PMID- 29630924
OWN - NLM
STAT- MEDLINE
DCOM- 20190503
LR  - 20190503
IS  - 1873-6815 (Electronic)
IS  - 0531-5565 (Linking)
VI  - 108
DP  - 2018 Jul 15
TI  - Reaction time in healthy elderly is associated with chronic low-grade 
      inflammation and advanced glycation end product.
PG  - 118-124
LID - S0531-5565(18)30035-4 [pii]
LID - 10.1016/j.exger.2018.04.002 [doi]
AB  - Chronic inflammation and Advanced Glycation End products (AGE) are associated 
      with sarcopenia. Decreased voluntary muscle activation and increased antagonist 
      coactivation can contribute to age-related muscle weakness. The influence of 
      chronic inflammation and AGE in these neuromuscular mechanisms is not clear. We 
      studied whether a relation exists between circulating levels of inflammatory 
      cytokines and AGEs as well as the interplay between agonist and antagonist muscle 
      activation. We studied 64 community-dwelling old subjects, during a maximal 
      isometric voluntary contraction (MVC) and a reaction-time (RT) test of the upper 
      limb. Twenty-five circulating inflammatory biomarkers were determined. Linear 
      regression showed significant relationships between chronic inflammation and six 
      muscle activation parameters. MIP-1beta showed a significant negative relation with 
      antagonist coactivation (during MVC) and antagonist muscle activity during 
      pre-movement time (PMT) and movement time (MT) (during RT). A higher level of 
      pentosidine (AGE) was predictive for a longer PMT. We conclude that in older 
      relatively healthy persons antagonist muscle activation is influenced by chronic 
      inflammation, contributing to age-related muscle weakness. Our results also 
      suggest a mechanical and inflammatory influence of pentosidine in upper limb 
      slowing of movement. These findings show novel insight in underlying mechanisms 
      of age-related muscle weakness.
CI  - Copyright (c) 2018 Elsevier Inc. All rights reserved.
FAU - Arnold, Pauline
AU  - Arnold P
AD  - Geriatric Physiotherapy Department, SOMT University of Physiotherapy, Amersfoort, 
      The Netherlands; Frailty in Ageing Research Department, Vrije Universiteit 
      Brussel (VUB), Brussels, Belgium.
FAU - Njemini, Rose
AU  - Njemini R
AD  - Gerontology Department Vrije Universiteit Brussel (VUB), Brussels, Belgium; 
      Frailty in Ageing Research Department, Vrije Universiteit Brussel (VUB), 
      Brussels, Belgium.
FAU - Vantieghem, Stijn
AU  - Vantieghem S
AD  - Frailty in Ageing Research Department, Vrije Universiteit Brussel (VUB), 
      Brussels, Belgium.
FAU - Gorus, Ellen
AU  - Gorus E
AD  - Gerontology Department Vrije Universiteit Brussel (VUB), Brussels, Belgium; 
      Frailty in Ageing Research Department, Vrije Universiteit Brussel (VUB), 
      Brussels, Belgium; Geriatrics Department, Universitair Ziekenhuis Brussel, 
      Brussels, Belgium.
FAU - Pool-Goudzwaard, Annelies
AU  - Pool-Goudzwaard A
AD  - Geriatric Physiotherapy Department, SOMT University of Physiotherapy, Amersfoort, 
      The Netherlands; Men & Women's Health care department, Somt University of 
      Physiotherapy, Amersfoort, The Netherlands; Amsterdam Movement Sciences, 
      Department of Human Movement Sciences, VU, Amsterdam, The Netherlands.
FAU - Buyl, Ronald
AU  - Buyl R
AD  - Geriatric Physiotherapy Department, SOMT University of Physiotherapy, Amersfoort, 
      The Netherlands; Biostatistics and Medical Informatics Department, Faculty of 
      Medicine, Vrije Universiteit Brussel (VUB), Brussels, Belgium.
FAU - Bautmans, Ivan
AU  - Bautmans I
AD  - Geriatric Physiotherapy Department, SOMT University of Physiotherapy, Amersfoort, 
      The Netherlands; Gerontology Department Vrije Universiteit Brussel (VUB), 
      Brussels, Belgium; Frailty in Ageing Research Department, Vrije Universiteit 
      Brussel (VUB), Brussels, Belgium; Geriatrics Department, Universitair Ziekenhuis 
      Brussel, Brussels, Belgium. Electronic address: ivan.bautmans@vub.be.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20180406
PL  - England
TA  - Exp Gerontol
JT  - Experimental gerontology
JID - 0047061
RN  - 0 (Biomarkers)
RN  - 0 (Glycation End Products, Advanced)
RN  - 94ZLA3W45F (Arginine)
RN  - BJ4I2X2CQJ (pentosidine)
RN  - K3Z4F929H6 (Lysine)
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aging/*metabolism
MH  - Arginine/*analogs & derivatives/metabolism
MH  - Biomarkers/metabolism
MH  - Electromyography
MH  - Female
MH  - Glycation End Products, Advanced/*metabolism
MH  - Humans
MH  - Inflammation/*metabolism
MH  - Isometric Contraction
MH  - Linear Models
MH  - Lysine/*analogs & derivatives/metabolism
MH  - Male
MH  - Muscle Weakness/etiology
MH  - Muscle, Skeletal/metabolism
MH  - *Reaction Time
MH  - Sarcopenia/etiology
MH  - Sex Factors
OTO - NOTNLM
OT  - Advanced glycation end product
OT  - Aging
OT  - Antagonist coactivation
OT  - Chronic inflammation
OT  - Cytokines
EDAT- 2018/04/10 06:00
MHDA- 2019/05/06 06:00
CRDT- 2018/04/10 06:00
PHST- 2018/01/17 00:00 [received]
PHST- 2018/02/21 00:00 [revised]
PHST- 2018/04/02 00:00 [accepted]
PHST- 2018/04/10 06:00 [pubmed]
PHST- 2019/05/06 06:00 [medline]
PHST- 2018/04/10 06:00 [entrez]
AID - S0531-5565(18)30035-4 [pii]
AID - 10.1016/j.exger.2018.04.002 [doi]
PST - ppublish
SO  - Exp Gerontol. 2018 Jul 15;108:118-124. doi: 10.1016/j.exger.2018.04.002. Epub 
      2018 Apr 6.