PMID- 29630749
OWN - NLM
STAT- MEDLINE
DCOM- 20180503
LR  - 20190221
IS  - 1600-0463 (Electronic)
IS  - 0903-4641 (Linking)
VI  - 126
IP  - 5
DP  - 2018 May
TI  - The association between immunoexpression levels of oxidant and antioxidant 
      enzymes and lip squamous cell carcinoma.
PG  - 403-412
LID - 10.1111/apm.12824 [doi]
AB  - The aim of this study was to investigate the associations among the 
      immunoexpression levels of manganese superoxide dismutase (Mn-SOD), glutathione 
      peroxidase (GPx), and myeloperoxidase (MPO) in lip squamous cell carcinoma (LSCC) 
      tissues and the clinicopathological characteristics, and prognostic factors in 
      patients with LSCC. The immunoexpression levels of Mn-SOD, GPx, and MPO were 
      examined in 76 LSCC tissue samples using immunohistochemical staining on tissue 
      microarray slides, and compared to those in normal lip mucosa adjacent to venous 
      lakes (normal controls), normal tissue adjacent to corresponding tumors (NTACT), 
      and recurrent tumors. Associations between immunoexpression levels and 
      clinicopathological characteristics were analyzed using the Student's t-test. The 
      prognostic factors were analyzed using Cox regression. The immunoexpression 
      levels of Mn-SOD, GPx, and MPO were significantly different among the normal 
      controls, NTACTs, tumors, and recurrent tumors (Mn-SOD: p = 0.001, GPx: 
      p < 0.001, MPO: p < 0.001). Lower lip cancer was associated with higher Mn-SOD 
      immunoexpression levels (p = 0.04) and probably indicated higher oxidative 
      stress. Lymph node involvement with a lower immunoexpression level of MPO 
      (p = 0.007) indicated compensatory mechanism to attenuate oxidative damage. A low 
      Mn-SOD immunoexpression level was borderline significantly associated with a 
      worse prognosis for disease-specific survival, and it was probably related to a 
      lower capacity for coping with oxidative stress.
CI  - (c) 2018 APMIS. Published by John Wiley & Sons Ltd.
FAU - Tseng, Hui-Wen
AU  - Tseng HW
AD  - Department of Dermatology, Kaohsiung Veterans General Hospital, Kaohsiung, 
      Taiwan.
AD  - Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, 
      Taiwan.
FAU - Tseng, Hui-Hwa
AU  - Tseng HH
AD  - Department of Anatomic Pathology, Taipei Tzu Chi hospital, New Taipei City, 
      Taiwan.
FAU - Liou, Huei-Han
AU  - Liou HH
AD  - Department of Medical Education and Research, Kaohsiung Veterans General 
      Hospital, Kaohsiung, Taiwan.
FAU - Tsai, Kuo-Wang
AU  - Tsai KW
AD  - Department of Medical Education and Research, Kaohsiung Veterans General 
      Hospital, Kaohsiung, Taiwan.
FAU - Ger, Luo-Ping
AU  - Ger LP
AD  - Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, 
      Taiwan.
AD  - Department of Medical Education and Research, Kaohsiung Veterans General 
      Hospital, Kaohsiung, Taiwan.
FAU - Shiue, Yow-Ling
AU  - Shiue YL
AD  - Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, 
      Taiwan.
LA  - eng
PT  - Journal Article
DEP - 20180406
PL  - Denmark
TA  - APMIS
JT  - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
JID - 8803400
RN  - EC 1.11.1.7 (Peroxidase)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Squamous Cell/*enzymology/mortality/pathology
MH  - Female
MH  - Glutathione Peroxidase/*analysis
MH  - Head and Neck Neoplasms/*enzymology/mortality/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Lip Neoplasms/*enzymology/mortality/pathology
MH  - Male
MH  - Middle Aged
MH  - Peroxidase/analysis
MH  - Squamous Cell Carcinoma of Head and Neck
MH  - Superoxide Dismutase/*analysis
OTO - NOTNLM
OT  - Lip squamous cell carcinoma
OT  - glutathione peroxidase
OT  - immunoexpression level
OT  - manganese superoxide dismutase
OT  - myeloperoxidase
EDAT- 2018/04/10 06:00
MHDA- 2018/05/04 06:00
CRDT- 2018/04/10 06:00
PHST- 2017/08/02 00:00 [received]
PHST- 2018/01/26 00:00 [accepted]
PHST- 2018/04/10 06:00 [pubmed]
PHST- 2018/05/04 06:00 [medline]
PHST- 2018/04/10 06:00 [entrez]
AID - 10.1111/apm.12824 [doi]
PST - ppublish
SO  - APMIS. 2018 May;126(5):403-412. doi: 10.1111/apm.12824. Epub 2018 Apr 6.