.02), 
      especially in patients aged 65 years or younger (HR, 2.08; 95% CI, 1.09 3.96) or 
      in patients with diabetes (HR, 2.00; 95% CI, 1.23-3.25). In multivariable Cox 
      models, the association between duration of PPI use and chronic kidney disease 
      development was not statistically significant (HR of heavy users, 1.50; 95% CI, 
      0.61-3.67), but a longer duration of PPI use was associated with mild renal 
      progression in patients younger than 65 years (HR of heavy users, 2.24; 95% CI, 
      1.09-4.60). CONCLUSION: Our results suggest that PPI use increases the risk of 
      AKI development, and that PPI use is more significantly associated with acute and 
      chronic renal injuries in younger patients.
FAU - Cho, Nam-Jun
AU  - Cho NJ
AD  - Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, 
      Cheonan, Korea.
FAU - Choi, Chi-Young
AU  - Choi CY
AD  - Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, 
      Cheonan, Korea.
FAU - Park, Samel
AU  - Park S
AD  - Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, 
      Cheonan, Korea.
FAU - Park, Sang-Ho
AU  - Park SH
AD  - Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, 
      Cheonan, Korea.
FAU - Lee, Eun Young
AU  - Lee EY
AD  - Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, 
      Cheonan, Korea.
FAU - Gil, Hyo-Wook
AU  - Gil HW
AD  - Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, 
      Cheonan, Korea.
LA  - eng
PT  - Journal Article
DEP - 20180331
PL  - Korea (South)
TA  - Kidney Res Clin Pract
JT  - Kidney research and clinical practice
JID - 101586778
PMC - PMC5875577
OTO - NOTNLM
OT  - Acute kidney injury
OT  - Chronic kidney failure
OT  - Proton pump inhibitors
OT  - Risk factors
COIS- Conflicts of interest All authors have no conflicts of interest to declare.
EDAT- 2018/04/10 06:00
MHDA- 2018/04/10 06:01
PMCR- 2018/03/01
CRDT- 2018/04/10 06:00
PHST- 2017/10/17 00:00 [received]
PHST- 2018/01/31 00:00 [revised]
PHST- 2018/02/10 00:00 [accepted]
PHST- 2018/04/10 06:00 [entrez]
PHST- 2018/04/10 06:00 [pubmed]
PHST- 2018/04/10 06:01 [medline]
PHST- 2018/03/01 00:00 [pmc-release]
AID - krcp-37-059 [pii]
AID - 10.23876/j.krcp.2018.37.1.59 [doi]
PST - ppublish
SO  - Kidney Res Clin Pract. 2018 Mar;37(1):59-68. doi: 10.23876/j.krcp.2018.37.1.59. 
      Epub 2018 Mar 31.